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Approaches to solving gadolinium-based interference in selenium measurement

Selenium (Se) is an essential trace element in many biological processes. Se is measured in many sample matrices. The gold standard Se measurement method is inductively coupled plasma mass spectrometry (ICP-MS). Monitoring alternative isotopes, applying correction factors, and utilizing ICP with a triple quadrupole mass spectrometer are approaches to mitigate the interference of doubly-charged gadolinium.