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21

Biomarkers for improved management of prostate cancer

Prostate cancer is an extremely complex and heterogenous disease. A significant problem in the clinical management of PCa is being able to accurately stratify patients based on their risk for aggressive disease. Traditional biomarkers and clinical methods for personalized treatment are insufficient. Appropriate stratification of patients based on their risk for aggressive disease is required […]

22

Why we should be measuring ionized magnesium

The majority of magnesium in the body is located in bone and muscle; however, the small extracellular proportion of ionized magnesium plays an important role in a number of physiologic processes. Generally, when assessing magnesium concentration, total magnesium is measured. This article discusses the importance of ionized magnesium and why we should be directly measuring […]

23

Tracing footsteps: exploring friendly viruses to diagnose Lyme disease

Despite the progress that has been achieved in Lyme disease (LD) diagnostic development in recent years, lack of early and effective diagnosis of LD remains a major cause of misdiagnosis and long-term patient suffering. We invented a novel way of detecting LD-causing bacteria. The new technology could potentially transform LD diagnostics through the innovative use […]

24

Role of external quality assessment in clinical laboratory quality assurance

When specimens are analysed in the clinical laboratory, it is crucial that the results that are reported back to the clinician are accurate. If not, at best, results would not be comparable from the same laboratory on different days or between different laboratories at all. At worst, disease could remain undiagnosed or over-diagnosed with the […]

29

A microscopic look at aneurysm repair

Hitting a pothole on the road in just the wrong way might create a bulge on the tire, a weakened spot that will almost certainly lead to an eventual flat tire. But what if that tire could immediately begin reknitting its rubber, reinforcing the bulge and preventing it from bursting?

30

New immunotherapy target discovered for malignant brain tumour

Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumours, which so far have resisted the ground-breaking cancer treatment based on harnessing the body’s immune system. The discovery, reported in the journal CELL, emerged from laboratory experiments and has no immediate implications for treating patients.