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33

Capricorn Scientific and ExcellGene form strategic partnership to support biotech industries

Capricorn Scientific and ExcellGene have established a strategic partnership within the biotechnology sector. Applying their collective expertise and capabilities, the collaboration seeks to help customers by optimizing processes, developing products, and offering solutions in biotechnology. The partnership is dedicated to customeroriented solutions and a commitment to excellence, with the aim of advancing biotech research, development, […]

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PharmaKure announces epigenetics collaboration with Sheffield Hallam University to understand mechanisms of Alzheimer’s Disease

PharmaKure, a clinical stage pharmaceutical company developing precision medicines for Alzheimer’s Disease (AD) and other neurodegenerative diseases, will collaborate with Sheffield Hallam University in the field of epigenetics. The partnership will focus on ‘gene-based environmental biomarkers’ – epigenetic markers – for calculating risk scores for Alzheimer’s diseases. Together with PharmaKure’s blood-based biomarker, ALZmetrix https://bitly.ws/3eZTQ, this […]

35

Johnson & Johnson to acquire Ambrx to advance nextgen antibody drug conjugates for cancer treatment

Johnson & Johnson has entered into a definitive agreement to acquire Ambrx Biopharma, a clinical-stage biopharmaceutical company with a proprietary synthetic biology technology platform to design and develop next-generation antibody drug conjugates (ADCs), in an all-cash merger transaction for a total equity value of approximately $2 billion, or $1.9 billion net of estimated cash acquired.

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Biomarkers in heart failure | Beyond laboratory values

by Dr Roopa Rao and Arden Shen The incidence of heart failure (HF) is increasing globally. Biomarkers in HF play a key role in diagnosis and prognostication. Ideal biomarkers should be easily measurable with distinct values in normal physiology, disease state and be a marker of therapeutic intervention. Several biomarkers have emerged that are potentially […]

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Rapid detection of periprosthetic joint infections

By Dr Kyle H. Cichos and Dr Wilhelm Paulander This review examines periprosthetic joint infection (PJI) detection, highlighting the limitations of traditional methods and introducing isothermal microcalorimetry (IMC) as an innovative tool. IMC offers rapid, sensitive PJI detection, overcoming the challenges of culture-based and molecular diagnostics. Its potential applications in real-time monitoring, treatment efficacy, and […]

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Detection of cardiolipins using liquid chromatography-tandem mass spectrometry for diagnosis of Barth syndrome

By Dr Seul Kee Byeon and Dr Akhilesh Pandey An elevated ratio of monolysocardiolipin to cardiolipin is a hallmark feature of Barth syndrome, a genetic disorder caused by mutations in the TAFAZZIN gene. Liquid chromatography-tandem mass spectrometry can be used as a clinical laboratory test to calculate the ratios of monolysocardiolipins to cardiolipin species for […]

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Development of a urine test for endometriosis

Endometriosis is an incurable, chronic condition, associated with debilitating pain and reduced fertility. It is thought to affect 190 million women worldwide and is associated with huge costs to the economy though loss of earnings and cost of health-care/treatment. Currently, diagnosis on average takes around 8 years. CLI chatted to Dr Barbara Guinn (Centre for […]