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New mechanism for dysfunctional insulin release identified

In a new study, researchers at Uppsala University have identified a previously unknown mechanism that regulates release of insulin, a hormone that lowers blood glucose levels, from the β-cells (beta cells) of the pancreas. This mechanism is disrupted in type 2 diabetes. The scientists hope this finding will be used to develop new treatments against […]


Acute pancreatitis biomarkers: to many or too few?

by Dr Allison B. Chambliss The diagnosis of acute pancreatitis has long relied on elevations in serum amylase or lipase. Recent test utilization efforts have called f or the discontinuation of amylase in acute pancreatitis, favouring the higher specificity and longer elevation of lipase. However, neither biomarker correlates with disease severity, and early recognition of […]


Protein misfolding as a risk marker for Alzheimer’s disease

In symptom-free individuals, the detection of misfolded amyloid-β protein in the blood indicated a considerably higher risk of Alzheimer’s disease – up to 14 years before a clinical diagnosis was made. Amyloid-β folding proved to be superior to other risk markers evaluated, as shown by scientists from the German Cancer Research Center (DKFZ), Ruhr University […]


Introducing new tests to a laboratory’s repertoire

Expert opinions from Dr Heidi Mendoza There are many assessments to make when adding a new test to a lab’s collection. Dr Heidi Mendoza, acting consultant clinical biochemist at Raigmore Hospital, Inverness, UK, shares her experiences and observations of doing exactly that in both ordinary circumstances and during a pandemic, as well as having to […]


Cobra Biologics and the Karolinska Institutet collaborate to develop COVID-19 vaccine

Cobra Biologics (Cobra), an international contract development and manufacturing organization (CDMO) for biologics and pharmaceuticals, and the Karolinska Institutet (KI), one of the world’s leading medical universities, announced 30 March they have been awarded €3 million emergency funding by Horizon 2020 for research and development, and phase I clinical trial testing of a DNA vaccine […]


Horiba Yumizen hematology analysers minimize microscopy slide reviews

Horiba has recently announced the publication of scientific studies which demonstrate the excellent performance of its new HELO high throughput fully automated hematology platform on body fluid and pathological samples. Horiba’s Yumizen® H2500 and H1500 automated hematology analysers within the HELO platform deliver enhanced precision for complete blood counts and white blood cell (WBC) differential […]


Avacta ships SARS-COV-2 Affimer reagents to Cytiva and Adeptrix for diagnostic test development

Avacta Group plc, the developer of Affimer biotherapeutics and reagents, has started shipping Affimer reagents for COVID-19 antigen testing to its diagnostic test development partners. The Group recently reported that it had generated multiple, highly specific Affimer reagents that bind the SARS-COV-2 viral antigen and do not cross-react with SARS, MERS and other closely related […]


Siemens Healthineers awarded FDA approval for RAPIDPoint 500e Blood Gas Analyzer

Siemens Healthineers’s latest critical care testing solution, the RAPIDPoint® 500e Blood Gas Analyzer, has received clearance from the U.S. FDA, and is now available in the U.S., Europe and countries requiring the CE mark. The analyser generates blood gas, electrolyte, metabolite, CO-oximetry, and neonatal bilirubin results, which are used to diagnose and monitor critically ill […]