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1741

Siemens starts worldwide shipping of total antibody test for COVID-19

Siemens Healthineers announced late May that it is now shipping worldwide its laboratory-based total antibody test to detect the presence of SARS-CoV-2 IgM and IgG antibodies in blood. The test received the CE mark and data has demonstrated 100 percent sensitivity and 99.8 percent specificity. The total antibody test allows for identification of patients who […]

1742

UK consortium set to trial COVID-19 adenoviral vaccine candidate

A research consortium led by the Jenner Institute, Oxford University is set to begin fast-tracked clinical trials for a COVID-19 vaccine. The adenoviral vaccine candidate, ChAdOx1 nCov-19 (ChAdOx1) is one of five frontrunner vaccines in development around the world, and expected to be the UK’s first COVID-19 vaccine. Developed at the Jenner Institute, ChAdOx1 is […]

1744

Parallel genetic testing for primary lactose intolerance and hereditary fructose intolerance

by Dr Jacqueline Gosink Gastrointestinal complaints are very common and can be difficult to diagnose. Among the many causes are genetic deficiencies in digestive enzymes. Molecular genetic analysis of polymorphisms in the patient’s DNA can determine if inborn enzyme deficits are behind the digestive problems, aiding differential diagnostics. Primary lactose intolerance, for example, is associated […]

1745

New findings could improve diagnosis, treatment of depression

Researchers at the University of California, Berkeley, have identified biomarkers – genes and specific brain circuits in mice – associated with a common symptom of depression: lack of motivation. The finding could guide research to find new ways to diagnose and potentially treat individuals suffering from lack of motivation and bring closer the day of […]

1746

Immune cells key to predicting cancer outcomes

Scientists have identified key changes in immune cells within cancerous tumours that could help improve the development of treatments. The study also found a set of genes that are expressed at high levels in breast cancer tumours and linked to more aggressive cancer types. Researchers say the discoveries offer clues to diagnosis and predicting patient […]

1747

Erythrocyte sedimentation rate: getting the most out of this test

by Peter Murphy It was first noticed that the rate of erythrocyte sedimentation changed owing to illness in the 1700s. The use of this attribute as a measure of inflammatory activity due to underlying disease was formalized into a test in the early 1900s and what has become known as the Westergren test has again […]

1748

Beckman Coulter to produce antibody assays for Covid-19

In response to the global COVID-19 pandemic, Beckman Coulter, a global leader in clinical diagnostics, announced 31 March that it is developing assays to identify IgM and IgG antibodies to SARS-CoV-2. Research has shown that after infection with SARS-CoV-2, viral antigens stimulate the body’s immune system to produce antibodies that can be detected with IgM […]

1749

Clinical-grade computational pathology using weakly supervised deep learning on whole slide images

The development of decision support systems for pathology and their deployment in clinical practice have been hindered by the need for large manually annotated datasets. To overcome this problem, the authors present a multiple instance learning-based deep learning system that uses only the reported diagnoses as labels for training, thereby avoiding expensive and time-consuming pixel-wise […]

1750

DefiniGEN launches tool to support in vitro intestinal research of Covid-19

UK-based iPSC (induced pluripotent stem cells) disease modelling company DefiniGEN has identified iPSC-derived intestinal organoids that could be used to help structure in vitro studies of the biology of SARS-CoV-2 infection across cohorts of multiple patients. While SARS-CoV-2 primarily targets the respiratory system, studies have shown that it also infects and multiplies within the intestinal […]