by Dr T. Truong, Dr J. Dien Bard and Dr R. Yee Nasopharyngeal swabs are recommended as the preferred sample type for detecting infection with SARS-CoV-2. However, there has been considerable interest in other collection methods, especially if they can circumvent supply shortages and the requirement for trained healthcare workers to administer them. Here we […]
by Dr O. Robertson-Gray and Dr W. Fuller Cardiovascular disease (CVD) is the umbrella term for conditions affecting the heart or blood vessels and remains the leading cause of death worldwide. New therapeutic strategies to aid in the prevention and treatment of CVD are therefore necessary. This article discusses the potential for S-acylation, a post-translational […]
by Dr Robert Reed and Dr Soheyl Tadjiki Viruses are increasingly used as gene therapy vectors in modern medicine. In order to minimize unwanted side effects such as immunogenicity, accurate determination of viral aggregation status is important. Field-flow fractionation is emerging as one of the most robust techniques for the separation and size measurement of […]
by Jean Deenmamode The concept of testing breath, blood or urine for alcohol is familiar to the general public, and blood alcohol testing is widely used across a range of industries, from aviation to driver licensing. But is a snapshot alcohol measurement really the best approach to ensuring longterm safety in these industries, or identifying […]
by Dr Nicolas Gerst Pipettes are important tools widely used in the lab. They are usually chosen and purchased carefully with the goal of receiving the best performance for a given price. Pipette tips are consumables; therefore, price can be an important factor, sometimes at the detriment of quality and performance. We found that tips […]
Histopathology is a crucial stage in the diagnosis of many diseases, particularly cancer staging and therapy management. Current challenges facing pathology are a shortage of pathologists and an increasing workload resulting from expanded screening programmes, increased test complexity and an increasing elderly population. Leeds Teaching Hospitals NHS Trust, UK, has a fully subspecialized diagnostic histopathology […]
by Dr Mustafa Yousif, Dr David S. McClintock and Dr Keluo Yao Artificial intelligence (AI) has the potential to optimize anatomic pathology (AP) laboratory efficiency, enhance pathologists’ diagnostic skills, elevate case reimbursement and, ultimately, improve patient care. To realize this potential, AP laboratories must overcome the barriers to adopting digital pathology (DP) while DP vendors […]
by Dr Ruth Ayling Calprotectin is a protein derived from neutrophils and its presence in feces can be used as a surrogate marker of gastrointestinal inflammation. Measurement is useful to differentiate inflammatory bowel disorder (IBD) from functional bowel disease, which has similar clinical features but different etiology, and to manage patients with established IBD.
by Dr Christina C. Pierre and Dr Lindsay Bazydlo Heparin-induced thrombocytopenia (HIT) is a hypercoagulable disorder that is mediated by antibodies against heparin complexed to platelet factor 4. HIT antibodies activate platelets, which generate a self-propagating, pro-coagulant state. A subset of patients with HIT develop thrombosis that can be limb- and/or life-threatening. This review provides […]
by Dr Jacqueline Gosink Tumour necrosis factor (TNF) inhibitors are increasingly used to treat chronic inflammatory bowel diseases, rheumatic diseases and psoriasis. Continuous drug level monitoring and administration interval adjustment accompanying the treatment with TNF inhibitors is the key to successful, individualized and targeted patient care. Concentrations of the TNF inhibitors adalimumab or infliximab can […]
December 2020 / January 2021
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