By Dr Maria Ada Prusicki Advances in whole-slide scanning technology enabled the automation of microscopy. Researchers can run image acquisition overnight and check the results remotely, minimizing the need for supervision and optimizing their use of time. Nonetheless, a few steps still require intense human supervision, especially for sample identification and scan area definition, where […]
by Dr Jacqueline Gosink In 2022, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) published a position paper on the management and follow-up of children and adolescents with coeliac disease (CD), following publication of new guidelines for the diagnosis of CD in 2020. This article discusses the different markers that can be used […]
by D. K. Cecconello, C. Rechenmacher, Prof. L. E. Daudt and M. B. Michalowski Acute lymphoblastic leukemia is the cancer most commonly found in children and asparaginase (ASNase) is used in the treatment. Our laboratory has been working to establish a regular analysis of ASNase activity in Brazil. Monitoring ASNase activity can be an important […]
Nicole M. Ondrush, PharmD, AAHIVP ; Bryan T. Mogle, PharmD, BCPS Vancomycin remains a mainstay of treatment for invasive infections caused by methicillin-resistant Staphylococcus aureus, and requires therapeutic drug monitoring (TDM) for optimal drug delivery. Herein, we discuss various methods of performing TDM for vancomycin, challenges associated with each method, and future directions for vancomycin […]
There are estimated to be more than 7000 rare genetic diseases (RGDs), which are defined as affecting less than 1 in 2000 people in Europe, many of which are monogenic. Although rare individually, collectively they affect 1 in 50 individuals. Diagnosis of these diseases is often very difficult and patients can remain undiagnosed or diagnosis […]
Spago Nanomedical AB (publ) today announced the publication of data on the composition, stability, and mode of action for its leading candidate drug 177Lu-SN201.
According to the World Health Organization, almost 15% of the world’s population is living with mental illness. We have medications that can be effective, but outcomes can vary. We caught up with Heather Read-Harper (Beckman Coulter) to find out more about the value of therapeutic drug monitoring in treating mental health disorders.
Autoantibodies against M-type phospholipase A2 receptors (PLA2Rab) are a central biomarker for diagnosis and monitoring of primary membranous nephropathy (pMN). PLA2Rab detection has recently been incorporated into the new KDIGO Clinical Practice Guideline for the Management of Glomerular Diseases. Diagnosis of pMN can now be made without biopsy if PLA2Rab are present alongside corresponding clinical […]
Enhanced leakiness of the blood–brain barrier has been associated with neurodegenerative disease, and assessing this leakiness has even been suggested as a possible method for early diagnosis of such disease. In light of the recent promising results from the lecanemab therapy for Alzheimer’s disease, CLI caught up with Dr Fiona McLean (University of Dundee, UK) […]
Awareness of the utility of wastewater for epidemiology was raised during the recent COVID-19 pandemic. CLI caught up with Dr Andrew Singer (UK Centre for Ecology & Hydrology) to find out more about the development of wastewater-based epidemiology and what it can do for us.