Therapeutic drug monitoring (TDM) of tacrolimus is mandatory because this immunosuppressive drug that is frequently prescribed in transplant patients, exhibits a high interpatient pharmacokinetic variability. This study explored the possibility of performing TDM using dried blood spots that can be collected by the patients themselves and that can be analysed by a fully-automated extraction module […]

In recent years, there has been a growing understanding of the pathology of autoimmune neurological disorders, and the identification of the causal autoantibodies has allowed the definition of new diseases. As these diseases have a multifaceted clinical presentation, comprehensive neural autoantibody testing is a central part of diagnosis. This article describe the current knowledge of […]

High-resolution mass spectrometry (MS) is a powerful analytical tool for clinical and forensic toxicology. It is capable of screening and confirming the presence of drugs and toxic compounds in various biological matrices. Using high-resolution MS/MS libraries helps to increase reporting confidence, verifies compound identification and reduces reporting of false-positive results.

The growth of molecular genetic technologies has enabled advances in personalized medicine, particularly in the field of cancer diagnosis, prognosis and therapeutic decision-making. CLI caught up with Dr Jennifer Keynton (Diagnostics R&D Manager at Horizon Discovery) to find out more about the development of tumour markers and the role of reference standards in cancer diagnostics […]

Histopathology has benefitted hugely from the digitization of whole slide imaging, allowing remote discussions (telepathology), image archiving which facilitates storage and retrieval, comparison of areas on different slides, and direct slide annotation. However, until recently, the selection of tissue from the slide for further downstream molecular analysis has still been a time-consuming, manual process. This […]