The acute porphyrias are a group of rare genetic metabolic disorders of the heme biosynthesis pathway, that result in the toxic accumulation of porphyrin precursors, notably porphobilinogen and delta-aminolevulinic acid. This article provides an overview of the biochemistry and the diagnosis of acute hepatic porphyria, which is crucial to managing this condition appropriately, preventing and […]
The growth of molecular genetic technologies has enabled advances in personalized medicine, particularly in the field of cancer diagnosis, prognosis and therapeutic decision-making. CLI caught up with Dr Jennifer Keynton (Diagnostics R&D Manager at Horizon Discovery) to find out more about the development of tumour markers and the role of reference standards in cancer diagnostics […]
The link between human papillomaviruses (HPVs) as the causal agents of anogenital warts and most incidences of cervical cancer has been longestablished, and it is in this background that the vaccine against HPV has been developed. However, more recently, HPV has also been found to be responsible for the increasing incidence and death from head, […]
Histopathology has benefitted hugely from the digitization of whole slide imaging, allowing remote discussions (telepathology), image archiving which facilitates storage and retrieval, comparison of areas on different slides, and direct slide annotation. However, until recently, the selection of tissue from the slide for further downstream molecular analysis has still been a time-consuming, manual process. This […]
Matrix-assisted laser desorption/ionization (MALDI) imaging is a technique that is on the cusp of revolutionizing histopathology. This article discusses the benefits of MALDI imaging and how it is beginning to be used in oncology, with particular relevance to the challenging area of lipid analysis.
During the course of the last 18 months, we have learned a lot about COVID-19, which was a new disease. It became apparent early on that one outcome of severe COVID-19 was acute respiratory distress syndrome (ARDS), with patients usually requiring mechanical ventilation. CLI caught up with Dr Anagh Vora (Senior Vice President and Chief […]
Anti-Müllerian hormone (AMH) plays a critical role in sex differentiation in fetal development and goes on to be important in the regulation of folliculogenesis in women. This article discusses the role of AMH in reproductive physiology and the many different situations where assessment of AMH levels is useful, as well as touching on methods of […]
This year marks the 30th anniversary of the founding of DiaSys Diagnostics Systems. CLI chatted to Dr Günther Gorka, Chief Executive Officer and Founder, about the company’s story and innovations.
Although the roll-out of the severe acute respiratory syndrome coronavirus 2 vaccination programme is proving effective at reducing levels of serious COVID-19 and associated deaths, the pandemic is by no means over. CLI caught up with Alina Merz (Senior Product Manager, Bruker Microbiology and Diagnostics) to find out more about why the need for new […]
It is estimated that around 1 in 6 couples have difficulty conceiving, with causes of infertility split equally between male and female factors. Although it is well known that a woman’s fertility declines sharply from the age of 35 onwards, it is perhaps less discussed that infertility also affects women in younger age groups (7% […]
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