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Clinical Laboratory int.

Archive for category: Featured Articles

Featured Articles

Molgen Lab

Unlocking the world through monitoring

, 28 March 2022/in Corona News, Editors' Picks, Featured Articles /by panglobal
by Niels Kruize, CCO, MolGen

“Automation and industrialization of COVID-19 PCR-testing will facilitate an immense scale-up of the global PCR-testing capacity. It will allow for a new approach to keep society open: preventive, regular testing (twice per week), which will create green bubbles and get us ahead of the curve” – Niels Kruize, CCO, MolGen

Molgen Lab

Why do we need PCR testing for monitoring?

To get ahead of the curve, we will need to change our methodology of COVID-19 testing. After two years, the pandemic continues to disrupt our way of life through the rise of new variants and outbreaks. The world has experienced several pandemic waves, subsequent lockdowns, and a variety of different policies per country and sometimes even per region. The regular discovery of new variants made us realize that we need to transition from infrequent, symptomatic patient testing, towards a more frequent testing approach, called monitoring. The Omicron variant shows us that the current system is under strain, as vaccines and updates to these vaccines become a pressing requirement to keep pace with new variants popping up. It is becoming clearer by the day that the way out of this pandemic demands us to take an even more pro-active role in testing to prevent the spread of the virus.

In diagnostics, scientists have long been aware that we need to move from incidental and individual diagnostic testing to regular interval testing for monitoring on a much larger scale. Monitoring will be instrumental in keeping our society open. People will be regularly tested (twice per week). This will increase the chance of early detection of a new case of infection before that person becomes infectious and participates in spreading the virus. Being able to then isolate the individual temporarily, will stop the spread of COVID-19 in its tracks or at least significantly slow it down.

At MolGen we are highly motivated to enable this for the world, but it will be instrumental to motivate people to see the need to get tested twice a week. For this to work we will have to lift the barriers to mass PCR-testing and make collecting a sample non-invasive and the costs to governments, employers and individuals far more affordable.

Molgen PurePrep TTR Buffers

How to lift barriers and make mass PCR-testing available and accessible
So how will we take away the public’s reluctance to get tested? We will have to take away the main barriers:

  1. Replace invasive nasal and throat swabs with a non-invasive sample collection method, using a Saliva Collection Kit.
  2. Make sample collection available at home, work, and any other location, instead of having to schedule an appointment at a local sampling location.
  3. Enabling the individual to easily link the sample to the person, without the fear of leaking or abuse of personal data, using our anonymous mobile app.
  4. Decrease the current costs of testing. By industrializing PCR-testing, the costs of a PCR-test will go down, making it suitable for mass monitoring purposes.

Molgen PurePrep TTR

MolGen’s MegaPrep is an innovative solution that contains solutions to all these 4 barriers. By working with leading laboratories across the Netherlands, Europe, and the world, the MegaPrep workflow uses the same principles as any other COVID-19 extraction and PCR detection workflow but is implemented on an industrial scale. A combination of smart innovations in automation and massive parallel PCR can handle much larger amounts of samples in a shorter timeframe at lower cost.

Our Saliva Collection Kit mixes saliva with a stabilization lysis transport buffer. This tube can be either collected in a dropbox or can be sent in a safety bag to a lab where the PCR testing is performed. The barcode on the tube combined with video recording of the sample collection in the MegaPrep will allow for non-invasive, safe & anonymous sample collection.

MegaPrep is handling up to a million samples a day
By making non-invasive testing available every 3-4 days, we are far more likely to detect an infected person before they become infectious. This means testing twice a week, every week. By accommodating this at the workplace, at the gym and in our schools, we can create what I call green bubbles. Monitoring using large scale PCR-testing is the safest way to create and maintain these safe bubbles.
I’m excited about all the possibilities created by MegaPrep. Non-invasive, cost-effective, and sensitive testing. MegaPrep will forge the future of testing and will be a key to unlocking our world.

  • Learn more about MolGen at molgen.com
https://clinlabint.com/wp-content/uploads/sites/2/2022/03/Molgen_Lab_02.jpg 1285 2000 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2022-03-28 12:41:482022-03-28 12:44:07Unlocking the world through monitoring

Mumps virus sequencing methods for high-resolution outbreak analysis

, 23 March 2022/in Featured Articles /by panglobal

Despite the enormous success of mumps vaccination campaigns around the world, there has recently been a significant increase in mumps cases and outbreaks in vaccinated populations. As a result, tracking the molecular epidemiology of mumps outbreaks has increased in importance. Here we examine the challenges and limitations associated with traditional molecular genotyping tools and compare […]

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High-sensitivity success for achy breaky hearts

, 23 March 2022/in Featured Articles /by panglobal

In May 2018, a rapid assessment and risk stratification pathway was implemented in Unscheduled Care for patients with suspected acute coronary syndrome, using high-sensitivity (hs) Troponin T. Patients could be ruled out and discharged within one hour of presentation to the Emergency Department. The assay was validated and its safety and clinical effectiveness assured through […]

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Approaches to solving gadolinium-based interference in selenium measurement

, 23 March 2022/in Featured Articles /by panglobal

Selenium (Se) is an essential trace element in many biological processes. Se is measured in many sample matrices. The gold standard Se measurement method is inductively coupled plasma mass spectrometry (ICP-MS). Monitoring alternative isotopes, applying correction factors, and utilizing ICP with a triple quadrupole mass spectrometer are approaches to mitigate the interference of doubly-charged gadolinium.

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Rapid supercritical fluid chromatography–tandem mass spectrometry (SFC-MS/MS) for the routine quantification of retinol and α-tocopherol in human serum and plasma

, 23 March 2022/in Featured Articles /by panglobal

As interest in vitamins A and E has increased in recent years, so too has the need for rapid and reliable methods by which these compounds can be assayed. The development of a supercritical fluid chromatography–tandem mass spectrometry (SFC-MS/MS)-based method with an automated extraction procedure provides faster analysis than other chromatographic-based methods and improved specificity.

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Use of laser-induced breakdown spectroscopy for rapid disease screening

, 23 March 2022/in Featured Articles /by panglobal

The COVID-19 pandemic demonstrated that in such situations there are some simple questions that benefit from fast answers: Who has got the disease; Who has had the disease; and Who remains unexposed. The technique of laser-induced breakdown spectroscopy has the potential to help answer these questions and we caught up with Professor Berlo (McGill University, […]

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Insight into advances in diagnosis of Barrett’s esophagus

, 18 January 2022/in Featured Articles /by panglobal

Barrett’s esophagus has been established as a pre-cancerous condition that increases an individual’s risk of developing esophageal cancer, and so regular monitoring people with Barrett’s esophagus can help improve the survival rates of those who develop cancer. However, diagnosis is usually by endoscopy, which is invasive, unpleasant and resource-intensive. CLI caught up with Charlene Tang […]

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Gastrointestinal Disorders: Literature Review

, 18 January 2022/in Featured Articles /by panglobal
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Therapeutic drug monitoring of favipiravir, a potential COVID-19 drug candidate

, 18 January 2022/in Featured Articles /by panglobal

The COVID-19 outbreak caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2) that was declared a pandemic in March 2020 has resulted in a the development of diagnostic tests and vaccines at an unprecedented speed. The development of de novo therapeutics, though, takes considerably longer, which is where the repurposing of existing drugs is being […]

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How the COVID-19 response was informed by – and informs – our battle against other global health crises

, 18 January 2022/in Featured Articles /by panglobal

The COVID-19 pandemic has reinforced the critical importance of diagnosis and access to these services, both at the individual and at a population level. The pandemic has also impacted the delivery of diagnostics and care for other medical conditions, such as HIV/AIDS, but similarly, lessons learned with COVID-19 can also be applied to improve diagnostic […]

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