Despite rapid advances in the areas of genomics and digital image analysis, cancer diagnosis remains largely reliant on tissue/cellular morphological assessment by an expert pathologist. Here, we summarize a newly developed approach to histology, based on a plasmon-induced colour change which provides instant, label-free visualization (or contrast) of cancer cells, distinguishing them from other cells […]
Therapeutic drug monitoring (TDM) of tacrolimus is mandatory because this immunosuppressive drug that is frequently prescribed in transplant patients, exhibits a high interpatient pharmacokinetic variability. This study explored the possibility of performing TDM using dried blood spots that can be collected by the patients themselves and that can be analysed by a fully-automated extraction module […]
The development of appropriate technical instrumentation for both sample and data analysis in recent years has driven progress in the field of metabolomics. CLI chatted to Dr Ali Tinazli (CEO at lifespin GmbH) to find out more about how this process of ‘digitizing health’ is developing and what it will mean for us as inidviduals.
In recent years, there has been a growing understanding of the pathology of autoimmune neurological disorders, and the identification of the causal autoantibodies has allowed the definition of new diseases. As these diseases have a multifaceted clinical presentation, comprehensive neural autoantibody testing is a central part of diagnosis. This article describe the current knowledge of […]
Recent advances are furthering our understanding of the role of iron in disease. CLI caught up with Professor Martina U. Muckenthaler and Dr Oriana Marques to learn more about the importance of iron homeostasis.
High-resolution mass spectrometry (MS) is a powerful analytical tool for clinical and forensic toxicology. It is capable of screening and confirming the presence of drugs and toxic compounds in various biological matrices. Using high-resolution MS/MS libraries helps to increase reporting confidence, verifies compound identification and reduces reporting of false-positive results.
The acute porphyrias are a group of rare genetic metabolic disorders of the heme biosynthesis pathway, that result in the toxic accumulation of porphyrin precursors, notably porphobilinogen and delta-aminolevulinic acid. This article provides an overview of the biochemistry and the diagnosis of acute hepatic porphyria, which is crucial to managing this condition appropriately, preventing and […]
The growth of molecular genetic technologies has enabled advances in personalized medicine, particularly in the field of cancer diagnosis, prognosis and therapeutic decision-making. CLI caught up with Dr Jennifer Keynton (Diagnostics R&D Manager at Horizon Discovery) to find out more about the development of tumour markers and the role of reference standards in cancer diagnostics […]
The link between human papillomaviruses (HPVs) as the causal agents of anogenital warts and most incidences of cervical cancer has been longestablished, and it is in this background that the vaccine against HPV has been developed. However, more recently, HPV has also been found to be responsible for the increasing incidence and death from head, […]
Histopathology has benefitted hugely from the digitization of whole slide imaging, allowing remote discussions (telepathology), image archiving which facilitates storage and retrieval, comparison of areas on different slides, and direct slide annotation. However, until recently, the selection of tissue from the slide for further downstream molecular analysis has still been a time-consuming, manual process. This […]