Waters Corporation has introduced TRIOS AutoPilot software from its TA Instruments Division for its thermal analyser product line. The software helps laboratory staff using TA’s thermal analysers create routine and streamlined standard operating procedures (SOPs) up to 25% faster, and avoid transcription errors that can inhibit productivity and can lead to inconsistent thermal analysis measurements […]
The fReactor Photo Flow – developed by Asynt, in conjunction with the University of Leeds (UK) – provides an easy-to-use, yet powerful platform for scientists looking to explore photochemistry in Flow Chemistry applications.
TRIMERO Diagnostics offers IVD CE urinary Cystatin C particle-enhanced immunoassays for Beckman Coulter’s IMMAGE series nephelometers and for the most popular clinical chemistry analyzers on the market.
Asynt, a leading supplier of affordable products, consumables and services for chemists in industry and academia, has introduced their Quadracell 4-position high pressure reactor – a new synthetic tool for scientists seeking the convenience of routine parallel pressure chemistry in a compact footprint.
Designed and manufactured in the UK, the robust Quadracell reactor is simple to set up and to operate, with heating and agitation provided by a standard magnetic hotplate stirrer and magnetic flea.
Constructed in durable stainless steel 316, the Quadracell has four cells – each with a reaction volume of 10 mL – that can routinely operate at temperatures up to 250 °C.
For labs using aggressive or caustic media, the Quadracell is optionally available constructed from Hastelloy C276 for enhanced chemical resistance.
Different versions of the Quadracell
Different versions of the Quadracell are available to safely operate up to your chosen maximum working pressure of 50, 100 or 200 Bar. Each Quadracell high pressure reactor is supplied with a pressure release valve, pressure gauge, gas inlet and gas outlet via two stainless steel needle valves.
With a wide range of accessories available, you can tailor the package to suit your exact chemistry and laboratory setup or select a standard Quadracell turn-key solution that’s ready to use right away.
The Quadracell is a new addition to the comprehensive range of single and multi-position high-performance pressure reactors from Asynt. To download a flyer providing a brief overview of the range, visit: Asynt Pressure Reactors
TRIMERO Diagnostics offers IVD CE urinary Cystatin C particle-enhanced immunoassays for Beckman Coulter’s IMMAGE series nephelometers and for the most popular clinical chemistry analyzers on the market.
As for other low molecular weight proteins, measurement of Cystatin C levels in urine may be a sensitive marker of tubular dysfunction, resulting from any cause or pathology (transplants, diabetes, poisoning, etc.), and according to some studies, Cystatin C shows some advantages compared to other proteins due to its stability and constant production rate.
In order to ensure lot-to-lot traceability, assays have been standardized to the European Reference Material for the Cystatin C (code: ERM-DA471/IFCC), of the Institute for Reference Materials and Measurements (IRMM).
Other assays for nephelometry and turbidimetry available from TRIMERO include:
For more information, visit: www.3diag.com
Siemens Healthineers is launching to laboratories Sysmex’s CN-3000 and CN-6000 Hemostasis Systems for mid- and high-volume coagulation testing. The company offers a broad menu of both routine and specialty coagulation assays that help identify blood coagulation disorders that can be performed on the Sysmex CN-3000 and CN-6000 Systems. This includes the new Siemens Healthineers’s INNOVANCE Anti-Xa assay for heparin and direct oral anticoagulant testing (DOAC).
“Siemens Healthineers and Sysmex’s 25-year partnership in hemostasis enables us to deliver both quality and comprehensive hemostasis testing solutions to laboratories of all sizes across the world,” said Deepak Nath, PhD, President of Laboratory Diagnostics for Siemens Healthineers.
Siemens Healthineers’s new INNOVANCE Anti-Xa assay is a ready-to-use, liquid-reagent heparin and DOAC assay. It delivers precise results without reagent reconstitution or waiting before use. The assay streamlines handling, reduces ordering complexity by enabling labs to test for heparin, as well as direct oral anticoagulants rivaroxaban and apixaban with one combined assay, and offers labs an economical testing solution for heparin and DOAC testing.
The Sysmex CN-3000 and CN-6000 Systems are designed to integrate with the Siemens Healthineers Atellica Data Manager and Aptio Automation to further streamline a hands-free workflow in the laboratory and to automate sample processing – including sample preparation as well as storage, refrigeration, and retrieval. With the ability to connect to Atellica Process Manager, labs can manage testing processes from a centralized location, while also gaining access to analytics to baseline and track key performance indicators such as turnaround time or problem samples. When connected to Atellica Data Manager, advanced algorithms can automatically determine the next steps in sample processing and routing helping labs to standardize testing protocols across multiple systems and locations.
CytoSMART Technologies has launched their new brightfield live-cell imaging system – the CytoSMART Lux3 BR. The small brightfield microscope is equipped with a high-quality 6.4 MP CMOS camera.
Like other CytoSMART microscopes, this new live-cell imager is designed to work inside a standard cell culture incubator without disturbing temperature, airflow, and optimum culture conditions for the cells. This allows researchers to perform long-term live-cell imaging experiments, ensuring optimal cell growth and health.
Very detailed brightfield images can be captured using the new device. With 2072 pixel resolution in both x- and y-axes, combined with 1.45 mm field of view, the microscope provides a resolution of 0.7 µm/pixel. Even at the commonly required image resolution of 300 dpi for printed publications, these images can fill the entire page without compromising image quality.
Jan-Willem van Bree, CTO at CytoSMART Technologies, commented: “We are very excited to expand our label-free microscopy solutions for live-cell studies. For cell biologists who want to incorporate live-cell imaging into their workflow, the resolution of live-cell imaging microscopes may be too low for accurately quantifying complex read-outs, such as cell tracking or differentiation processes. This causes inaccurate and variable results that compromise the research output. Unlike the high-end microscopes with incubation box, the Lux3 BR ensures that cultures are not exposed to temperature, humidity, or CO2 fluctuations that can stress the cells, as the device easily fits in every CO2-incubator. It is a powerful addition to each research lab.”
The CytoSMART Lux3 BR setup can be easily expanded to two or even four devices that can be operated and controlled individually via a single laptop. Since both Lux3 BR Duo Kit and Multi Lux3 BR devices can be placed directly next to each other in the same incubator, it allows for systematic comparison of control and treated samples, as all monitored cell cultures are maintained in an identical culture environment.
The main features and benefits of the CytoSMART Lux3 BR include:
For more information, visit: CytoSMART-Lux3-BR
Human cerebral cortex cryosections were stained with CF 405S GFAP Antibody (glial cells, cyan), then mounted with EverBrite Hardset with NucSpot 640, or EverBrite TrueBlack Hardset with NucSpot 640. Lipofuscin autofluorescence appears orange in the merged image and is effectively quenched after mounting in EverBrite TrueBlack. Nuclei are stained with NucSpot 640 (magenta).
Biotium, a leading provider of reagents for immunofluorescence microscopy, is significantly expanding its line of antifade wet-set and hardset EverBrite Mounting Medium with options that include Biotium’s new far-red NucSpot 640 nuclear counterstain. In addition, Biotium is also releasing EverBrite TrueBlack Hardset Mounting Medium for mounting and quenching of lipofuscin autofluorescence in a single step.
Antifade mounting media, like EverBrite, typically includes DAPI as a convenient blue nuclear counterstain for researchers performing immunofluorescence microscopy. However, cross-talk between fluorescence channels and UV-induced photoconversion of DAPI can cause bleed-through fluorescence in neighbouring FITC or Cy 3 channels. Biotium developed EverBrite Mounting Media with NucSpot counterstains as a novel solution to DAPI cross-talk and UV photoconversion, offering bright and specific nuclear imaging with very limited interference in other channels. EverBrite NucSpot 640 is specific for the Cy 5 channel.
Biotium’s TrueBlack lipofuscin quenchers are unique reagents designed to quench lipofuscin autofluorescence commonly found in human and aged animal tissues. New EverBrite TrueBlack Hardset Mounting Medium is the first reagent to offer both mounting and quenching of lipofuscin autofluorescence in a single step for greater convenience. EverBrite TrueBlack Hardset Mounting Medium will be available with DAPI, NucSpot 640, or without a nuclear counterstain.
“Mounting medium has traditionally only provided antifade properties and a convenient DAPI counterstain, but does little to address other issues with fluorescence,” says Lori Roberts PhD, Director of Bioscience at Biotium. “Our new EverBrite products aim to provide both convenience and novel research solutions for our customers.”
This release adds to Biotium’s growing portfolio of novel reagents for immunofluorescence microscopy, offering innovative solutions for all user workflows. Biotium’s new EverBrite with NucSpot and EverBrite TrueBlack Hardset Mounting Medium will be available in a standard 10 mL size or 2 mL trial size. NucSpot 640 nuclear counterstain is currently available with EverBrite Hardset and EverBrite TrueBlack Hardset Mounting Medium. Mounting media variations with NucSpot 680 for the Cy 5.5 channel will be released soon, according to the company.
Gyros Protein Technologies (part of Mesa Labs’ Biopharmaceutical Development Division), a pioneer in automated nanoliter-scale immunoassays and a leading provider of peptide synthesizers and reagents, has announced the next phase of its on-going collaboration with Cygnus Technologies, a Maravai LifeSciences company, and the introduction of a new HEK 293 HCP immunoassay solution. The Cygnus HEK 293 HCP Assay Reagent Set for Gyrolab is the first of a planned range of ready-to-use bioprocess impurity reagent sets optimized for use with the Gyrolab platform to be developed by Cygnus as part of the expanded collaboration.
The extension of the collaboration agreement follows the successful launch of the ready-to-use Gyrolab CHO HCP and E. coli HCP kits, developed through a licensing and supply agreement with Cygnus. The two companies are now expanding their relationship to develop a range of ready-to-use bioprocess impurity reagent sets optimized for use with the Gyrolab platform.
The HEK 293 HCP Assay Reagent Set for Gyrolab from Cygnus Technologies, designed for use with the Gyrolab Bioaffy 1000HC Toolbox, detects residual host cell protein (HCP) from HEK 293 cells, a cell line commonly used in viral vector production for cell and gene therapies as well as in manufacturing of vaccines. Together these combine to form the HEK 293 HCP Solution for Gyrolab. The automated nanoliter-scale immunoassay solution supports fast development and streamlined process transfer, increasing productivity, providing faster time to results with less hands-on time, and reduced sample volume and reagent consumption. The HEK 293 HCP Solution for Gyrolab enables researchers to generate more data in less time for a broader range of analytical applications.
“The collaboration with Cygnus Technologies is an exciting step for Gyros Protein Technologies, underscoring our commitment to provide leading-edge automated analysis solutions that support bioprocessing and manufacturing,” said Mark Vossenaar, Vice President, General Manager, Biopharmaceutical Development Division at Mesa Labs. “There is a real need for analytical tools that support fast turn-around time and small sample volume, to accelerate viral vector bioprocess workflows and reduce time to market. HEK 293 HCP Assay Reagent Set for Gyrolab is the first of this new, high quality range, and we hope to announce further releases in the near future.”
Sysmex Europe has launched two new automated blood coagulation analysers, CN-3500 and CN-6500, in specific countries in the EMEA region. They are targeted at medium- and large-scale hospitals and commercial labs, as well as other facilities, the company says.
The new instruments come with a measuring unit that uses the chemiluminescence enzyme immunoassay (CLEIA) methodology and incorporate all the unique features of their earlier automated blood coagulation analysers CN-3000/CN-6000, making it possible to measure blood coagulation testing parameters including molecular markers for blood coagulation with a single device.
“As a result the CN-3500/CN-6500 blood coagulation analysers allow for flexible measurements in response to a broad range of test orders in the fields of thrombosis and haemostasis, such as molecular markers for blood coagulation measured with CLEIA. This is in addition to the blood coagulation and platelet aggregation parameters, which can also be measured by the predecessors CN-6000 and CN-3000,” a Sysmex spokesperson said.
Sysmex notes that there has been an increase in thrombotic diseases due to ageing populations and changing lifestyles – and, as such, the field of haemostasis has seen more diverse demands for early-stage diagnosis and appropriate treatment of such conditions.
While the demand for greater diversity in testing and prompt provision of test results to physicians is on the rise, haemostasis is typically performed by using multiple instruments with different measurement principles, such as immunoassay systems and platelet aggregation analysers in addition to blood coagulation analysers, to measure different parameters. This not only adds to the complexity of the testing workflow, but also requires lengthy waits before test results become available to determine the disease state and provide appropriate medical care, posing challenges in healthcare settings.
The CN-3500/CN-6500 are integrated analysers which will significantly improve productivity, reliability, operability, and serviceability.
In future, the company says, they will invest in the development of IVD reagents for haemostasis and immunochemistry using CLEIA.
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