{"id":1011,"date":"2020-08-26T09:32:39","date_gmt":"2020-08-26T09:32:39","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/clues-about-immune-resolution-identified-in-blood\/"},"modified":"2021-01-08T11:09:15","modified_gmt":"2021-01-08T11:09:15","slug":"clues-about-immune-resolution-identified-in-blood","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/clues-about-immune-resolution-identified-in-blood\/","title":{"rendered":"Clues about immune resolution identified in blood"},"content":{"rendered":"<p><span lang=\"EN-GB\">Stopping a wound from bleeding is essential for human health. Blood coagulation \u2013 in which blood goes from liquid to gel and forms a clot \u2013 can prevent excessive bleeding and infection. But exactly what molecular events transpire when blood coagulates has remained somewhat mysterious. Using a new profiling procedure invented by investigators from Brigham and Women\u2019s Hospital permitted them to elucidate the role of immunoresolvents \u2013 molecules that help resolve inflammation and infections \u2013in blood coagulation, identifying a new cluster of these molecules that are produced when blood coagulates. <\/span><br \/>\n<span lang=\"EN-GB\">\u201cWe\u2019ve identified factors biosynthesized by human blood coagulation that elicit immune responses that protect the host,\u201d said corresponding author Charles N. Serhan, PhD, DSc. director and principal investigator at the Center for Experimental Therapeutics and Reperfusion Injury at BWH. \u201cOur results uncover a previously uncharacterized connection between the coagulation of blood and innate host defence mechanisms. We\u2019ve demonstrated for the first time how the innate immune response is connected to coagulation via novel pro-resolving mediators.\u201d<\/span><br \/>\n<span lang=\"EN-GB\">The new profiling procedure allowed the team to identify a cluster of immunoresolvents, namely resolvin D1, resolvin D5, resolvin E1, lipoxin B4 and maresin 1. These molecules activate immune cells called phagocytes, which can engulf and kill bacteria in the blood. Treating human blood with the components of this cluster of molecules discovered at BWH enhanced the abilities of phagocytes and helped the immune system attack E. coli, a common source of bacterial infection.<\/span><br \/>\n<span lang=\"EN-GB\">Interestingly, the newly developed profiling technique holds potential for profiling immunoresolvants in many contexts. The current study offers a glimpse of immunoresolvents found in the blood of healthy individuals, but the researchers are also interested in studying blood samples from patients with sepsis to pinpoint differences in immunoresolvents. Beyond blood, the research team also found a distinct profile of immunoresolvents in samples of healthy versus cancerous tissue from the testes \u2013 they note that this new profiling technique could potentially be used in the future to help distinguish between cancerous and healthy tissue from the testes or elsewhere in the body.<\/span><\/p>\n<p><span lang=\"EN-GB\">Brigham and Women\u2019s Hospital<\/span><br \/>\n<span lang=\"EN-GB\"><link https:\/\/bwhclinicalandresearchnews.org\/2017\/08\/04\/whats-new-in-research-august-2017-2\/ _blank external-link-new-window \"Opens external link in new window\">bwhclinicalandresearchnews.org\/2017\/08\/04\/whats-new-in-research-august-2017-2\/<\/link><\/span><br \/>\n<span lang=\"EN-GB\">&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stopping a wound from bleeding is essential for human health. Blood coagulation \u2013 in which blood goes from liquid to gel and forms a clot \u2013 can prevent excessive bleeding and infection. But exactly what molecular events transpire when blood coagulates has remained somewhat mysterious. Using a new profiling procedure invented by investigators from Brigham [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1011"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=1011"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1011\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=1011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=1011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=1011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}