{"id":1033,"date":"2020-08-26T09:32:39","date_gmt":"2020-08-26T09:32:39","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/seven-new-dna-regions-linked-to-kidney-cancer-risk\/"},"modified":"2021-01-08T11:09:20","modified_gmt":"2021-01-08T11:09:20","slug":"seven-new-dna-regions-linked-to-kidney-cancer-risk","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/seven-new-dna-regions-linked-to-kidney-cancer-risk\/","title":{"rendered":"Seven new DNA regions linked to kidney cancer risk"},"content":{"rendered":"<p><span lang=\"EN-GB\">Researchers have found seven new single-letter changes to DNA that are linked to an increased chance of developing renal cell carcinoma.&nbsp; <\/span>People with these variants are more likely to develop renal cell carcinoma, through the effect they have on nearby genes.<br \/>\n<span lang=\"EN-GB\">The study team, including researchers from The Institute of Cancer Research, London, have recently published their results.&nbsp; <\/span>As well as finding the seven new single-letter changes, they confirmed another six that had previously been put forward as risk factors for the disease.<br \/>\n<span lang=\"EN-GB\">Kidney cancer is the seventh most commonly diagnosed cancer in the UK, and renal cell carcinoma makes up 90 per cent of cases.<\/span><br \/>\n<span lang=\"EN-GB\">While much of the risk comes from lifestyle factors, genetics also plays a part. In total, the 13 genetic variants account for around 10 per cent of the inherited risk of renal cell carcinoma.<\/span><br \/>\n<span lang=\"EN-GB\">By comparing the DNA of 10,784 people with the disease and 20,406 people without, the team found that the seven new single-letter changes \u2013 as well as the six previously reported ones \u2013 were more likely to occur in people who developed renal cell carcinoma.<\/span><br \/>\n<span lang=\"EN-GB\">Further analysis allowed the team to suggest how these variants might be increasing risk of the disease.<\/span><br \/>\n<span lang=\"EN-GB\">For example, a single-letter change on chromosome 14 seems to affect the way that the instructions in a gene called DPF3 are carried out. That gene is involved in the production of proteins that affect the packaging of DNA \u2013 and errors in these proteins are often found in tumours.<\/span><br \/>\n<span lang=\"EN-GB\">Professor Richard Houlston, Professor of Molecular and Population Genetics at the ICR, was one of the study\u2019s lead authors. He said: \u201cOur analysis provides further evidence that a person\u2019s susceptibility to renal cell carcinoma is linked to the combined effect of multiple genetic mutations.<\/span><\/p>\n<p><span lang=\"EN-GB\">Institute of Cancer Research<\/span><br \/>\n<span lang=\"EN-GB\"><link http:\/\/www.icr.ac.uk\/news-archive\/seven-new-dna-regions-linked-to-kidney-cancer-risk?via=carousel0024 _blank external-link-new-window \"Opens external link in new window\">www.icr.ac.uk\/news-archive\/seven-new-dna-regions-linked-to-kidney-cancer-risk?via=carousel0024<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have found seven new single-letter changes to DNA that are linked to an increased chance of developing renal cell carcinoma.&nbsp; People with these variants are more likely to develop renal cell carcinoma, through the effect they have on nearby genes. The study team, including researchers from The Institute of Cancer Research, London, have recently [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1033"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=1033"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1033\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=1033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=1033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=1033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}