{"id":1047,"date":"2020-08-26T09:32:39","date_gmt":"2020-08-26T09:32:39","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/five-years-before-brain-cancer-diagnosis-changes-detectable-in-blood\/"},"modified":"2021-01-08T11:09:25","modified_gmt":"2021-01-08T11:09:25","slug":"five-years-before-brain-cancer-diagnosis-changes-detectable-in-blood","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/five-years-before-brain-cancer-diagnosis-changes-detectable-in-blood\/","title":{"rendered":"Five years before brain cancer diagnosis, changes detectable in blood"},"content":{"rendered":"

Interactions among proteins that relay information from one immune cell to another are weakened in the blood of brain cancer patients within five years before the cancer is diagnosed, said lead researcher Judith Schwartzbaum of The Ohio State University.<\/span>
\nThat information could one day lead to earlier diagnosis of brain cancer, said Schwartzbaum, an associate professor of epidemiology and member of Ohio State\u2019s Comprehensive Cancer Center.<\/span>
\nThe study focused on gliomas, which make up about 80 percent of brain cancer diagnoses. Average survival time for the most common type of glioma is 14 months.<\/span>
\nSymptoms vary and include headaches, memory loss, personality changes, blurred vision and difficulty speaking. On average, the cancer is diagnosed three months after the onset of symptoms and when tumours are typically advanced.<\/span>
\n\u201cIt\u2019s important to identify the early stages of tumour development if we hope to intervene more effectively,\u201d Schwartzbaum said. \u201cIf you understand those early steps, maybe you can design treatments to block further tumour growth.\u201d<\/span>
\nWhile widespread blood testing of people without symptoms of this rare tumour would be impractical, this research could pave the way for techniques to identify brain cancer earlier and allow for more-effective treatment, Schwartzbaum said.<\/span>
\nSchwartzbaum evaluated blood samples from 974 people, half of whom went on to receive a brain-cancer diagnosis in the years after their blood was drawn. The samples came from Norway\u2019s Janus Serum Bank.<\/span>
\nBecause of previous research \u2013 including her own on the relationship between allergies and brain cancer \u2013 Schwartzbaum was interested in the role of cytokines, proteins that communicate with one another and with immune cells to spark immune responses. Schwartzbaum\u2019s previous work found that allergies appeared to offer protection against brain cancer.<\/span>
\nIn this study, Schwartzbaum evaluated 277 cytokines in the blood samples and found less cytokine interaction in the blood of people who developed cancer.<\/span>
\n\u201cThere was a clear weakening of those interactions in the group who developed brain cancer and it\u2019s possible this plays a role in tumour growth and development,\u201d Schwartzbaum said.<\/span>
\nCytokine activity in cancer is especially important to understand because it can play a good-guy role in terms of fighting tumour development, but it also can play a villain and support a tumour by suppressing the immune system, she said.<\/span>
\nIn addition to discovering the weakening of cytokine interactions in the blood of future cancer patients, the researchers found a handful of cytokines that appear to play an especially important role in glioma development.<\/span>
\nThe results of this study must be confirmed and further evaluated before it could translate to changes in the earlier diagnosis of brain cancer, but the discovery offers important insights, Schwartzbaum said.<\/span>
\n\u201cIt\u2019s possible this could also happen with other tumours \u2013 that this is a general sign of tumour development,\u201d she said.<\/p>\n

<\/span>
\nOhio State Universityhttps:\/\/news.osu.edu\/news\/2015\/09\/09\/a-hint-of-increased-brain-tumor-risk-5-years-before-diagnosis\/<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Interactions among proteins that relay information from one immune cell to another are weakened in the blood of brain cancer patients within five years before the cancer is diagnosed, said lead researcher Judith Schwartzbaum of The Ohio State University. That information could one day lead to earlier diagnosis of brain cancer, said Schwartzbaum, an associate […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-1047","post","type-post","status-publish","format-standard","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1047"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=1047"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1047\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=1047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=1047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=1047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}