{"id":1074,"date":"2020-08-26T09:33:00","date_gmt":"2020-08-26T09:33:00","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/scientists-name-connshing-syndrome-as-a-new-cause-of-high-blood-pressure\/"},"modified":"2021-01-08T11:09:31","modified_gmt":"2021-01-08T11:09:31","slug":"scientists-name-connshing-syndrome-as-a-new-cause-of-high-blood-pressure","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/scientists-name-connshing-syndrome-as-a-new-cause-of-high-blood-pressure\/","title":{"rendered":"Scientists name &#8216;Connshing syndrome&#8217; as a new cause of high blood pressure"},"content":{"rendered":"<p><span lang=\"EN-GB\">Research led by scientists at the University of Birmingham has revealed a new cause of high blood pressure which could lead to major changes in managing the disease.<\/span><br \/>\n<span lang=\"EN-GB\">High blood pressure, also known as hypertension, often goes unnoticed but if left untreated can increase the risk of heart attack and stroke.<\/span><br \/>\n<span lang=\"EN-GB\">Studies estimate that one in four adults suffer from hypertension, but most patients have no identifiable cause for the condition.<\/span><br \/>\n<span lang=\"EN-GB\">However, it is known that in up to 10 per cent of hypertensive patients the overproduction of the adrenal hormone aldosterone &#8211; a condition known as primary aldosteronism or Conn syndrome &#8211; is the cause of disease.<\/span><br \/>\n<span lang=\"EN-GB\">Now the University of Birmingham-led study has, for the first time, made the important discovery that a large number of patients with Conn syndrome do not only overproduce aldosterone but also the stress hormone cortisol.<\/span><br \/>\n<span lang=\"EN-GB\">Professor Wiebke Arlt, Director of the Institute of Metabolism and Systems Research (IMSR) at the University of Birmingham, said: \u201cOur findings show that the adrenal glands of many patients with Conn syndrome also produce too much cortisol, which finally explains puzzling results of previous studies in Conn patients.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cThese previous studies had found increased rates of type 2 diabetes, osteoporosis and depression in Conn patients \u2013 problems typically caused by overproduction of cortisol, also termed Cushing syndrome, and not by too much aldosterone.\u201d<\/span><br \/>\n<span lang=\"EN-GB\">The authors of the University of Birmingham-led study, conducted in collaboration with a group of scientists from Germany, decided to name this new cause of hypertension &#8211; the combined overproduction of aldosterone and cortisol &#8211; as Connshing syndrome.<\/span><br \/>\n<span lang=\"EN-GB\">At present, many Conn syndrome patients are treated with drugs that are directed against the adverse effects of aldosterone. However, this leaves the cortisol excess untreated.<\/span><br \/>\n<span lang=\"EN-GB\">Second author of the study, published in JCI Insight, Dr Katharina Lang \u2013 an academic clinical lecturer at IMSR \u2013 said: \u201cThese findings are very likely to change clinical practice.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cPatients will now need to undergo more detailed assessment to clarify whether they suffer from Conn or Connshing syndrome.<\/p>\n<p><\/span><br \/>\n<span lang=\"EN-GB\">University of Birmingham<\/span><br \/>\n<span lang=\"EN-GB\"><link http:\/\/www.birmingham.ac.uk\/news\/latest\/2017\/04\/connshing-syndrome.aspx>www.birmingham.ac.uk\/news\/latest\/2017\/04\/connshing-syndrome.aspx<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research led by scientists at the University of Birmingham has revealed a new cause of high blood pressure which could lead to major changes in managing the disease. High blood pressure, also known as hypertension, often goes unnoticed but if left untreated can increase the risk of heart attack and stroke. Studies estimate that one [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-1074","post","type-post","status-publish","format-standard","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1074"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=1074"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1074\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=1074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=1074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=1074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}