{"id":1200,"date":"2020-08-26T09:33:21","date_gmt":"2020-08-26T09:33:21","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/new-analytical-tool-for-fluorescence-detection-of-double-stranded-rna\/"},"modified":"2021-01-08T11:10:01","modified_gmt":"2021-01-08T11:10:01","slug":"new-analytical-tool-for-fluorescence-detection-of-double-stranded-rna","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/new-analytical-tool-for-fluorescence-detection-of-double-stranded-rna\/","title":{"rendered":"New analytical tool for fluorescence detection of double-stranded RNA"},"content":{"rendered":"<p>Ribonucleic acid (RNA) binding fluorescent probes have been powerful and important analytical tools for the study of RNA structures and functions.<\/p>\n<p>A research group led by Professor Seiichi Nishizawa at Tohoku University&#8217;s Graduate School of Science has reported a new RNA probe that binds to double-stranded RNA (dsRNA) in a sequence-specific manner.<\/p>\n<p>The probe has a weak response to mismatch-containing dsRNA sequences, thus enabling sequence-selective fluorescence sensing of dsRNA at the single-base pair resolution. It also shows a preference for binding with dsRNA over dsDNA, which is an important selective process for future applications in a cellular environment where RNA and DNA co-exist.<\/p>\n<p>In contrast to the conventional analytical method which is limited to single-stranded regions of RNA, the new analytical method allows for fluorescent sensing of target dsRNA structure and sequence for the first time.<\/p>\n<p>It is expected that the probe will open up new possibilities for analysing the functions of dsRNA-containing structures, which are closely related to various biological phenomena and diseases.<\/p>\n<p>Tohoku University\n<link http:\/\/www.tohoku.ac.jp\/en\/press\/fluorescence_detection_of_rna.html _blank external-link-new-window>www.tohoku.ac.jp\/en\/press\/fluorescence_detection_of_rna.html<\/link>\n","protected":false},"excerpt":{"rendered":"<p>Ribonucleic acid (RNA) binding fluorescent probes have been powerful and important analytical tools for the study of RNA structures and functions. A research group led by Professor Seiichi Nishizawa at Tohoku University&#8217;s Graduate School of Science has reported a new RNA probe that binds to double-stranded RNA (dsRNA) in a sequence-specific manner. The probe has [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1200"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=1200"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1200\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=1200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=1200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=1200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}