You are a patient who has just been treated for a serious illness but neither you nor your doctor knows how likely it is that you \u2013 in comparison with other patients — will actually be helped by the treatment. This is often the situation with prostate cancer, one of the deadliest and most highly prevalent cancers. While hormone therapy can help, patient responses vary widely, and it\u2019s still unclear why some types of prostate cancer seem to be resistant to the therapy.<\/p>\n
A team led by Associate Professor Lloyd Trotman at Cold Spring Harbor Laboratory (CSHL) shows how signalling by an immune system component called interleukin-6 (IL-6) appears to play an important role in driving particularly aggressive and therapy-resistant prostate cancer. <\/p>\n
\u201cOur research suggests that IL-6 could be a marker for when the disease switches to a more dangerous state that is ultimately hormone therapy-resistant,\u201d says Trotman.<\/p>\n
The results could have important implications for human prostate cancer. \u201cThe gain could be immense, because today’s problem is that the variability in response of humans to hormone therapy is amazing,\u201d Trotman says. \u201cFor one man this therapy might be great, might reduce disease burden dramatically for many, many, years, and be an extreme benefit,\u201d he says. \u201cFor others there’s almost no response, and it’s still not clear to clinicians who is who.\u201d<\/p>\n
Being able to predict which patients would benefit from hormone therapy \u201cwould be amazing,\u201d Trotman says. \u201cWe are really hopeful that translating the IL-6 discovery into the clinics could help us stratify patients into good responders and bad responders. For any hospital this would be a major breakthrough.\u201d<\/p>\n
Trotman and his team, which included Dawid Nowak, Ph.D., a postdoctoral investigator who is the paper’s first author, looked for cellular signals that led to metastasis and hormone therapy resistance in a genetically engineered mouse model for metastatic prostate cancer. They found that the combined loss of two genes, PTEN and p53 — closely associated with prostate cancer metastasis — led to the secretion of IL-6. Signalling by IL-6 was then responsible for activating a powerful cancer gene called MYC, which drives cell proliferation and disease progression. <\/p>\n
\u201cIt suggested immediately that cell-cell communication is very, very important to make the cells resistant to therapy and very aggressive,\u201d says Trotman.<\/p>\n
The involvement of the MYC pathway suggests that it could potentially serve as a target of drugs against prostate cancer, Trotman says. The team\u2019s next step is to study IL-6 signalling in humans. \u201cIL-6 detection in blood has been developed to a high art,\u201d Trotman says. \u201cThere are very good tools, which have been tested in the hospital setting.\u201d \nCold Spring Harbor Laboratory <\/link>\n","protected":false},"excerpt":{"rendered":"
You are a patient who has just been treated for a serious illness but neither you nor your doctor knows how likely it is that you \u2013 in comparison with other patients — will actually be helped by the treatment. This is often the situation with prostate cancer, one of the deadliest and most highly […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1399"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=1399"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1399\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=1399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=1399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=1399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}