{"id":15393,"date":"2021-09-03T09:46:29","date_gmt":"2021-09-03T09:46:29","guid":{"rendered":"https:\/\/clinlabint.com\/?p=15393"},"modified":"2021-09-03T09:47:06","modified_gmt":"2021-09-03T09:47:06","slug":"clsi-publishes-new-document-c64-quantitative-measurement-of-proteins-and-peptides-by-mass-spectrometry-1st-edition","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/clsi-publishes-new-document-c64-quantitative-measurement-of-proteins-and-peptides-by-mass-spectrometry-1st-edition\/","title":{"rendered":"CLSI publishes new document C64 \u2013 Quantitative Measurement of Proteins and Peptides by Mass Spectrometry, 1st edition"},"content":{"rendered":"<div id='av_section_1'  class='avia-section main_color avia-section-default avia-no-border-styling  avia-bg-style-scroll  avia-builder-el-0  avia-builder-el-no-sibling   container_wrap fullsize' style=' '  ><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-15393'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fifth  av-hide-on-mobile  flex_column_div av-zero-column-padding first  avia-builder-el-1  el_before_av_three_fifth  avia-builder-el-first  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\"><!--Begin ClixTrac.com Banner Code -->\r\n<a href=\"https:\/\/clixtrac.com\/goto\/?311442\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/clixtrac.com\/banner\/311442.jpg\" alt=\"Bio-Rad - Preparing for a Stress-free QC Audit\" title=\"Bio-Rad - Preparing for a Stress-free QC Audit\" border=\"0\" \/><\/a>\r\n<!--End ClixTrac.com Banner Code --><\/p>\n<\/div><\/section><\/div><div class=\"flex_column av_three_fifth  flex_column_div av-zero-column-padding   avia-builder-el-3  el_after_av_one_fifth  el_before_av_one_fifth  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\"><\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><header class=\"entry-content-header\"><h1 class=\"post-title entry-title\" itemprop=\"headline\">CLSI publishes new document C64 \u2013 Quantitative Measurement of Proteins and Peptides by Mass Spectrometry, 1st edition<\/h1><span class=\"post-meta-infos\">\/ <span class=\"blog-categories minor-meta\">in <a href=\"https:\/\/clinlabint.com\/e-news\/\" rel=\"tag\">E-News<\/a> <\/span><\/span><\/header>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>CLSI publishes new document C64 \u2013 Quantitative Measurement of Proteins and Peptides by Mass Spectrometry, 1st edition<\/h3>\n<p><!--more--><\/p>\n<p>The Clinical and Laboratory Standards Institute (CLSI) has published the first edition of C64 \u2013 Quantitative Measurement of Proteins and Peptides by Mass Spectrometry. C64 provides a framework for developing clinical protein and peptide assays from conception to validation and is intended for those who have experience with traditional small-molecule liquid chromatography\u2013mass spectrometry (LC-MS) but not with protein and peptide analysis. Although closely related to traditional small-molecule analysis by LC-MS, protein and peptide analysis involves unique challenges and necessitates complex workflows, which are covered in detail. To enhance translation of assays to clinical use, this guideline focuses on method development aligned with clinically appropriate analytical validation.<\/p>\n<p>This guideline also discusses:<br \/>\n\u2022 Effective use of internal standards.<br \/>\n\u2022 Quality control and proficiency testing<br \/>\nmaterials.<br \/>\n\u2022 Feasibility determination and planning.<br \/>\n\u2022 Approaches to calibration.<\/p>\n<\/div><\/section><br \/>\n<div  class='av-social-sharing-box  avia-builder-el-7  el_after_av_textblock  avia-builder-el-last  av-social-sharing-box-minimal '><div class='av-share-box'><h5 class='av-share-link-description av-no-toc '>Share this<\/h5><ul class='av-share-box-list noLightbox'><li class='av-share-link av-social-link-facebook' ><a target=\"_blank\" aria-label=\"Share on Facebook\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https:\/\/clinlabint.com\/clsi-publishes-new-document-c64-quantitative-measurement-of-proteins-and-peptides-by-mass-spectrometry-1st-edition\/&#038;t=CLSI%20publishes%20new%20document%20C64%20%E2%80%93%20Quantitative%20Measurement%20of%20Proteins%20and%20Peptides%20by%20Mass%20Spectrometry%2C%201st%20edition\" aria-hidden=\"false\" data-av_icon=\"\ue8f3\" data-av_iconfont=\"entypo-fontello\" title=\"\" data-avia-related-tooltip=\"Share on Facebook\" rel=\"noopener\"><span class='avia_hidden_link_text'>Share on Facebook<\/span><\/a><\/li><li class='av-share-link av-social-link-twitter' ><a target=\"_blank\" aria-label=\"Share on Twitter\" href=\"https:\/\/twitter.com\/share?text=CLSI%20publishes%20new%20document%20C64%20%E2%80%93%20Quantitative%20Measurement%20of%20Proteins%20and%20Peptides%20by%20Mass%20Spectrometry%2C%201st%20edition&#038;url=https:\/\/clinlabint.com\/?p=15393\" aria-hidden=\"false\" data-av_icon=\"\ue8f1\" data-av_iconfont=\"entypo-fontello\" title=\"\" data-avia-related-tooltip=\"Share on Twitter\" rel=\"noopener\"><span class='avia_hidden_link_text'>Share on Twitter<\/span><\/a><\/li><li class='av-share-link av-social-link-whatsapp' ><a target=\"_blank\" aria-label=\"Share on WhatsApp\" href=\"https:\/\/api.whatsapp.com\/send?text=https:\/\/clinlabint.com\/clsi-publishes-new-document-c64-quantitative-measurement-of-proteins-and-peptides-by-mass-spectrometry-1st-edition\/\" aria-hidden=\"false\" data-av_icon=\"\uf232\" data-av_iconfont=\"entypo-fontello\" title=\"\" data-avia-related-tooltip=\"Share on WhatsApp\" rel=\"noopener\"><span class='avia_hidden_link_text'>Share on WhatsApp<\/span><\/a><\/li><li class='av-share-link av-social-link-linkedin' ><a target=\"_blank\" aria-label=\"Share on LinkedIn\" href=\"https:\/\/linkedin.com\/shareArticle?mini=true&#038;title=CLSI%20publishes%20new%20document%20C64%20%E2%80%93%20Quantitative%20Measurement%20of%20Proteins%20and%20Peptides%20by%20Mass%20Spectrometry%2C%201st%20edition&#038;url=https:\/\/clinlabint.com\/clsi-publishes-new-document-c64-quantitative-measurement-of-proteins-and-peptides-by-mass-spectrometry-1st-edition\/\" aria-hidden=\"false\" data-av_icon=\"\ue8fc\" data-av_iconfont=\"entypo-fontello\" title=\"\" data-avia-related-tooltip=\"Share on LinkedIn\" rel=\"noopener\"><span class='avia_hidden_link_text'>Share on LinkedIn<\/span><\/a><\/li><li class='av-share-link av-social-link-mail' ><a  aria-label=\"Share by Mail\" href='mailto:?subject=CLSI%20publishes%20new%20document%20C64%20%E2%80%93%20Quantitative%20Measurement%20of%20Proteins%20and%20Peptides%20by%20Mass%20Spectrometry%2C%201st%20edition&#038;body=https:\/\/clinlabint.com\/clsi-publishes-new-document-c64-quantitative-measurement-of-proteins-and-peptides-by-mass-spectrometry-1st-edition\/' aria-hidden='false' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' title='' data-avia-related-tooltip='Share by Mail'><span class='avia_hidden_link_text'>Share by Mail<\/span><\/a><\/li><\/ul><\/div><\/div><\/p><\/div><div class=\"flex_column av_one_fifth  av-hide-on-mobile  flex_column_div av-zero-column-padding   avia-builder-el-8  el_after_av_three_fifth  avia-builder-el-last  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\"><\/p>\n<\/div><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>CLSI publishes new document C64 \u2013 Quantitative Measurement of Proteins and Peptides by Mass Spectrometry, 1st edition<\/p>\n","protected":false},"author":3,"featured_media":15209,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/15393"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=15393"}],"version-history":[{"count":2,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/15393\/revisions"}],"predecessor-version":[{"id":15395,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/15393\/revisions\/15395"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media\/15209"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=15393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=15393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=15393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}