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Navigo, Mannin agree to develop affinity ligand against a novel drug for treatment of COVID-19<\/h1>E-News<\/a> <\/span><\/span><\/header>\n<\/div><\/section>
\nNavigo Proteins, a premier protein engineering company and developer of affinity ligands for custom chromatography solutions and Mannin, a subsidiary of Mannin Research Inc. (MRI), have agreed to develop a Precision X affinity ligand against the fusion protein of Angiopoietin-1 and Complement 4 Binding Protein (ANG1-C4BP) for use in GMP manu\u00adfacturing. Mannin, and its parent MRI, are developing the Ang1-C4bp therapeutic as first-in-class treatment in addressing the unmet needs of patients in Acute Respiratory Disease, glaucoma, and kidney disease.<\/h3>\n<\/p>\n
The Ang1-C4bp recombinant protein is a therapeutic that acts to specifically, and potently activate the Tie2 receptor, a part of the Ang1-Tie2 mechanism of action (MoA). Clinical studies have shown that drugs targeting this MoA improve patient outcomes with severe infections from infectious diseases, such as COVID-19. If left untreated, the most severe patients can develop Acute Respiratory Disease Syndrome (ARDS), leading to systemic organ failure and death. Through activation of the Ang1-Tie2 MoA, the Ang1-C4bp therapeutic would be addressing the vascular dysfunction caused by the infectious disease, ultimately improving patient outcomes such as days on ventilator, weight loss, days in hospital, and reduction in death.<\/p>\n
The precision capturing technology notably enables affinity purification for proteins beyond antibodies de-risking downstream process development and assuring a robust and scalable process for clinical development as well as commercialization. The development of this affinity ligand thus aides in the acceleration of process development timelines to support Mannin in their mission to rapidly develop the therapeutic for ARDS patients, and further develop their therapeutic platform for additional indications, in the cardiovascular space and beyond.<\/p>\n<\/div><\/section>
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Navigo Proteins, a premier protein engineering company and developer of affinity ligands for custom chromatography solutions and Mannin, a subsidiary of Mannin Research Inc. (MRI), have agreed to develop a Precision X affinity ligand against the fusion protein of Angiopoietin-1 and Complement 4 Binding Protein (ANG1-C4BP) for use in GMP manu\u00adfacturing. Mannin, and its parent MRI, are developing the Ang1-C4bp therapeutic as first-in-class treatment in addressing the unmet needs of patients in Acute Respiratory Disease, glaucoma, and kidney disease.<\/h3>\n<\/p>\n
The Ang1-C4bp recombinant protein is a therapeutic that acts to specifically, and potently activate the Tie2 receptor, a part of the Ang1-Tie2 mechanism of action (MoA). Clinical studies have shown that drugs targeting this MoA improve patient outcomes with severe infections from infectious diseases, such as COVID-19. If left untreated, the most severe patients can develop Acute Respiratory Disease Syndrome (ARDS), leading to systemic organ failure and death. Through activation of the Ang1-Tie2 MoA, the Ang1-C4bp therapeutic would be addressing the vascular dysfunction caused by the infectious disease, ultimately improving patient outcomes such as days on ventilator, weight loss, days in hospital, and reduction in death.<\/p>\n
The precision capturing technology notably enables affinity purification for proteins beyond antibodies de-risking downstream process development and assuring a robust and scalable process for clinical development as well as commercialization. The development of this affinity ligand thus aides in the acceleration of process development timelines to support Mannin in their mission to rapidly develop the therapeutic for ARDS patients, and further develop their therapeutic platform for additional indications, in the cardiovascular space and beyond.<\/p>\n<\/div><\/section>
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