{"id":18994,"date":"2023-03-15T13:36:54","date_gmt":"2023-03-15T13:36:54","guid":{"rendered":"https:\/\/clinlabint.com\/?p=18994"},"modified":"2023-03-15T13:38:04","modified_gmt":"2023-03-15T13:38:04","slug":"owlstone-medical-enters-partnership-with-bicycle-therapeutics-for-the-development-of-antigen-targeted-evoc-probes-for-early-cancer-detection","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/owlstone-medical-enters-partnership-with-bicycle-therapeutics-for-the-development-of-antigen-targeted-evoc-probes-for-early-cancer-detection\/","title":{"rendered":"Owlstone Medical Enters Partnership with Bicycle Therapeutics for the Development of Antigen-Targeted EVOC Probes for Early Cancer Detection"},"content":{"rendered":"<div id='av_section_1'  class='avia-section main_color avia-section-default avia-no-border-styling  avia-bg-style-scroll  avia-builder-el-0  avia-builder-el-no-sibling   container_wrap fullsize' style=' '  ><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-18994'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fifth  av-hide-on-mobile  flex_column_div av-zero-column-padding first  avia-builder-el-1  el_before_av_three_fifth  avia-builder-el-first  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center\"><!--Begin ClixTrac.com Banner Code -->\r\n<a href=\"https:\/\/clixtrac.com\/goto\/?311442\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/clixtrac.com\/banner\/311442.jpg\" alt=\"Bio-Rad - Preparing for a Stress-free QC Audit\" title=\"Bio-Rad - Preparing for a Stress-free QC Audit\" border=\"0\" \/><\/a>\r\n<!--End ClixTrac.com Banner Code --><\/p>\n<\/div><\/section><\/div><div class=\"flex_column av_three_fifth  flex_column_div av-zero-column-padding   avia-builder-el-3  el_after_av_one_fifth  el_before_av_one_fifth  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center\"><\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><header class=\"entry-content-header\"><h1 class=\"post-title entry-title\" itemprop=\"headline\">Owlstone Medical Enters Partnership with Bicycle Therapeutics for the Development of Antigen-Targeted EVOC Probes for Early Cancer Detection<\/h1><span class=\"post-meta-infos\">\/ <span class=\"blog-categories minor-meta\">in <a href=\"https:\/\/clinlabint.com\/e-news\/\" rel=\"tag\">E-News<\/a>  <\/span><\/span><\/header>\n<\/div><\/section><br \/>\n<div  class='avia-image-container  av-styling-    avia-builder-el-6  el_after_av_textblock  el_before_av_textblock  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img decoding=\"async\" class=\"avia_image\" src=\"https:\/\/clinlabint.com\/wp-content\/uploads\/sites\/2\/2023\/03\/image001.png\" alt=\"\" title=\"image001\" height=\"100\" width=\"140\" itemprop=\"thumbnailUrl\"><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><ul>\n<li>\n<h3><em>Research will focus on applying Bicycle\u2019s bicyclic peptide technology to Owlstone\u2019s EVOC Probes<\/em><\/h3>\n<\/li>\n<li>\n<h3><em>Antigen-targeted EVOC Probes have potential for use in preclinical research, clinical trials, and as companion diagnostics and tests for early detection of disease<\/em><\/h3>\n<\/li>\n<li>\n<h3><em>Initial research will focus on the early detection of lung cancer<\/em><\/h3>\n<\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>Owlstone Medical (\u201cOwlstone\u201d), the global leader in Breath Biopsy<sup>\u00ae<\/sup> for applications in early disease detection and precision medicine, today announced that it has entered into a Research Agreement with Bicycle Therapeutics plc (NASDAQ: BCYC, \u201cBicycle\u201d), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle<sup>\u00ae<\/sup>) technology.<\/p>\n<p>Under the Agreement, the Companies will investigate the potential of combining technologies and methods to develop antigen-targeted diagnostic probes that use bicyclic peptides as their targeting mechanism linked with Owlstone\u2019s Exogenous Volatile Organic Compound (EVOC<sup>\u00ae<\/sup>) Probes. Work will initially focus on lung cancer screening as the first proof of principle for the broader opportunity by promoting selective accumulation of the probe at the tumor for increased signal and enhanced specificity.<\/p>\n<\/div><\/section><br \/>\n<div  class='avia-image-container  av-styling-    avia-builder-el-8  el_after_av_textblock  el_before_av_textblock  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img decoding=\"async\" class=\"avia_image\" src=\"https:\/\/clinlabint.com\/wp-content\/uploads\/sites\/2\/2023\/03\/Billy-Boyle-scaled-e1680865576702.jpg\" alt=\"\" title=\"Billy Boyle\" height=\"600\" width=\"900\" itemprop=\"thumbnailUrl\"><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>If successful, the resulting antigen-targeted EVOC Probes will have the potential for use in pre-clinical research to support both cell-based and <em>in-vivo<\/em> studies; in clinical trials for patient stratification and measurement of target engagement; and as companion diagnostics to identify responders\/non-responders for therapy selection and to measure target engagement over the course of treatment.<\/p>\n<p>Owlstone is developing diagnostic tests in areas of high unmet clinical need including for the early detection of lung cancer, the most common cancer in the world. To support this effort, Owlstone has pioneered the use of EVOC Probes<sup>1<\/sup> in early detection and precision medicine, with the Company\u2019s lead EVOC Probe in clinical trials. This probe utilizes the activity of enzymes expressed within the tumor microenvironment to release a volatile reporter chemical that can be detected on breath when a tumor is present. The combined approach to be explored under the Agreement will exploit Bicycle\u2019s proprietary Bicycle technology to direct binding and accumulation of the probe on tumor cells, following which increased levels of the reporter chemical would be released.<\/p>\n<p><strong>Billy Boyle, co-founder and CEO at Owlstone Medical, said:<\/strong> <em>\u201cWe are committed at Owlstone to transforming diagnostics through the earlier detection of disease through breath, and are always seeking innovative approaches to further enhance the performance of our tests. Through our partnership with Bicycle, we will jointly explore the exciting possibilities of a combined antigen-targeted EVOC approach for a broad range of precision medicine applications, initially for the early detection of lung cancer to support Owlstone\u2019s ongoing work in this area.\u201d<\/em><\/p>\n<p><a href=\"http:\/\/www.owlstonemedical.com\/science-technology\/evoc-probes\/\" target=\"_blank\" rel=\"noopener noreferrer\">www.owlstonemedical.com\/science-technology\/evoc-probes\/<\/a><\/p>\n<\/div><\/section><br \/>\n<div  class='av-social-sharing-box  avia-builder-el-10  el_after_av_textblock  avia-builder-el-last  av-social-sharing-box-minimal '><div class='av-share-box'><h5 class='av-share-link-description av-no-toc '>Share this<\/h5><ul class='av-share-box-list noLightbox'><li class='av-share-link av-social-link-facebook' ><a target=\"_blank\" aria-label=\"Share on Facebook\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https:\/\/clinlabint.com\/owlstone-medical-enters-partnership-with-bicycle-therapeutics-for-the-development-of-antigen-targeted-evoc-probes-for-early-cancer-detection\/&#038;t=Owlstone%20Medical%20Enters%20Partnership%20with%20Bicycle%20Therapeutics%20for%20the%20Development%20of%20Antigen-Targeted%20EVOC%20Probes%20for%20Early%20Cancer%20Detection\" aria-hidden=\"false\" data-av_icon=\"\ue8f3\" data-av_iconfont=\"entypo-fontello\" title=\"\" data-avia-related-tooltip=\"Share on Facebook\" rel=\"noopener\"><span class='avia_hidden_link_text'>Share on Facebook<\/span><\/a><\/li><li class='av-share-link av-social-link-twitter' ><a target=\"_blank\" aria-label=\"Share on Twitter\" href=\"https:\/\/twitter.com\/share?text=Owlstone%20Medical%20Enters%20Partnership%20with%20Bicycle%20Therapeutics%20for%20the%20Development%20of%20Antigen-Targeted%20EVOC%20Probes%20for%20Early%20Cancer%20Detection&#038;url=https:\/\/clinlabint.com\/?p=18994\" aria-hidden=\"false\" data-av_icon=\"\ue8f1\" data-av_iconfont=\"entypo-fontello\" title=\"\" data-avia-related-tooltip=\"Share on Twitter\" rel=\"noopener\"><span class='avia_hidden_link_text'>Share on Twitter<\/span><\/a><\/li><li class='av-share-link av-social-link-whatsapp' ><a target=\"_blank\" aria-label=\"Share on WhatsApp\" href=\"https:\/\/api.whatsapp.com\/send?text=https:\/\/clinlabint.com\/owlstone-medical-enters-partnership-with-bicycle-therapeutics-for-the-development-of-antigen-targeted-evoc-probes-for-early-cancer-detection\/\" aria-hidden=\"false\" data-av_icon=\"\uf232\" data-av_iconfont=\"entypo-fontello\" title=\"\" data-avia-related-tooltip=\"Share on WhatsApp\" rel=\"noopener\"><span class='avia_hidden_link_text'>Share on WhatsApp<\/span><\/a><\/li><li class='av-share-link av-social-link-linkedin' ><a target=\"_blank\" aria-label=\"Share on LinkedIn\" href=\"https:\/\/linkedin.com\/shareArticle?mini=true&#038;title=Owlstone%20Medical%20Enters%20Partnership%20with%20Bicycle%20Therapeutics%20for%20the%20Development%20of%20Antigen-Targeted%20EVOC%20Probes%20for%20Early%20Cancer%20Detection&#038;url=https:\/\/clinlabint.com\/owlstone-medical-enters-partnership-with-bicycle-therapeutics-for-the-development-of-antigen-targeted-evoc-probes-for-early-cancer-detection\/\" aria-hidden=\"false\" data-av_icon=\"\ue8fc\" data-av_iconfont=\"entypo-fontello\" title=\"\" data-avia-related-tooltip=\"Share on LinkedIn\" rel=\"noopener\"><span class='avia_hidden_link_text'>Share on LinkedIn<\/span><\/a><\/li><li class='av-share-link av-social-link-mail' ><a  aria-label=\"Share by Mail\" href='mailto:?subject=Owlstone%20Medical%20Enters%20Partnership%20with%20Bicycle%20Therapeutics%20for%20the%20Development%20of%20Antigen-Targeted%20EVOC%20Probes%20for%20Early%20Cancer%20Detection&#038;body=https:\/\/clinlabint.com\/owlstone-medical-enters-partnership-with-bicycle-therapeutics-for-the-development-of-antigen-targeted-evoc-probes-for-early-cancer-detection\/' aria-hidden='false' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' title='' data-avia-related-tooltip='Share by Mail'><span class='avia_hidden_link_text'>Share by Mail<\/span><\/a><\/li><\/ul><\/div><\/div><\/p><\/div><div class=\"flex_column av_one_fifth  av-hide-on-mobile  flex_column_div av-zero-column-padding   avia-builder-el-11  el_after_av_three_fifth  avia-builder-el-last  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center\"><\/p>\n<\/div><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research will focus on applying Bicycle\u2019s bicyclic peptide technology to Owlstone\u2019s EVOC Probes Antigen-targeted EVOC Probes have potential for use in preclinical research, clinical trials, and as companion diagnostics and tests for early detection of disease Initial research will focus on the early detection of lung cancer<\/p>\n","protected":false},"author":3,"featured_media":18995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-18994","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/18994"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=18994"}],"version-history":[{"count":2,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/18994\/revisions"}],"predecessor-version":[{"id":18999,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/18994\/revisions\/18999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media\/18995"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=18994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=18994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=18994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}