New findings by Columbia researchers suggest that along with amyloid deposits, white matter hyperintensities (WMHs) may be a second necessary factor for the development of Alzheimer\u2019s disease.<\/p>\n
Most current approaches to Alzheimer\u2019s disease focus on the accumulation of amyloid plaque in the brain. The researchers at the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, led by Adam M. Brickman, PhD, assistant professor of neuropsychology, examined the additional contribution of small-vessel cerebrovascular disease, which they visualised as white matter hyperintensities (WMHs).<\/p>\n
The study included 20 subjects with clinically defined Alzheimer\u2019s disease, 59 subjects with mild cognitive impairment, and 21 normal control subjects. Using data from the Alzheimer\u2019s Disease Neuro-imaging Initiative public database, the researchers found that amyloid and WHMs were equally associated with an Alzheimer\u2019s diagnosis. Amyloid and WMHs were also equally predictive of which subjects with mild-cognitive impairment would go on to develop Alzheimer\u2019s. Among those with significant amyloid, WMHs were more prevalent in those with Alzheimer\u2019s than in normal control subjects.
\nBecause the risk factors for WMHs\u2014which are mainly vascular\u2014can be controlled, the findings suggest potential ways to prevent the development of Alzheimer\u2019s in those with amyloid deposits.\nColumbia University Medical Center<\/link>\n","protected":false},"excerpt":{"rendered":"
New findings by Columbia researchers suggest that along with amyloid deposits, white matter hyperintensities (WMHs) may be a second necessary factor for the development of Alzheimer\u2019s disease. Most current approaches to Alzheimer\u2019s disease focus on the accumulation of amyloid plaque in the brain. The researchers at the Taub Institute for Research on Alzheimer\u2019s Disease and […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1927"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=1927"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/1927\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=1927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=1927"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=1927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}