{"id":19567,"date":"2023-05-26T12:16:13","date_gmt":"2023-05-26T12:16:13","guid":{"rendered":"https:\/\/clinlabint.com\/?p=19567"},"modified":"2023-05-26T12:24:37","modified_gmt":"2023-05-26T12:24:37","slug":"thermo-fisher-scientific-unveils-hplc-ion-exchange-columns-for-protein-charge-variant-and-aav-separation-analysis","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/thermo-fisher-scientific-unveils-hplc-ion-exchange-columns-for-protein-charge-variant-and-aav-separation-analysis\/","title":{"rendered":"Thermo Fisher Scientific unveils HPLC Ion Exchange Columns for Protein Charge Variant and AAV Separation Analysis"},"content":{"rendered":"
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\r\n\"Bio-Rad<\/a>\r\n<\/p>\n<\/div><\/section><\/div>

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Thermo Fisher Scientific unveils HPLC Ion Exchange Columns for Protein Charge Variant and AAV Separation Analysis<\/h1>\/ in Product News<\/a> <\/span><\/span><\/header>\n<\/div><\/section>
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Thermo Fisher Scientific unveils HPLC Ion Exchange Columns for Protein Charge Variant and AAV Separation Analysis<\/strong><\/h4>\n

Thermo Fisher Scientific is providing biopharmaceutical research laboratories with a new line of ion exchange columns that deliver superior reproducibility, sensitivity and durability for charge-based analysis of therapeutic proteins and separation of full vs. empty adeno-associated virus (AAV) capsids used for gene therapy.<\/strong><\/h3>\n

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The Thermo Scientific ProPac 3R HPLC column portfolio leverages a novel monodisperse particle platform and state-of-the-art separation power to deliver outstanding lot-to-lot reproducibility and consistent results over the lifecycle of a drug, from research and development to commercialization. The new 3 \u00b5m particle size enables a new level of performance with ultra-high resolution of charge variants, improved peak resolution and faster run times. The portfolio supports strong anionexchange (SAX) and strong cation-exchange (SCX) column chemistries, each with two column lengths (50mm and 100mm) and
\ntwo inner diameters (2mm and 4mm).<\/p>\n

Key applications, include: Biopharmaceutical laboratories performing charge variant analysis of therapeutic proteins, including monoclonal antibodies, and separation of full versus empty AAV capsids used for gene therapy.<\/p>\n

The main features include:
\n\u2022 Compatible with the mobile phases and organic solvents used in biopharmaceutical applications
\n\u2022 Designed with bio-inert materials to reduce secondary interactions
\n\u2022 Improved peak-to-valley resolution of charge variants to increase certainty of quantification of critical quality attributes
\n\u2022 Confidence in the detection and identification of new acidic or basic variants during late-stage development
\n\u2022 High sample-loading capacity
\n\u2022 Analytical flexibility for excellent sensitivity and performance under a broad range of pH, temperature and mobile phase compositions as well as MS capabilities<\/p>\n

For more information, visit: https:\/\/bit.ly\/3Mk0dN4<\/a><\/p>\n

Digital issue: Please click here<\/a> for more information<\/p>\n<\/div><\/section>
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Thermo Fisher Scientific unveils HPLC Ion Exchange Columns for Protein Charge Variant and AAV Separation Analysis<\/div><\/div><\/div>
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