Recently, Dr. Cheryle S\u00e9guin, a musculoskeletal researcher at the Schulich School of Medicine & Dentistry, Western University who studies spinal disc development, made a scientific breakthrough that unintentionally provided the missing link researchers needed to study the genesis of chordoma
\nAfter years of work, Dr. S\u00e9guin and her colleagues succeeded in developing a one-of-a-kind genetically engineered mouse that enables researchers to observe and manipulate an embryonic tissue called the notochord. The notochord is important because during development it gives rise to the intervertebral disc, the degeneration of which is the primary cause of back pain afflicting hundreds of millions of people worldwide. In addition to forming the discs, some notochordal cells get lodged inside the developing vertebrae, and, in about 1 in 5 people, these notochordal cells form small benign tumours inside the spine. Occasionally, these benign notochordal cell tumours turn malignant and become a cancer known as chordoma.
\nLittle is known about what causes notochordal cells to turn into chordoma, but now Dr. S\u00e9guin\u2019s mouse makes it possible to study that transformation. To do so, Dr. S\u00e9guin needs to isolate notochordal cells from her mouse and turn them into a cell line \u2013 a constantly dividing family of cells grown in a petri-dish. Creating a notochordal cell line will give scientists a blank slate upon which to introduce genetic changes to see which cellular pathways are activating causing the cells to become cancerous. This could shed light on the cause of chordoma, and, in turn, could point to potential therapies that address the root cause of chordoma.
\nThe Chordoma Foundation is pleased to award Dr. S\u00e9guin a $25,000 seed grant to support her attempts to develop the world\u2019s first notochordal cell line. This grant was made possible by funds raised through the fourth annual Purple Aster Concert, an annual music event in Calgary, Canada, held in memory of chordoma patient Alison Laird. The concert is organized by Alison\u2019s husband, Ian, and friend, Carolyn Harley. Chordoma Foundation board member, Dr. Ed Les, also of Calgary, matched donations by concertgoers to fully sponsor the grant.\nSchulich School of Medicine & Dentistry<\/link>\n","protected":false},"excerpt":{"rendered":"
Recently, Dr. Cheryle S\u00e9guin, a musculoskeletal researcher at the Schulich School of Medicine & Dentistry, Western University who studies spinal disc development, made a scientific breakthrough that unintentionally provided the missing link researchers needed to study the genesis of chordoma After years of work, Dr. S\u00e9guin and her colleagues succeeded in developing a one-of-a-kind genetically […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-2044","post","type-post","status-publish","format-standard","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/2044"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=2044"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/2044\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=2044"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=2044"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=2044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}