{"id":21173,"date":"2024-03-12T15:30:29","date_gmt":"2024-03-12T15:30:29","guid":{"rendered":"https:\/\/clinlabint.com\/?p=21173"},"modified":"2024-03-12T15:30:29","modified_gmt":"2024-03-12T15:30:29","slug":"pharmakure-announces-epigenetics-collaboration-with-sheffield-hallam-university-to-understand-mechanisms-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/pharmakure-announces-epigenetics-collaboration-with-sheffield-hallam-university-to-understand-mechanisms-of-alzheimers-disease\/","title":{"rendered":"PharmaKure announces epigenetics collaboration with Sheffield Hallam University to understand mechanisms of Alzheimer\u2019s Disease"},"content":{"rendered":"
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PharmaKure announces epigenetics collaboration with Sheffield Hallam University to understand mechanisms of Alzheimer\u2019s Disease<\/h1>\/ in E-News<\/a> <\/span><\/span><\/header>\n<\/div><\/section>
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PharmaKure, a clinical stage pharmaceutical company developing precision medicines for Alzheimer\u2019s Disease (AD) and other neurodegenerative diseases, will collaborate with Sheffield Hallam University in the field of epigenetics. The partnership will focus on \u2018gene-based environmental biomarkers\u2019 \u2013 epigenetic markers \u2013 for calculating risk scores for Alzheimer\u2019s diseases. Together with PharmaKure\u2019s blood-based biomarker, ALZmetrix https:\/\/bitly.ws\/3eZTQ<\/a>, this will increase the power of current Alzheimer\u2019s diagnostics.<\/h3>\n

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The collaborative study between Sheffield Hallam University and Pharmakure aims to gain a better understanding of AD in order to identify those more at risk of developing the disease, so enabling the provision of appropriate interventions much earlier in the disease pathology.<\/p>\n<\/div><\/section>
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Professor Gavin Reynolds, Biomolecular Sciences Research Centre, Sheffield Hallam University, explained: \u201cWe have been working on the relationship of environmental stresses with respect to brain diseases.\u201d Prof. Reynolds has published over 300 papers on the pathology of neurotransmitter systems involved in psychiatric disorders and now focuses on epigenetics effects in neuro diseases. \u201cOur genes are coded in our DNA, but epigenetics looks at how the cell turns genes on and off according to different environmental exposure, such as the aging process, stress, trauma etc. We want to identify abnormal epigenetic changes associated with brain diseases, and these changes may be modifiable with medications.\u201d<\/p>\n

Dr Helene Fachim, Neuroscientist, PharmaKure, commented: \u201cMental health and the environment can both contribute to the development of brain diseases. Influences, such as trauma and chronic stress, can bring about epigenetic changes to DNA that may result in a range of psychiatric and neurological disorders. We are therefore looking for epigenetic factors that are specifically related to Alzheimer\u2019s Disease.<\/p>\n

\u201cWe would like to use these epigenetic approaches for a better understanding of AD, so that we can stratify a person\u2019s risk of developing it. Then, we could act in preventive ways, or administer AD drugs earlier in life when they are more effective.\u201d<\/p>\n

AD is a multifactorial disease, and it is known that environmental factors can make an important contribution to triggering it. The study\u2019s main hypothesis is that there is differential methylation in certain target genes related to AD compared to non-AD controls. If this hypothesis proves to be true, Pharmakure can start the validation of an epigenetic predictive risk score for cognitive impairment and AD.<\/p>\n

\u201cWe are very positive and excited about this new epigenetics collaboration, and we believe that bringing together academia and industry is the best way to achieve our goals. We are looking forward to sharing important results in the near future,\u201d said Dr Farid Khan, CEO, PharmaKure.<\/p>\n<\/div><\/section>
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