{"id":21494,"date":"2024-06-21T14:15:01","date_gmt":"2024-06-21T14:15:01","guid":{"rendered":"https:\/\/clinlabint.com\/?p=21494"},"modified":"2024-06-27T13:06:50","modified_gmt":"2024-06-27T13:06:50","slug":"novel-liquid-biopsy-could-detect-and-monitor-aggressive-small-cell-lung-cancer","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/novel-liquid-biopsy-could-detect-and-monitor-aggressive-small-cell-lung-cancer\/","title":{"rendered":"Novel liquid biopsy could detect and monitor aggressive small cell lung cancer"},"content":{"rendered":"
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Novel liquid biopsy could detect and monitor aggressive small cell lung cancer<\/h1>\/ in E-News<\/a> <\/span><\/span><\/header>\n<\/div><\/section>
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A new lab assay developed by researchers at Fred Hutch Cancer Center in Seattle could make diagnosis and treatment of small-cell lung cancer and non-small cell lung cancer easier.<\/h3>\n

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The liquid biopsy can detect differences between types of lung cancer by examining patterns in cell-free tumour DNA in blood samples. It\u2019s a desirable option for detecting small-cell lung cancer (SCLC) as standard needle biopsies fail due the number of smaller tumours typically present and the variety of tumour subtypes that indicate different treatment pathways.<\/p>\n

\u201cThere is a deep need for blood-based assays that define subtypes in SCLC,\u201d said Fred Hutch SCLC researcher David MacPherson, PhD, who co-led the work with Fred Hutch computational biologist Gavin Ha, PhD. \u201cThis new method is a step towards assays that would allow us to test and monitor disease, detect when it transforms into a different lung cancer type, and identify potential treatment targets even when standard biopsies aren\u2019t an option.\u201d The findings were reported in Science Advances [1].<\/p>\n

Such an assay could help oncologists tailor SCLC treatment when new, targeted strategies reach the clinic, and help them monitor patients for recurrence. In addition, it could detect when a patient\u2019s disease has switched from non-small cell lung cancer (NSCLC) to SCLC, which can occur after cancer cells gain resistance to certain targeted therapy and help guide
\na patient\u2019s prognosis and inform new treatment strategies. Similar assays could also be used to improve clinical trials, helping identify trial candidates or providing researchers with information about why a certain patient may or may not respond to treatment.<\/p>\n

To build the new assay, the research team developed a targeted strategy analyzing pre-clinical mouse models using human tissue in which cell-free tumour DNA was easier to sift out from DNA released by healthy cells. They found that the assay performed well when predicting whether DNA had come from an NSCLC or SCLC tumour, suggesting that their approach
\nhas potential for detecting when a patient\u2019s tumour transforms from NSCLC to SCLC.<\/p>\n

\u201cOur approach demonstrates that a full-featured circulating tumour DNA assay has the potential to classify clinical subtypes driven by transcriptional programs,\u201d said Ha, an associate professor in the Herbold Computational Biology Program at Fred Hutch. \u201cThis approach is especially important for SCLC and other tumours that may not have genetic mutations that can inform treatment decisions. The assay expands the boundaries for potentially using circulating tumour DNA to improve treatment selection and cancer management.\u201d<\/p>\n

Reference:<\/strong><\/em>
\n1. Joseph B. Hiatt et al., Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional regulatory regions. Science Advances.10, eadk2082 (2024). doi: https:\/\/doi.org\/10.1126\/sciadv.adk2082<\/a><\/em><\/p>\n<\/div><\/section>
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