{"id":4241,"date":"2020-08-26T09:19:22","date_gmt":"2020-08-26T09:19:22","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/new-generation-alzheimers-diagnostics\/"},"modified":"2021-01-08T11:28:25","modified_gmt":"2021-01-08T11:28:25","slug":"new-generation-alzheimers-diagnostics","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/new-generation-alzheimers-diagnostics\/","title":{"rendered":"New generation Alzheimer\u2019s diagnostics"},"content":{"rendered":"<p>A new generation of ELISAs provides standardized, automated analysis of beta-amyloid (A\u00df) peptides (A\u00df 1-42 and A\u00df 1-40) and total tau (T-tau) proteins in cerebrospinal fl uid (CSF), facilitating diagnosis of Alzheimer\u2019s disease in its early stages. The concentrations of these biomarkers reflect the Alzheimer\u2019s-specific neuropathological changes in the brain. A significant decrease in A\u00df 1-42 is observed as many as 5 to 10 years before the start of cognitive changes. A\u00df 1-40 remains unchanged. The determination of the ratio A\u00df 1-42 to A\u00df 1-40 increases the efficiency of early diagnostics and might help to discriminate Alzheimer\u2019s disease from vascular dementia. The concentrations of T-tau and phosphorylated tau (P-tau) increase when patients develop advanced neurodegeneration and cognitive impairment. Th e A\u00df 1-42, A\u00df 1-40 and T-tau ELISAs have been developed by Euroimmun in collaboration with ADx Neurosciences. They are based on a sandwich principle employing well-characterized capture antibodies. This matrix-independent methodology ensures extremely high consistency in results. The assays are CE-certified and include lyophilized calibrators for added convenience and precision. The procedures are highly standardized and can be automated on Euroimmun analysers and other open ELISA platforms.<br \/>\n<!--more--><br \/>\n<strong>Supplier:<\/strong> EUROIMMUN AG<br \/>\n<strong>Website:<\/strong> <a href=\"\" target=\"_blank\" rel=\"noopener noreferrer\"><\/a><\/p>\n<p><a class=\"avia-button avia-color-theme-color\" href=\"mailto:j.gosink@euroimmun.de\">Mail the supplier<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new generation of ELISAs provides standardized, automated analysis of beta-amyloid (A\u00df) peptides (A\u00df 1-42 and A\u00df 1-40) and total tau (T-tau) proteins in cerebrospinal fl uid (CSF), facilitating diagnosis of Alzheimer\u2019s disease in its early stages. The concentrations of these biomarkers reflect the Alzheimer\u2019s-specific neuropathological changes in the brain. A significant decrease in A\u00df [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":10662,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[39],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/4241"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=4241"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/4241\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media\/10662"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=4241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=4241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=4241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}