{"id":649,"date":"2020-08-26T09:31:37","date_gmt":"2020-08-26T09:31:37","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/concarlo-awarded-patent-for-novel-therapeutic-peptide-for-drug-resistant-breast-cancer\/"},"modified":"2021-01-08T11:07:46","modified_gmt":"2021-01-08T11:07:46","slug":"concarlo-awarded-patent-for-novel-therapeutic-peptide-for-drug-resistant-breast-cancer","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/concarlo-awarded-patent-for-novel-therapeutic-peptide-for-drug-resistant-breast-cancer\/","title":{"rendered":"Concarlo awarded patent for novel therapeutic peptide for drug-resistant breast cancer"},"content":{"rendered":"

Concarlo Holdings has received a US patent for IpY, a novel therapeutic peptide that addresses drug-resistant breast cancer by targeting a unique cellular pathway \u2014 p27Kip1. The patent is the latest step in Concarlo\u2019s journey to commercialize revolutionary medicines for metastatic breast cancer.
\nConcarlo has also announced that a new provisional patent application has been filed for modified versions of the therapeutic peptide that are believed to exhibit enhanced bioavailability. Concarlo is a Brooklyn, New York-based biotechnology innovator dedicated to developing sophisticated, targeted therapies and diagnostics in the oncology space. The IpY technology is the first to address the high incidence of drug-refractory disease that develops with currently available CDK4 inhibitor (CDK4i) treatments. Such a solution has the potential to drastically increase overall survival of breast cancer patients.
\nThe recent introduction of CDK4i drugs, a class of medicines that directly targets the CDK4\/6 pathway implicated in many malignancies, has had a significant impact on the way in which metastatic breast cancer is managed. However, such therapeutics are associated with patients transitioning to a treatment-resistant form of the condition, despite initial extended periods of remission. Backed by more than 20 years of research and development expertise, Concarlo has developed IpY and a companion diagnostic, ApY, to effectively overcome the issue of CDK4i resistance and roll out a more targeted treatment approach for optimized patient outcomes.
\n\u201cDespite the clinical efficacy of CDK4 inhibitors, we\u2019re seeing that primary or secondary resistance to therapy is presenting a significant challenge to overall survival,\u201d said Dr. Dominique Bridon, Chief Development Officer at Concarlo. \u201cWith the IpY technology and its unique mechanism of action, we\u2019re effectively targeting CDK4 while simultaneously inhibiting another target \u2014 CDK2 \u2014 which has been found to be a key molecular player in the development of drug resistance. In doing so, we are the first company to successfully address the CDK4i resistance issue to provide long-term durable tumour arrest. Combined with its highly specific targeting and low toxicity profile, the positive impact of this drug on the breast cancer treatment landscape is hard to understate.\u201d
\nConcarlo was formed in 2016 and is supported by a team of internationally renowned experts forming its Scientific Advisory Board. To date, the company has raised more than $3.1 million to support the development, improvement, and commercialization of its IpY and ApY technologies to bring a precision medicine approach to breast cancer management. The newly issued patent for IpY and the provisional patent application for modified versions of the peptide are the first key milestones in Concarlo\u2019s plan to build an extensive patent estate to maintain market exclusivity for its clinically relevant therapeutics.<\/p>\n","protected":false},"excerpt":{"rendered":"

Concarlo Holdings has received a US patent for IpY, a novel therapeutic peptide that addresses drug-resistant breast cancer by targeting a unique cellular pathway \u2014 p27Kip1. The patent is the latest step in Concarlo\u2019s journey to commercialize revolutionary medicines for metastatic breast cancer. Concarlo has also announced that a new provisional patent application has been […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/649"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=649"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/649\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}