{"id":750,"date":"2020-08-26T09:31:58","date_gmt":"2020-08-26T09:31:58","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/study-indicates-causal-link-between-obesity-and-multiple-diseases\/"},"modified":"2021-01-08T11:08:12","modified_gmt":"2021-01-08T11:08:12","slug":"study-indicates-causal-link-between-obesity-and-multiple-diseases","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/study-indicates-causal-link-between-obesity-and-multiple-diseases\/","title":{"rendered":"Study indicates causal link between obesity and multiple diseases"},"content":{"rendered":"<p><span lang=\"EN-GB\">A new study, led by Professor Elina Hypp\u00f6nen from UniSA\u2019s Australian Centre for Precision Health, presents the strongest evidence yet of a causal relationship between obesity and a wide range of serious conditions, including cardiovascular disease, diabetes, cancer, and neurological, musculoskeletal and respiratory afflictions.<\/span><br \/>\n<span lang=\"EN-GB\">The study draws data from the UK Biobank \u2013 a research database holding health and genetic information from half a million volunteers \u2013 to analyse associations between body mass index (BMI) and a range of disease outcomes in 337,536 people.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cIn this study we used a genetic approach to seek evidence for true health effects associated with higher body mass index, which assesses our weight against our height and is commonly used to measure obesity,\u201d Prof Hypp\u00f6nen says.<\/span><br \/>\n<span lang=\"EN-GB\">Previous research has suggested that high BMI is associated with increased risk of chronic diseases such as type 2 diabetes, cardiovascular disease and cancer, but due to the difficulty of conducting clinical trials related to obesity, it has been hard to prove causation.<\/span><br \/>\n<span lang=\"EN-GB\">Prof Hypp\u00f6nen and her team developed a multi-dimensional analysis in which genetic data was subjected to a suite of stringent examinations in order to deliver high confidence of causality.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cWe compared evidence from five different statistical approaches to establish how strong the evidence for causal effect actually is,\u201d she says.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cFully consistent evidence across all approaches was seen for 14 different diseases, and for 26 different diseases evidence was obtained by at least for four of the five methods used.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cWhat increases the confidence that these associations are largely reflective of real effects is the fact that those effects which came across with consistent evidence are also ones for which we have previous clinical evidence.\u201d<\/span><br \/>\n<span lang=\"EN-GB\">One key finding from the study was the extent to which it confirms existing concerns over the link between obesity and diabetes, with many of the diseases identified as related to high BMI known to be commonly associated with poorly controlled diabetes.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cFor example, we saw evidence for effects on peripheral nerve disorders, chronic leg and foot ulcers, and even gangrene and kidney failure, which are all known to be diabetic complications. This suggests a key aspect to reduce comorbidity risk in obesity is careful monitoring of blood sugar and effective control of diabetes and its complications,\u201d Prof Hypp\u00f6nen says.<\/span><br \/>\n<span lang=\"EN-GB\">The study also highlights the importance of genetic research to further our understanding of the role genes play in obesity, and the insights it can provide for the future management and treatment of obesity.<\/span><br \/>\n<span lang=\"EN-GB\">University of South Australia<\/span>\n<link https:\/\/tinyurl.com\/yxmrpkm5><span lang=\"EN-GB\">https:\/\/tinyurl.com\/yxmrpkm5<\/span><\/link>\n","protected":false},"excerpt":{"rendered":"<p>A new study, led by Professor Elina Hypp\u00f6nen from UniSA\u2019s Australian Centre for Precision Health, presents the strongest evidence yet of a causal relationship between obesity and a wide range of serious conditions, including cardiovascular disease, diabetes, cancer, and neurological, musculoskeletal and respiratory afflictions. The study draws data from the UK Biobank \u2013 a research [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/750"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=750"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/750\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}