{"id":840,"date":"2020-08-26T09:31:58","date_gmt":"2020-08-26T09:31:58","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/depleted-metabolic-enzymes-promote-tumour-growth-in-kidney-cancer\/"},"modified":"2021-01-08T11:08:36","modified_gmt":"2021-01-08T11:08:36","slug":"depleted-metabolic-enzymes-promote-tumour-growth-in-kidney-cancer","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/depleted-metabolic-enzymes-promote-tumour-growth-in-kidney-cancer\/","title":{"rendered":"Depleted metabolic enzymes promote tumour growth in kidney cancer"},"content":{"rendered":"<p><span lang=\"EN-GB\">Kidney cancer, one of the ten most prevalent malignancies in the world, has increased in incidence over the last decade, likely due to rising obesity rates. The most common subtype of this cancer is \u201cclear cell\u201d renal cell carcinoma (ccRCC), which exhibits multiple metabolic abnormalities, such as highly elevated stored sugar and fat deposition.<\/span><br \/>\n<span lang=\"EN-GB\">By integrating data on the function of essential metabolic enzymes with genetic, protein, and metabolic abnormalities associated with ccRCC, researchers at the Perelman School of Medicine at the University of Pennsylvania determined that enzymes important in multiple pathways are universally depleted in ccRCC tumors. <\/span><br \/>\n<span lang=\"EN-GB\">\u201cKidney cancer develops from an extremely complex set of cellular malfunctions,\u201d said senior author Celeste Simon, PhD, the scientific director of the Abramson Family Cancer Research Institute and a professor of Cell and Developmental Biology. \u201cThat\u2019s why we approached studying its cause from many perspectives.\u201d<\/span><br \/>\n<span lang=\"EN-GB\">Using human tissue provided by the National Cancer Institute\u2019s Cooperative Human Tissue Network and Penn Medicine physicians Naomi Haas, MD, an associate professor of Hematology\/Oncology, and Priti Lal, MD, an associate professor of Pathology and Laboratory Medicine, the team found that the expression of certain enzymes is strongly repressed in ccRCC tumors. For example, reduced activity of one enzyme, arginase, promotes ccRCC tumour growth through at least two distinct biochemical pathways. One is by conserving a critical molecular cofactor and the second is by avoiding toxic accumulation of organic compounds. The enzymes whose activities are depressed are involved in the breakdown of urea, a by-product of protein being used in the human body. In addition, loss of these enzymes results in decreased ability of the immune system to eradicate these tumours.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cPharmacological approaches to restore the expression of urea cycle enzymes would greatly expand treatment options for ccRCC patients, whose current therapies only benefit a small subset,\u201d Simon said. <\/span><\/p>\n<p>Penn Medicine<br \/><span lang=\"EN-GB\"><link https:\/\/www.pennmedicine.org\/news\/news-releases\/2018\/may\/depleted-metabolic-enzymes-promote-tumor-growth-in-kidney-cancer-1 _blank external-link-new-window \"Opens external link in new window\">www.pennmedicine.org\/news\/news-releases\/2018\/may\/depleted-metabolic-enzymes-promote-tumor-growth-in-kidney-cancer-1<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kidney cancer, one of the ten most prevalent malignancies in the world, has increased in incidence over the last decade, likely due to rising obesity rates. The most common subtype of this cancer is \u201cclear cell\u201d renal cell carcinoma (ccRCC), which exhibits multiple metabolic abnormalities, such as highly elevated stored sugar and fat deposition. By [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-840","post","type-post","status-publish","format-standard","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/840"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=840"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/840\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}