In a new study researchers from the Institute for Experimental Pediatric Endocrinology of the Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin have successfully treated patients whose obesity is caused by a genetic defect. Aside from its beneficial effects on the patients, the researchers also provided insights into the fundamental signalling pathways regulating satiety of the new drug.
\nA mutation in the gene encoding the leptin receptor (LEPR) can cause extreme hunger starting with the first months of life. As a result, affected individuals develop extreme obesity during childhood. Increased exercise and reduced caloric intake are usually insufficient to stabilize body-weight. In many cases, obesity surgery fails to deliver any benefits, meaning that a drug-based treatment approach becomes increasingly important.
\nTwo years ago, Dr. Peter K\u00fchnen and the working group successfully demonstrated that treatment with a peptide, which activates the melanocortin 4 receptor (MC4R) could play a central role in the body\u2019s energy metabolism and body weight regulation. Leptin, which is also known as the satiety (or starvation) hormone, normally binds to the LEPR, triggering a series of steps that leads to the production of melanocytestimulating hormone (MSH). The binding of MSH to its receptor, the melanocortin 4 receptor (MC4R) transduces the satiety signal to the body. However, if LEPR is defective, the signalling cascade is interrupted. The patient\u2019s hunger remains unabated, placing her\/him at greater risk of becoming obese. As part of this current study, researchers used a peptide that binds to the MC4R in the brain, and this activation triggers the normal satiety signal. Working in cooperation with the Clinical Research Unit at the Berlin Institute of Health (BIH), the researchers were able to record significant weight loss in patients with genetic defects affecting LEPR.
\n\u201cWe also wanted to determine why the used peptide was so effective and why, in contrast to other preparations with a similar mode of action, it did not produce any severe side effects,\u201d explains Dr. K\u00fchnen. \u201cWe were able to demonstrate that this treatment leads to the activation of a specific and important signalling pathway, whose significance had previously been underestimated.\u201d Dr. K\u00fchnen\u2019s team is planning to conduct further research to determine whether other patients might benefit from this drug: \u201cIt is possible that other groups of patients with dysfunctions affecting the same signalling pathway might be suitable candidates for this treatment.\u201d<\/p>\n
Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin https:\/\/tinyurl.com\/y7dyaqm4<\/link>\n","protected":false},"excerpt":{"rendered":"
In a new study researchers from the Institute for Experimental Pediatric Endocrinology of the Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin have successfully treated patients whose obesity is caused by a genetic defect. Aside from its beneficial effects on the patients, the researchers also provided insights into the fundamental signalling pathways regulating satiety of the new drug. A […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/858"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=858"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/858\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}