{"id":891,"date":"2020-08-26T09:32:18","date_gmt":"2020-08-26T09:32:18","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/proteins-reveal-new-mechanisms-in-prostate-cancer\/"},"modified":"2021-01-08T11:08:47","modified_gmt":"2021-01-08T11:08:47","slug":"proteins-reveal-new-mechanisms-in-prostate-cancer","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/proteins-reveal-new-mechanisms-in-prostate-cancer\/","title":{"rendered":"Proteins reveal new mechanisms in prostate cancer"},"content":{"rendered":"<p><span lang=\"EN-GB\">A study by the University of Tampere in Finland used protein profiling to find new prostate cancer mechanisms that are not shown by aberrations at the genomic level. Several new potential biomarkers of prostate cancer were also found.<\/span><br \/>\n<span lang=\"EN-GB\">Genes that affect prostate cancer evolution have been studied for a long time. However, changes in the protein levels are not well known.<\/span><br \/>\n<span lang=\"EN-GB\">The Center for Prostate Cancer Research and the Center for Proteomics and Personalized Medicine at the University of Tampere cooperated to profile the protein expression of prostate cancer by using mass spectrometry for the first time. The researchers compared protein expression to genomic and messenger RNAs in the same samples.<\/span><br \/>\n<span lang=\"EN-GB\">The result was that the changes in gene copy numbers and DNA methylation largely explain messenger RNA expression but not the changes on the protein level. The association between messenger RNA expression and protein levels was also weak. The study thus uncovered such mechanisms of prostate cancer that are not indicated by the alterations at the genomic level.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cIn particular, changes in the citric acid cycle emerged in our analyses,\u201d Adjunct Professor Leena Latonen says.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cThe results enable exploring the significance of these changes,&quot; Latonen continues.<\/span><br \/>\n<span lang=\"EN-GB\">In addition to the disease mechanisms, protein profiling revealed several potential new biomarkers.<\/span><br \/>\n<span lang=\"EN-GB\">According to Professor Tapio Visakorpi, biomarkers able to recognize the aggressive forms of prostate cancer would be especially useful. That is one of the aspects on which the researchers will focus next.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cDiscovering these protein biomarkers was enabled by the long-term interdisciplinary work of the research groups on the Kauppi campus of the University of Tampere,\u201d says Professor Hannu Uusitalo, Director of the Center for Proteomics and Personalized Medicine.<\/span><br \/>\n<span lang=\"EN-GB\">University of Tampere<link https:\/\/www.uta.fi\/en\/news\/story\/proteins-reveal-new-mechanisms-prostate-cancer _blank external-link-new-window \"Opens external link in new window\">www.uta.fi\/en\/news\/story\/proteins-reveal-new-mechanisms-prostate-cancer<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study by the University of Tampere in Finland used protein profiling to find new prostate cancer mechanisms that are not shown by aberrations at the genomic level. Several new potential biomarkers of prostate cancer were also found. Genes that affect prostate cancer evolution have been studied for a long time. However, changes in the [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/891"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=891"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/891\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=891"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=891"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}