{"id":904,"date":"2020-08-26T09:32:18","date_gmt":"2020-08-26T09:32:18","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/medical-researchers-find-protein-that-marks-difference-between-cancer-and-non-cancer-cells\/"},"modified":"2021-01-08T11:08:49","modified_gmt":"2021-01-08T11:08:49","slug":"medical-researchers-find-protein-that-marks-difference-between-cancer-and-non-cancer-cells","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/medical-researchers-find-protein-that-marks-difference-between-cancer-and-non-cancer-cells\/","title":{"rendered":"Medical researchers find protein that marks difference between cancer and non-cancer cells"},"content":{"rendered":"<p><span lang=\"EN-GB\">A discovery sheds light on how cancerous cells differ from healthy ones, and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers in the future.<\/span><br \/>\n<span lang=\"EN-GB\">An international team of investigators found a \u201cstop sign\u201d\u2014a modified protein researchers named a PIP-stop\u2014inside cells that are overused by cancerous cells that effectively prevents healthy ones from sorting material in the way they were designed to.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cWe have discovered that breast cancer, leukaemia, lymphoma and neuroblastoma cells have too many PIP-stops. This would upset protein function, and opens up a new avenue for developing drugs that block PIP-stop formation by kinase enzymes,\u201d said Michael Overduin, a University of Alberta cancer researcher and professor of biochemistry, who led the research project.<\/span><br \/>\n<span lang=\"EN-GB\">The team named the modification a PIP-stop because it stops proteins from interacting with lipid molecules called PIP.<\/span><br \/>\n<span lang=\"EN-GB\">Before making their discovery, the researchers first solved the 3-D structure of a sorting nexin protein, which is key to sorting proteins to their proper locations within the cell. Powerful magnets in the U.K. and in the National High Field Nuclear Magnetic Resonance Centre (NANUC), Canada\u2019s national magnet lab based in Edmonton, were then used to detect signals from within individual atoms within the protein structure.<\/span><br \/>\n<span lang=\"EN-GB\">By focusing on the protein structure, the team was able to discover the PIP-stop and see how it blocked the protein\u2019s function. The PIP-stop is a phosphate which is added to the protein surface that binds the PIP lipid, and normally controls how proteins attach to membranes.<\/span><br \/>\n<span lang=\"EN-GB\">Samples from cancer patients have too many PIP-stops, which could lead to the unregulated growth seen in tumour cells. Similar PIP-stops were found to be overused in a large number of other proteins involved in other cancer types, where they could also influence tumour growth.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cOur goal now is to design inhibitors for the overactive kinases that create PIP-stops, and to use this information to design drug molecules that block the progression of cancers, particularly those which lack effective treatments,\u201d said Overduin.<\/span><br \/>\n<span lang=\"EN-GB\">University of Alberta Faculty of Medicine &amp; Dentistry<link https:\/\/www.folio.ca\/medical-researchers-find-protein-that-marks-difference-between-cancer-and-non-cancer-cells\/ _blank external-link-new-window \"Opens external link in new window\">www.folio.ca\/medical-researchers-find-protein-that-marks-difference-between-cancer-and-non-cancer-cells\/<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A discovery sheds light on how cancerous cells differ from healthy ones, and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers in the future. An international team of investigators found a \u201cstop sign\u201d\u2014a modified protein researchers named a PIP-stop\u2014inside cells that are overused by cancerous cells that effectively prevents [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/904"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=904"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/904\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}