{"id":939,"date":"2020-08-26T09:32:18","date_gmt":"2020-08-26T09:32:18","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/genetic-link-found-between-the-immune-system-and-lymphoma\/"},"modified":"2021-01-08T11:08:59","modified_gmt":"2021-01-08T11:08:59","slug":"genetic-link-found-between-the-immune-system-and-lymphoma","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/genetic-link-found-between-the-immune-system-and-lymphoma\/","title":{"rendered":"Genetic link found between the immune system and lymphoma"},"content":{"rendered":"

People who inherit genetic changes which alter the function of their immune system are at increased risk of developing Hodgkin lymphoma, a major new study reports.<\/span>
\nScientists at The Institute of Cancer Research, London, identified six new genetic changes that increase the risk of developing Hodgkin lymphoma \u2013 one of the most common cancers in young adults.<\/span>
\nMany of the DNA changes seemed to affect the function of the immune system, and three had previously been associated with autoimmune diseases such as multiple sclerosis, rheumatoid arthritis or lupus.<\/span>
\nThe researchers stressed that the link did not mean people with autoimmune diseases are at increased risk of lymphoma, but did offer important genetic clues for understanding both lymphoma and autoimmune diseases better.<\/span>
\nOne of the genetic changes discovered increases the risk of Hodgkin lymphoma by more than a third and others by at least 15% each \u2013 information that could point to new targeted drugs for the disease.<\/span>
\nResearch at the ICR is underpinned by generous contributions from our supporters. Find out more about how you can contribute to our mission to make the discoveries to defeat cancer. <\/span>
\nScientists at the ICR analysed genetic data from 5,314 cases of Hodgkin lymphoma and 16,749 controls, from four different European studies.<\/span>
\nThe study is the largest of its kind for Hodgkin lymphoma.<\/span>
\nFor most people, Hodgkin lymphoma can be successfully treated with first-line therapies \u2013 but there is a need for new treatments for those for whom first line treatment has failed.<\/span>
\nThe researchers identified six new single-letter changes in DNA that were linked to the development of Hodgkin lymphoma \u2013 and five of these affect the way a type of white blood cell, called B cells, develop.<\/span>
\nHodgkin lymphoma is a cancer of the B cells \u2013 which are responsible for producing antibodies as a critical component of the immune system.<\/span>
\nThe study also picked out clear differences in genetic risk between two different subtypes of Hodgkin Lymphoma \u2013 nodular sclerosis Hodgkin Lymphoma (NSHL) and mixed cellularity Hodgkin Lymphoma (MCHL).<\/span>
\nFor example, a single-letter change located in DNA near the gene LPP increased the risk of NSHL by 37%, but had little effect on the risk of developing MCHL.<\/span>
\nProfessor Richard Houlston, Professor of Molecular and Population Genetics at the ICR, said: \u201cHodgkin lymphoma is a cancer of immune cells called B cells, and our study links the risk of the disease to changes in the genes that control how B cells develop. Interestingly, we found that some of the genetic changes we have linked to Hodgkin lymphoma have previously been associated with the risk of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.<\/span>
\n\u201cIt doesn\u2019t mean that if you develop an autoimmune disease you are at increased risk of lymphoma, but it does offer fascinating genetic clues to these diseases. The new information could point towards new ways of diagnosing, treating, or even helping to prevent Hodgkin lymphoma.\u201d<\/span>
\nInstitute of Cancer Research<\/span>
\nwww.icr.ac.uk\/news-archive\/genetic-link-found-between-the-immune-system-and-lymphoma<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

People who inherit genetic changes which alter the function of their immune system are at increased risk of developing Hodgkin lymphoma, a major new study reports. Scientists at The Institute of Cancer Research, London, identified six new genetic changes that increase the risk of developing Hodgkin lymphoma \u2013 one of the most common cancers in […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/939"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=939"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/939\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}