{"id":941,"date":"2020-08-26T09:32:18","date_gmt":"2020-08-26T09:32:18","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/sperm-rna-may-serve-as-biomarkers-of-future-health\/"},"modified":"2021-01-08T11:09:00","modified_gmt":"2021-01-08T11:09:00","slug":"sperm-rna-may-serve-as-biomarkers-of-future-health","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/sperm-rna-may-serve-as-biomarkers-of-future-health\/","title":{"rendered":"Sperm RNA may serve as biomarkers of future health"},"content":{"rendered":"<p><span lang=\"EN-GB\">Human sperm may hold the potential to serve as biomarkers of the future health of newborn infants, according to a new study by a Wayne State University School of Medicine research team.<\/span><br \/>\n<span lang=\"EN-GB\">The study, \u201cSperm RNA elements as markers of health,\u201d from the lab of Stephen Krawetz, Ph.D., the Charlotte B. Failing Professor of Fetal Therapy and Diagnosis in the WSU Department of Obstetrics and Gynecology and Center for Molecular Medicine and Genetics, indicates that RNA found in male sperm not only shows promise as a determinant in successful live birth, it may also tell us more about the health of a child as it matures.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cWe explored the opportunity of using sperm RNA elements as a predictor of human health, with applications at the fertility clinic that would go hand-in-hand with the new neonatal intensive care unit genome sequencing to better health outcomes,\u201d said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and Development. \u201cThis leaves the intriguing possibility that, while sperm RNAs delivered to the egg inform the success of live birth, they may also open a pathway to understanding the birth and potential health of each child.<\/span><br \/>\n<span lang=\"EN-GB\">At fertilization, sperm delivers a structurally distinct genome, along with a complement of ribonucleic acids, or RNAs, and proteins to the immature egg cell. To test the hypothesis, sperm RNA elements corresponding to specific genes were characterized as a function of disease association. Dr. Krawetz\u2019s team surveyed a total of 278,605 sperm RNA elements called short exon-sized sequences, or SREs, associated with diseases. This functional association of SREs may indicate a future phenotype, providing improved understanding of the father\u2019s contribution to the life course of the child as well as the current state of paternal health.<\/span><br \/>\n<span lang=\"EN-GB\">In the future, if those SREs that are mutated or modified can be identified, researchers and physicians may be able to not only forecast disease or conditions, but develop ways to prevent them.<\/span><br \/>\n<span lang=\"EN-GB\">Wayne State University<\/span><br \/>\n<span lang=\"EN-GB\"><link https:\/\/www.med.wayne.edu\/news\/2017\/12\/01\/sperm-rna-may-serve-as-biomarkers-of-future-health-wsu-researchers-find\/ _blank external-link-new-window \"Opens external link in new window\">www.med.wayne.edu\/news\/2017\/12\/01\/sperm-rna-may-serve-as-biomarkers-of-future-health-wsu-researchers-find\/<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Human sperm may hold the potential to serve as biomarkers of the future health of newborn infants, according to a new study by a Wayne State University School of Medicine research team. The study, \u201cSperm RNA elements as markers of health,\u201d from the lab of Stephen Krawetz, Ph.D., the Charlotte B. Failing Professor of Fetal [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-941","post","type-post","status-publish","format-standard","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/941"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=941"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/941\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}