{"id":950,"date":"2020-08-26T09:32:39","date_gmt":"2020-08-26T09:32:39","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/genetic-testing-can-help-determine-safest-dose-of-warfarin-for-joint-surgery-patients\/"},"modified":"2021-01-08T11:09:02","modified_gmt":"2021-01-08T11:09:02","slug":"genetic-testing-can-help-determine-safest-dose-of-warfarin-for-joint-surgery-patients","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/genetic-testing-can-help-determine-safest-dose-of-warfarin-for-joint-surgery-patients\/","title":{"rendered":"Genetic testing can help determine safest dose of warfarin for joint surgery patients"},"content":{"rendered":"<p><span lang=\"EN-GB\">A new five-year study of nearly 1,600 patients finds that genetic testing can help determine the safest dose of the blood thinner warfarin, with fewer side effects, in patients undergoing joint replacement surgery.<\/span><br \/>\n<span lang=\"EN-GB\">Considering a patient\u2019s genetic makeup when prescribing warfarin\u2014a blood thinner commonly prescribed to prevent life-threatening blood clots\u2014can mean fewer adverse side effects like haemorrhage, researchers found.<\/span><br \/>\n<span lang=\"EN-GB\">Warfarin is a commonly prescribed, very effective anticlotting medicine \u2014 but it\u2019s often associated with adverse complications and each patient requires a different dosage to achieve the desired treatment effect.<\/span><br \/>\n<span lang=\"EN-GB\">That unique dosing is based in part on an individual\u2019s genetics, and great interest exists in understanding whether an individual\u2019s genetics can guide how to best prescribe warfarin to reach the optimal therapeutic range.<\/span><br \/>\n<span lang=\"EN-GB\">Now, researchers from Intermountain Medical Center, along with four other research centers, including Washington University School of Medicine in St. Louis, which led the national study, have shown that outcomes greatly improve for older patients who undergo elective hip or knee replacement when the dose of warfarin is based on how a patient\u2019s liver metabolizes the blood thinner, which can be discovered using a blood test.<\/span><br \/>\n<span lang=\"EN-GB\">Researchers say study findings from the GIFT study (Genetics Informatics Trial of Warfarin to Prevent Deep Venous Thrombosis) are significant. Compared to patients who received a standard dose, patients who received genetically-dosed warfarin had a 27 percent reduction in complications.<\/span><br \/>\n<span lang=\"EN-GB\">Specifically, their major bleeding was reduced by 75 percent, the incidence of excessive international normalized ratios was reduced by about 30 percent, and blood clots occurred 15 percent less often. No patients died during the study.<\/span><br \/>\n<span lang=\"EN-GB\">The findings from the GIFT study are published and could be used immediately. The Food and Drug Administration has since 2007 included language in its warfarin packaging that encourages the use of genetic guidance, if it\u2019s available.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cDifferences can be identified by looking at a patient\u2019s genetic makeup, and specifically at the genes that are responsible for the liver\u2019s metabolism of the drug,\u201d said Scott Woller, MD, co-director of the Thrombosis Program at Intermountain Medical Center and principal investigator for Intermountain Healthcare.<\/p>\n<p><\/span><br \/>\n<span lang=\"EN-GB\">Intermountain Healthcare<\/span><br \/>\n<span lang=\"EN-GB\"><link https:\/\/intermountainhealthcare.org\/news\/2017\/10\/genetic-testing-can-help-determine-safest-dose-of-warfarin-for-joint-surgery-patients\/ _blank external-link-new-window \"Opens external link in new window\">intermountainhealthcare.org\/news\/2017\/10\/genetic-testing-can-help-determine-safest-dose-of-warfarin-for-joint-surgery-patients\/<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new five-year study of nearly 1,600 patients finds that genetic testing can help determine the safest dose of the blood thinner warfarin, with fewer side effects, in patients undergoing joint replacement surgery. Considering a patient\u2019s genetic makeup when prescribing warfarin\u2014a blood thinner commonly prescribed to prevent life-threatening blood clots\u2014can mean fewer adverse side effects [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-950","post","type-post","status-publish","format-standard","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/950"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=950"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/950\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=950"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}