{"id":962,"date":"2020-08-26T09:32:39","date_gmt":"2020-08-26T09:32:39","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/gene-that-influences-nicotine-dependence-identified\/"},"modified":"2021-01-08T11:09:05","modified_gmt":"2021-01-08T11:09:05","slug":"gene-that-influences-nicotine-dependence-identified","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/gene-that-influences-nicotine-dependence-identified\/","title":{"rendered":"Gene that influences nicotine dependence identified"},"content":{"rendered":"<p><span lang=\"EN-GB\">A DNA variant\u2014located in the DNMT3B gene and commonly found in people of European and African descent\u2014increases the likelihood of developing nicotine dependence, smoking heavily, and developing lung cancer, according to a new study led by RTI International.<\/span><br \/>\n<span lang=\"EN-GB\">Nearly 1 billion people smoke and 6 million premature deaths occur worldwide each year from cigarette smoking, according to the World Health Organization. Smoking is the leading cause of preventable death and one person dies approximately every 6 seconds from smoking-related causes, according to the WHO.<\/span><br \/>\n<span lang=\"EN-GB\">The new study is the largest genome-wide association study of nicotine dependence. Researchers studied more than 38,600 former and current smokers from the United States, Iceland, Finland, and the Netherlands. <\/span><br \/>\n<span lang=\"EN-GB\">\u201cThis new finding widens the scope of how genetic factors are known to influence nicotine dependence,\u201d said Dana Hancock, Ph.D., genetic epidemiologist at RTI and lead author of the study. \u201cThe variant that we identified is common, occurring in 44 percent of Europeans or European Americans and 77 percent of African Americans, and it exerts important effects on gene regulation in human brain, specifically in the cerebellum, which has long been overlooked in the study of addiction.\u201d<\/span><br \/>\n<span lang=\"EN-GB\">The genetic variant was linked to an increased risk of nicotine dependence by testing nearly 18 million variants across the genome for association with nicotine dependence. The variant was also tested in independent studies and found to associate with heavier smoking and with increased risk of lung cancer.&nbsp; <\/span><\/p>\n<p><span lang=\"EN-GB\">RTI International<\/span><br \/>\n<span lang=\"EN-GB\"><link https:\/\/www.rti.org\/news\/researchers-identify-gene-influences-nicotine-dependence _blank external-link-new-window \"Opens external link in new window\">www.rti.org\/news\/researchers-identify-gene-influences-nicotine-dependence<\/link><\/span><br \/>\n<span lang=\"EN-GB\">&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A DNA variant\u2014located in the DNMT3B gene and commonly found in people of European and African descent\u2014increases the likelihood of developing nicotine dependence, smoking heavily, and developing lung cancer, according to a new study led by RTI International. Nearly 1 billion people smoke and 6 million premature deaths occur worldwide each year from cigarette smoking, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/962"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=962"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/962\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}