{"id":964,"date":"2020-08-26T09:32:39","date_gmt":"2020-08-26T09:32:39","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/genetic-drivers-of-most-common-form-of-lymphoma-identified\/"},"modified":"2021-01-08T11:09:05","modified_gmt":"2021-01-08T11:09:05","slug":"genetic-drivers-of-most-common-form-of-lymphoma-identified","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/genetic-drivers-of-most-common-form-of-lymphoma-identified\/","title":{"rendered":"Genetic drivers of most common form of Lymphoma identified"},"content":{"rendered":"<p><span lang=\"EN-GB\">Lymphoma is the most common blood cancer, but the diagnosis belies a wildly diverse and little understood genetic foundation for the disease that hampers successful treatment.<\/span><br \/>\n<span lang=\"EN-GB\">An international research effort led by Duke Cancer Institute scientists has been working to better understand the genetic underpinnings of the most prevalent form of this cancer &#8212; diffuse large B cell lymphoma \u2013 and how those genes might play a role in patients\u2019 responses to therapies.<\/span><br \/>\n<span lang=\"EN-GB\">The researchers analysed tumour samples from 1,001 patients who had been diagnosed with diffuse large B cell lymphoma over the past decade. These patients had been treated at 12 institutions around the world.<\/span><br \/>\n<span lang=\"EN-GB\">Using whole exome sequencing, the researchers pinpointed 150 genetic drivers of the disease, many newly identified. The team then tested to see if there were any correlations between the genes and how well patients had responded to standard therapies. The team applied a genome editing technique known as CRISPR to knock out each of the 20,000 genes in lymphoma cells to identify those that are critical for lymphoma cells to grow. By assessing the genetic, CRISPR and clinical results, the researchers found several critical genetic links that could help guide treatments.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cThis work provides a comprehensive road map in terms of research and clinical priorities,\u201d said Sandeep Dav\u00e9, MD, professor of medicine at Duke. \u201cWe have very good data now to pursue new and existing therapies that might target the genetic mutations we identified. Additionally, this data could also be used to develop genetic markers that steer patients to therapies that would be most effective.\u201d<\/span><\/p>\n<p><span lang=\"EN-GB\">Duke Cancer Institute<\/span><br \/>\n<span lang=\"EN-GB\"><link http:\/\/www.dukecancerinstitute.org\/news\/researchers-identify-genetic-drivers-most-common-form-lymphoma _blank external-link-new-window \"Opens external link in new window\">www.dukecancerinstitute.org\/news\/researchers-identify-genetic-drivers-most-common-form-lymphoma<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lymphoma is the most common blood cancer, but the diagnosis belies a wildly diverse and little understood genetic foundation for the disease that hampers successful treatment. An international research effort led by Duke Cancer Institute scientists has been working to better understand the genetic underpinnings of the most prevalent form of this cancer &#8212; diffuse [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-964","post","type-post","status-publish","format-standard","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/964"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=964"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/964\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}