{"id":966,"date":"2020-08-26T09:32:39","date_gmt":"2020-08-26T09:32:39","guid":{"rendered":"https:\/\/clinlabint.3wstaging.nl\/link-between-bacterial-imbalances-and-breast-cancer\/"},"modified":"2021-01-08T11:09:06","modified_gmt":"2021-01-08T11:09:06","slug":"link-between-bacterial-imbalances-and-breast-cancer","status":"publish","type":"post","link":"https:\/\/clinlabint.com\/link-between-bacterial-imbalances-and-breast-cancer\/","title":{"rendered":"Link between bacterial imbalances and breast cancer"},"content":{"rendered":"<p><span lang=\"EN-GB\">In a newly published study, Cleveland Clinic researchers have uncovered differences in the bacterial composition of breast tissue of healthy women vs. women with breast cancer. The research team has discovered for the first time that healthy breast tissue contains more of the bacterial species Methylobacterium, a finding which could offer a new perspective in the battle against breast cancer.<\/span><br \/>\n<span lang=\"EN-GB\">Bacteria that live in the body, known as the microbiome, influence many diseases.<\/span><br \/>\n<span lang=\"EN-GB\">Most research has been done on the \u201cgut\u201d microbiome, or bacteria in the digestive tract. Researchers have long suspected that a \u201cmicrobiome\u201d exists within breast tissue and plays a role in breast cancer but it has not yet been characterized. The research team has taken the first step toward understanding the composition of the bacteria in breast cancer by uncovering distinct microbial differences in healthy and cancerous breast tissue.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cTo my knowledge, this is the first study to examine both breast tissue and distant sites of the body for bacterial differences in breast cancer,\u201d said co-senior author Charis Eng, M.D., Ph.D., chair of Cleveland Clinic\u2019s Genomic Medicine Institute and director of the Center for Personalized Genetic Healthcare. \u201cOur hope is to find a biomarker that would help us diagnose breast cancer quickly and easily.&nbsp; <\/span>In our wildest dreams, we hope we can use microbiomics right before breast cancer forms and then prevent cancer with probiotics or antibiotics.\u201d<br \/>\n<span lang=\"EN-GB\">The study examined the tissues of 78 patients who underwent mastectomy for invasive carcinoma or elective cosmetic breast surgery. In addition, they examined oral rinse and urine to determine the bacterial composition of these distant sites in the body.<\/span><br \/>\n<span lang=\"EN-GB\">In addition to the Methylobacterium finding, the team discovered that cancer patients\u2019 urine samples had increased levels of gram-positive bacteria, including Staphylococcus and Actinomyces. Further studies are needed to determine the role these organisms may play in breast cancer.<\/span><br \/>\n<span lang=\"EN-GB\">Co-senior author Stephen Grobymer, M.D., said, \u201cIf we can target specific pro-cancer bacteria, we may be able to make the environment less hospitable to cancer and enhance existing treatments. Larger studies are needed but this work is a solid first step in better understanding the significant role of bacterial imbalances in breast cancer.\u201d Dr. Grobmyer is section head of Surgical Oncology and director of Breast Services at Cleveland Clinic.<\/span><\/p>\n<p><span lang=\"EN-GB\">Cleveland Clinic<\/span><br \/>\n<span lang=\"EN-GB\"><link https:\/\/newsroom.clevelandclinic.org\/2017\/10\/05\/cleveland-clinic-researchers-find-link-between-bacterial-imbalances-and-breast-cancer\/ _blank external-link-new-window \"Opens external link in new window\">newsroom.clevelandclinic.org\/2017\/10\/05\/cleveland-clinic-researchers-find-link-between-bacterial-imbalances-and-breast-cancer\/<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a newly published study, Cleveland Clinic researchers have uncovered differences in the bacterial composition of breast tissue of healthy women vs. women with breast cancer. The research team has discovered for the first time that healthy breast tissue contains more of the bacterial species Methylobacterium, a finding which could offer a new perspective in [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/966"}],"collection":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/comments?post=966"}],"version-history":[{"count":0,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/posts\/966\/revisions"}],"wp:attachment":[{"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/media?parent=966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/categories?post=966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clinlabint.com\/wp-json\/wp\/v2\/tags?post=966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}