ProBioGen

ProBioGen and City of Hope ink license to use AGE1.CR.pIX vaccine manufacturing platform for cytomegalovirus vaccine

ProBioGen and City of Hope, one of the largest cancer research and treatment organizations in the United States, have signed an non-exclusive commercial license agreement that will allow City of Hope to manufacture its innovative synthetic MVA-based CMV vaccine using ProBioGen’s cell-based and scalable viral manufacturing platform AGE1.CR.pIX.

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Mogrify and Astellas initiate research collaboration on in vivo regenerative medicine approaches to address sensorineural hearing loss

Biopharmaceutical company Mogrify and Astellas Pharma have initiated a collaborative research agreement on in vivo regenerative medicine approaches to address sensorineural hearing loss.

Indica Labs

Indica Labs to collaborate with iCAIRD for development of an AI-based algorithm for automated reporting of lymph node status in colon cancer

Indica Labs, an industry leader in quantitative digital pathology and image management solutions, and The Industrial Centre for Artificial Intelligence Research in Digital Diagnostics (iCAIRD), will collaborate on the development of an AI-based digital pathology solution for the detection of cancer within lymph nodes from colorectal surgery cases. The primary aim of the research project […]

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Biomarkers for the early diagnosis of sepsis in burns: systematic review and meta-analysis

Li AT, Moussa A, Gus E et al. Ann Surg 2022;275(4):654–662

Fig 1 New Life ... Histopathology timeline boxed

New life for old cellular pathology records

We are probably all familiar with the problems of information storage and retrieval, where transition to newer systems, platforms, databases, etc, can mean that information previously stored can no longer be accessed easily, if at all. This article discusses how a system of digital methodology has been developed that gives immediate visibility and clinical utility […]

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Assessment of proliferative activity in breast cancer

Approaches, significance and challenges Cell proliferation is a hallmark of cancer associated with aggressiveness and response to chemotherapy. In breast cancer (BC), assessment of proliferation constitutes the main component of grading and help in management. Herein, we address the most common approaches for BC proliferation assessment, their limitations, and evolving applications to overcome these challenges.

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Conjunctival squamous intraepithelial neoplasia

The in situ stage of conjunctival squamous cell carcinoma is called conjunctival squamous intraepithelial neoplasia (CSIN). The use of terms such as Bowen’s disease and ocular surface squamous neoplasia are discouraged as their meanings vary and are prone to misinterpretation. The severity of squamous epithelial dysplasia is graded by the proportion of involved surface epithelium. […]

Mass spectrometry analysis of protein glycosylation and viral infectivity

The recent COVID-19 pandemic and race to develop vaccines against the causative agent, severe acute respiratory syndrome coronavirus 2, has reminded us of the important role that protein glycosylation plays in the mechanisms of pathogen infection and host immune response. CLI caught up with Dr Sanda and Dr Campos (both at Team Scientific Service Group […]

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Medical device components that inhibit bacterial growth

Vyon® porous plastics from Porvair Sciences are the perfect material for filtration applications in the healthcare and medical devicemarket

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PhoreMost enters multi-project drug target discovery collaboration with Roche

PhoreMost to deploy its SITESEEKER platform to identify novel targets for Roche’s discovery programmes