by Dr Jacqueline Gosink Growth hormone (GH), insulin like growth factor I (IGF 1) and IGF binding protein 3 (IGFBP 3) are central regulators of growth and metabolism. Measurement of these biomarkers supports the diagnosis of growth disorders such as GH deficiency in children and acromegaly in adults. The analytes also play an important role […]
Sarcopenia has a big impact on health as we age – and it’s not just about the risk of falls. It is estimated to affect 10–16% of the aging population but challenges with diagnosis mean that this is likely to be an underestimate. Current methods of analysing muscle all have limitations associated with them. CLI […]
Abnormal MET presence and activity are known to drive tumour growth, persistence and spread. However, although some patients respond well to current therapies many do not, which indicates that there are subtleties about the analysis of MET as a biomarker that have not been adequately analysed to date. CLI chatted with Dr Tony Navas (AbbVie, […]
Duchenne muscular dystrophy is a devastating progressive muscle disease that causes loss of ambulation by age 12 and premature death in early thirties. New gene therapy approaches are extending life span, but the physical assessments currently used make disease progression and therapy monitoring challenging, if not impossible. CLI chatted with Professor Yetrib Hathout and Ahmed […]
PCSK9 was originally identified because of its role in lipid metabolism. However, recent data is demonstrating its involvement in other pathologies such as sepsis and acute respiratory distress syndrome. CLI chatted with Emma Crossley (Queen’s University Belfast, UK) to find out more about the roles of PCSK9 in these diseases.
Tuberculosis (TB) is still a serious public health concern worldwide, with World Health Organization data suggesting an estimated 10.7 million people developed TB in 2024, with 1.23 million deaths, making TB a leading cause of death from a single infectious agent. Treatment of TB is challenging and requires a 6-month course of multiple antibiotics. This […]
Algorithms are commonly used in diagnostics and healthcare for producing risk scores, diagnoses, alerts, etc; guiding clinical decisions; and helping to standardize care. Some are so simple that you might not think of them as an algorithm: BMI, for example. Others are recognized as what we typically think of as an algorithm, such as estimated […]
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