Understanding the role of molecular testing in modern healthcare
HPV vaginal self-collection as a transformative tool for cervical cancer screening Screening for precancerous cytological changes has been a mainstay of the early detection of patients at risk of developing cervical cancer. Now, with the understanding that cervical cancer is caused by human papilloma-virus infection, screening has converted, largely, to primary detection of high-risk HPV […]
Cardiac amyloidosis is a progressive stiffening of the heart muscle that leads to heart failure. There are two main types of disease and treatment differs accordingly. Several cardiac biomarkers are useful for disease diagnosis, staging and therapeutic decision making. CLI chatted to Dr Andreea Foghis (Washington University in Saint Louis, MO, USA) to discover more […]
Polycystic ovary syndrome affects over 10% of all females and is now thought of as much more wide-ranging metabolic disorder than ‘just’ a disease of the female reproductive system. CLI chatted to James Hawley (Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK and Laboratory of Medical Science, Medical Research Council, London, UK) to find […]
Nurgül Vatansever, Vice President & General Manager for EMEA (Europe, Middle East and Africa) at Beckman Coulter Diagnostics, brings more than 30 years of global healthcare leadership to her role. In this interview, she shares insights on the newly unified EMEA region in Beckman Coulter Diagnostics, the evolving diagnostics landscape, the importance of innovation, and […]
Lyme disease can be treated simply and effectively if caught early. However, significant challenges are associated with current tests. CLI chatted to Prof. Monica Embers (Tulane National Biomedical Research Center, Tulane University, New Orleans, LA, USA) to discover more about her single-tier test process that allows effective diagnosis at early stages of the disease.
Diagnosis of central nervous system vasculitis caused by varicella zoster virus (VZV) infection requires detection of intrathecally synthesized anti-VZV antibodies. One way of doing this is to test paired serum and cerebrospinal fluid samples and to calculate the antibody index using the Reiber formula. This method is not commonly used in the USA but can […]
Challenges and applications Measuring concentrations of steroid hormones – specifically androgens and estrogens – is challenging because they are present at very low concentrations and are structurally very similar. CLI chatted to James Hawley to find out more about these difficulties and how the assays are beginning to be used to measure testosterone levels in […]
Background Lenses and microscopes The use of microscopy has been pivotal to the diagnosis of disease for hundreds of years. The earliest evidence for the use of magnification dates back to the 5th century BC and the use of simple microscopes and lenses in spectacles in the 13th century AD. Compound microscopes appeared in Europe […]
The global prevalence of celiac disease is around 1%, although it is likely that many people remain undiagnosed. Historically, diagnosis was usually made in younger children, but the condition can develop at any age and the incidence is increasing in adults. Traditionally, a biopsy has been required to confirm diagnosis, but increased endoscopy waiting times […]
May 2026
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