by Mahesh Kalikiri The evolution of next-generation sequencing (NGS) technologies is driving the development of novel solutions in genomics testing, but the associated technical challenges are limiting the roll out of wide-spread, rapid sequencing. In this article, Mahesh Kalikiri, Eppendorf EMEA, explores how automated liquid handling platforms are reducing variability and increasing throughput in NGS […]
by Dr Jacqueline Gosink Calprotectin is released during inflammatory responses and reflects local immune activation. While traditionally used to assess gastrointestinal conditions, it is showing increasing promise for evaluation of the inflammatory status in systemic autoimmune rheumatic diseases (SARDs). Enzyme-linked immunosorbent assay and chemiluminescence immunoassay technologies enable standardized measurement of circulating calprotectin and may support […]
by Dr Yoonyoung Lee Tumour heterogeneity and spatial organization within the tumour micro-environment are important factors influencing cancer progression and therapeutic response. Spatially resolved cell sorting technologies enable selective isolation of spatially defined cellular populations directly from tissue sections while preserving tissue context for downstream molecular analysis, thus supporting advances in tumour characterization and precision […]
Skin cancers are becoming increasingly common as people live longer and have higher levels of long-term sun exposure. CLI chatted to Dr Viktor Schnabel (Leipzig University, Leipzig, Germany) to find out more about how modern imaging technologies, particularly ex vivo confocal laser scanning microscopy, are being used to improve accurate diagnosis and treatment of skin […]
Congenital erythrocytosis is a very rare disorder of hematopoiesis that is typified by the presence of elevated red cell mass and puts patients at an increased risk of blood clots, heart attacks and stroke. Diagnosis is complicated because many environmental/lifestyle factors can also affect red blood cell levels but ultimately comes down to genetic screening […]
Understanding the role of molecular testing in modern healthcare
HPV vaginal self-collection as a transformative tool for cervical cancer screening Screening for precancerous cytological changes has been a mainstay of the early detection of patients at risk of developing cervical cancer. Now, with the understanding that cervical cancer is caused by human papilloma-virus infection, screening has converted, largely, to primary detection of high-risk HPV […]
Cardiac amyloidosis is a progressive stiffening of the heart muscle that leads to heart failure. There are two main types of disease and treatment differs accordingly. Several cardiac biomarkers are useful for disease diagnosis, staging and therapeutic decision making. CLI chatted to Dr Andreea Foghis (Washington University in Saint Louis, MO, USA) to discover more […]
Polycystic ovary syndrome affects over 10% of all females and is now thought of as much more wide-ranging metabolic disorder than ‘just’ a disease of the female reproductive system. CLI chatted to James Hawley (Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK and Laboratory of Medical Science, Medical Research Council, London, UK) to find […]
Nurgül Vatansever, Vice President & General Manager for EMEA (Europe, Middle East and Africa) at Beckman Coulter Diagnostics, brings more than 30 years of global healthcare leadership to her role. In this interview, she shares insights on the newly unified EMEA region in Beckman Coulter Diagnostics, the evolving diagnostics landscape, the importance of innovation, and […]
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