TECHNICAL NOTES & APPLICATIONS FOR LABORATORY WORK
1/ INTRODUCTION
The main flaw of traditional cell culture methods is the use of two-dimensional (2D) monolayers of cells, which are not a good representation of in vivo tissue environments. Today, there are various options for growing cells in 3D, including round-bottom surfaces, hydrogels or scaffold-based methods. However, for 3D cell culture to be assimilated at a faster rate by laboratories, there is a need for tools that enable 3D cell culture to be performed using routine 2D cell culture workflows. E.g. Tasks such as media exchanges and imaging cells can be challenging when working with 3D cell culture because cells are neither attached to plastic or grown on a flat surface. Magnetic 3D cell culture is the solution to perform 3D cell culture as easily as in 2D.
2/ GREINER BIO-ONE MAGNETIC 3D BIOPRINTING TECHNOLOGY
The principle of magnetic 3D bioprinting relies on the magnetization of cells with NanoShuttle™- PL, a biocompatible nanoparticle assembly of gold nanoparticles, ironoxide, and poly-L-lysine (PLL). The NanoShuttle™-PL magnetizes cells by electrostatically attaching to the cellmembranes via PLL. The reproducible formation of a single spheroid per well in an F-bottom plate with cell-repellent surface is induced by the magnetic forces of one magnet below each well within 15 min (Fig. 1). Then, spheroids are generally formed within hours, depending on the cell type. These structurally and biologically representative 3D models formed in vitro are ready to…
Download white paper to continue reading
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One syndromic panel that tests everything but your patience.
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As COVID-19 continues to impact countries worldwide, accurate screening is needed to establish serological status of different populations. Bio-Rad now offers the Platelia SARS-CoV-2 Total Ab assay, for the detection of total anti-nucleocapsid antibodies (IgM, IgA, IgG) to SARS-CoV-2. In one test, the assay helps identify the immune response to coronavirus SARS-CoV-2, the virus associated with COVID-19.
https://info.bio-rad.com/cdg-sars-cov-2-ous?WT.mc_id=200814028804 Read more
https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png003wmediahttps://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png3wmedia2020-12-23 00:00:002020-12-23 00:00:00COVID-19 Serology Testing for IVD
ender diagnostics, a Swiss company specializing in the development of rapid molecular biological tests, has launched ender MASS, its second CE-marked test to detect SARS-CoV-2, the virus which causes COVID-19. US FDA clearance is anticipated in September this year.
ender MASS is highly specific, easy-to-use and fast – providing results from a simple nasopharyngeal swab in 30 minutes. It is designed to enable rapid diagnosis for critical settings including schools, manufacturing facilities, travel, hospitals and care homes, as well as enabling centralized laboratories to accelerate and increase throughput.
ender diagnostics specializes in isothermal PCR-based test kits for laboratory and on-site diagnosis. It launched the ender LAB test in June 2020, which enables laboratories to directly detect SARS-CoV-2 on standard real-time PCR devices within 30 minutes, significantly faster than currently available PCR tests, which take several hours.
The newly approved ender MASS offers further benefits by enabling detection in a simplified and accelerated process, considerably reducing the workload for medical professionals and laboratories. It is designed to enable on-site and pop-up labs to operate rapid testing in diverse settings, potentially including travel-related locations such as airports and cruise ships. The simplified workflows and analysis mean laboratories can process up to eight times as many tests compared to conventional PCR testing over the same period.
The company is also moving ahead with development of a mobile point-of-care test for acute COVID-19 cases, called ender MOBILE. Launch in Europe is planned during Autumn this year.
For more information, visit: https://enderdiagnostics.com
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MAGNETIC 3D BIOPRINTING – HIGH-THROUGHPUT SPHEROID IMAGING AND ANALYSIS USING PERKINELMER ENSIGHT™ MULTIMODE PLATE READER
, /in Featured Articles /by 3wmediaTECHNICAL NOTES & APPLICATIONS FOR LABORATORY WORK
1/ INTRODUCTION
The main flaw of traditional cell culture methods is the use of two-dimensional (2D) monolayers of cells, which are not a good representation of in vivo tissue environments. Today, there are various options for growing cells in 3D, including round-bottom surfaces, hydrogels or scaffold-based methods. However, for 3D cell culture to be assimilated at a faster rate by laboratories, there is a need for tools that enable 3D cell culture to be performed using routine 2D cell culture workflows. E.g. Tasks such as media exchanges and imaging cells can be challenging when working with 3D cell culture because cells are neither attached to plastic or grown on a flat surface. Magnetic 3D cell culture is the solution to perform 3D cell culture as easily as in 2D.
2/ GREINER BIO-ONE MAGNETIC 3D BIOPRINTING TECHNOLOGY
The principle of magnetic 3D bioprinting relies on the magnetization of cells with NanoShuttle™- PL, a biocompatible nanoparticle assembly of gold nanoparticles, ironoxide, and poly-L-lysine (PLL). The NanoShuttle™-PL magnetizes cells by electrostatically attaching to the cellmembranes via PLL. The reproducible formation of a single spheroid per well in an F-bottom plate with cell-repellent surface is induced by the magnetic forces of one magnet below each well within 15 min (Fig. 1). Then, spheroids are generally formed within hours, depending on the cell type. These structurally and biologically representative 3D models formed in vitro are ready to… Download white paper to continue reading
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COVID-19 Serology Testing for IVD
, /in Product News /by 3wmediaAs COVID-19 continues to impact countries worldwide, accurate screening is needed to establish serological status of different populations. Bio-Rad now offers the Platelia SARS-CoV-2 Total Ab assay, for the detection of total anti-nucleocapsid antibodies (IgM, IgA, IgG) to SARS-CoV-2. In one test, the assay helps identify the immune response to coronavirus SARS-CoV-2, the virus associated with COVID-19.
https://info.bio-rad.com/cdg-sars-cov-2-ous?WT.mc_id=200814028804
Read more
ender diagnostics launches second CE-certified COVID-19 rapid test
, /in Product News /by 3wmediaender diagnostics, a Swiss company specializing in the development of rapid molecular biological tests, has launched ender MASS, its second CE-marked test to detect SARS-CoV-2, the virus which causes COVID-19. US FDA clearance is anticipated in September this year.
ender MASS is highly specific, easy-to-use and fast – providing results from a simple nasopharyngeal swab in 30 minutes. It is designed to enable rapid diagnosis for critical settings including schools, manufacturing facilities, travel, hospitals and care homes, as well as enabling centralized laboratories to accelerate and increase throughput.
ender diagnostics specializes in isothermal PCR-based test kits for laboratory and on-site diagnosis. It launched the ender LAB test in June 2020, which enables laboratories to directly detect SARS-CoV-2 on standard real-time PCR devices within 30 minutes, significantly faster than currently available PCR tests, which take several hours.
The newly approved ender MASS offers further benefits by enabling detection in a simplified and accelerated process, considerably reducing the workload for medical professionals and laboratories. It is designed to enable on-site and pop-up labs to operate rapid testing in diverse settings, potentially including travel-related locations such as airports and cruise ships. The simplified workflows and analysis mean laboratories can process up to eight times as many tests compared to conventional PCR testing over the same period.
The company is also moving ahead with development of a mobile point-of-care test for acute COVID-19 cases, called ender MOBILE. Launch in Europe is planned during Autumn this year.
Read more