porvair binding plate

Porvair Sciences introduces optimised microplates for affinity binding assays

Porvair Sciences new medium and high bind Krystal microplates set a new standard for uniform and reproducible capture of a wide range of biomolecules ready for affinity binding assays such as ELISA’s.
Manufactured from high-quality crystal polystyrene, these new automation-ready plates are available in a choice of ANSI / SLAS standard (96-well and breakable 8-well strip) formats. Offering working volumes up to 320 µl the new Krystal binding plates incorporate a flat bottom to ensure accurate assay detection.
Designed for hydrophobic passive adsorption of lipid-rich large biomolecules and antigens, including viral antigens, medium binding Krystal plates offer a binding capacity of approximately 100 to 200 ng IgG/cm².
The Krystal high binding plates are optimised for passive adsorption of proteins with different grades of hydrophilicity. Offering a binding capacity of 400 to 500 ng IgG/cm² these high bind plates are ideal for immunoassay of glycoproteins and serum samples.

  • For further information, visit: https://www.microplates.com/krystal-medium-and-high-bind/

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11 PRODUCT DYNEX

CE-marked Dynex Multiplier simplifies workflow

The CE-marked Dynex Multiplier is a fully automated analyser that simplifies workflow. From the research laboratory to the clinical lab, the Multiplier ease-of-use reduces the pre-analytical steps while meeting results output with the power of multiplexing and the simplicity of automated ELISA. At the core of the Multiplier efficiency are the powerful automated processes that save time for system set up, reagent preparation, and specimen loading. Dynex SmartPLEX technology allows the simultaneous processing of up to 6 assays in a single well from a single patient sample.
With its large capacity to process 100 samples and provide up to 1200 results for these samples, very high lab productivity and reagent savings can be achieved.
For more information, visit: https://www.dynextechnologies.com/multiplierelisa- mutliplexing-technology.php
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10 PRODUCT ALPHA LABS

Alpha Labs’ Pyrostar provides quick, reliable endotoxin and β-glucan testing

Endotoxin testing is a vital, regulatory mandated assay for all injectable or implantable products. Pyrostar, now available in the UK from Alpha Laboratories, enables in-house endotoxin testing, providing full control over one of the most important aspects of quality control and offering many benefits over outsourcing.
With samples tested in-house results are available as soon as the assay finishes. The flexible system offers assays in different formats and pack sizes, at a range of sensitivities, allowing you to tailor your testing and workflow to your needs.
The FUJIFILM Wako Pyrostar range provides three highly sensitive assays; Gel Clot Assay (GCA), Kinetic Turbidimetric Assay (KTA) and Kinetic Colorimetric Assay (KCA), for use with the ET-7000 toxinometer. These are all based on the long established and trusted Limulus Amebocyte Lysate (LAL) method, testing for the presence of bacterial endotoxins and β-glucans and ensuring that your products are safe and pyrogen free. The GCA and KTA assays have been approved by the FDA when used with the Part 11 software, PC and testing module set.
Alpha laboratories can supply all the reagents, accessories, consumables, equipment and support necessary for this testing, providing you a one stop shop for all your endotoxin testing needs.
For more information, visit www.alphalabs.co.uk
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8 PRODUCT THERMOFISHER

New Liquid Chromatography-Mass Spectrometry Workstream offers comprehensive solution for toxicology

Clinical research, forensic and anti-doping toxicology laboratories facing the challenges of analysing increasing numbers of analytes in biological matrices, can now easily and rapidly optimize their liquid chromatography-mass spectrometry (LC-MS) methods for targeted screening and quantification with the new Thermo Scientific Tox Explorer Collection.
The Tox Explorer Collection offers a comprehensive LC-MS workstream for toxicology assays. It consists of proven methods enabling toxicology laboratories to achieve accurate, high-resolution data, regardless of analyte type, matrix complexities or user expertise.
The Tox Explorer Collection consists of a comprehensive library of analytes, allowing for faster identification and targeted screening assays with 1,500 compounds confirmed in a single analysis.
The Thermo Scientific Tox Explorer Collection is compromised of the following components:

    “Toxicology laboratories must ensure they carry out reliable, reproducible and sensitive analyses with a quick turnaround, using numerous instruments and software to ensure thorough sample screening,” said Brad Hart, senior director, clinical research, chromatography and mass spectrometry, Thermo Fisher Scientific.
    “The Thermo Scientific Tox Explorer Collection provides a robust, consistent, all-in-one LC-MS workstream, with an extensive library of analytes to allow for high-performance, targeted analyte screening on a daily basis.”
    To accompany the Tox Explorer Collection, Thermo Fisher Scientific offers a strong customer support network, comprising a comprehensive training and application support package. The package is coupled with a complete start-up guide that includes installation and method instructions.
    For more information, visit: www.thermofisher.com/ToxExplorer
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    7 PRODUCT EKF

    PrimeStore MTM novel viral transport media successfully evaluated by Public Health England for SARS-CoV-2 inactivation

    EKF Diagnostics’ novel viral transport media PrimeStore MTM (Molecular Transport Medium) has been successfully evaluated for effective SARS-CoV-2 inactivation in a new study published by Public Health England (PHE). To work safely with live SARS-CoV-2 samples requires the use of high-containment laboratories. However, after inactivation SARS-CoV-2 material can be handled at a lower containment level, allowing more laboratories to undertake testing and thereby increasing COVID-19 testing capacity.
    The PHE study evaluated numerous commercially available reagents and laboratory formulations commonly used for viral inactivation protocols by public health agencies and research laboratories globally. All the reagents tested have been used during the current COVID-19 pandemic for sample transportation and subsequent molecular processing. A total of 23 commercial reagents designed for virus inactivation, clinical sample transportation and nucleic acid extraction were assessed by PHE for their ability to inactivate SARS-CoV-2.
    The study used TCID50 and blind passage techniques to test for any infectious virus still recoverable from all samples treated with the inactivation reagents. Notably, the study showed that PrimeStore MTM was the only commercially available transport reagent from the many tested from which no residual virus was detectable by either TCID50 or by the passaging of treated purified sample. This demonstrates the efficacy and safety of PrimeStore MTM in inactivating live SARS-CoV-2 samples whilst maintaining the ability to detect the target viral RNA.
    In addition to this successful PHE evaluation of its effectiveness at deactivating SARS-CoV-2, PrimeStore MTM is also an FDA cleared and CE-IVD marked sample collection device. PrimeStore MTM removes the need for all cold chain logistics including sample storage; RNA and DNA are perfectly preserved for downstream molecular processing for up to four weeks at room temperature. Furthermore, because samples are rapidly inactivated, the risk of infection is eliminated, meaning samples are ready for safe testing immediately on arrival at a laboratory.
    For more information, visit: www.ekfdiagnostics.com
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    5 PRODUCT RANDOX

    Randox Labs unveils ‘All in One’ COVID-19 diagnostic analyser

    Randox Laboratories has unveiled Randox Discovery, a revolutionary COVID-19 diagnostic analyser. The benchtop laboratory for molecular and immunoassay diagnostics is the first of its kind to combine sample preparation techniques and Biochip Technology – a patented multiplex testing platform – in one high throughput fully-automated analyser.
    Randox’s patented Biochip Technology allows simultaneous detection of hundreds of targets from a single sample. The technology is capable of detecting SARS-CoV-2 and differentiating between other respiratory pathogens with similar symptoms. It can detect all known strains of coronavirus comprising SARS-CoV-2, Sarbecovirus (SARS, SARS-like & SARS-CoV-2), coronavirus 229E, coronavirus NL63, coronavirus OC43 and coronavirus HKUI.
    The combination of both SARS-CoV-2 and Sarbecovirus on the panel provides added confidence in patient diagnosis and helps to reduce false positives or negatives. This ultimately enables better treatment decisions and allows for more effective isolation and de-isolation of suspected and confirmed cases.
    The Discovery has a rapid turnaround time with three hours to first batch of results and results for subsequent batches every hour after.
    It is fully automated enabling a single operator to run up to 3 Discovery analysers.
    For more information, visit: www.randox.com/randox-discovery/
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    4 PRODUCT DIASYS

    DiaSys introduces Procal-citonin FS fluid-stable, particle-enhanced immunoturbidimetric assay

    DiaSys has launched a fluid-stable, particleenhanced immunoturbidimetric assay for determination of procalcitonin (PCT) in serum and plasma on clinical chemistry analysers.
    Procalcitonin FS offers high precision at clinical cut-off levels for sepsis with a measuring range from 0.2 ng/mL to 50 ng/mL. Procalcitonin FS has an outstanding onboard and calibration stability. No prozone effect was observed up to 1000 ng/mL.
    The assay performance is complemented by high tolerance to endogenous interferents and common therapeutics used in sepsis management. Method comparisons of Procalcitonin FS show good comparability to established tests and present the new assay as a reliable alternative for clinical chemistry analysers.
    For more information, visit: www.diasys-diagnostics.com/products/reagents/ immunoturbidimetry/reagent-details/227- procalcitonin-fs/reagent.show
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    3 PRODUCT BD

    BD granted FDA clearance for BD FACSLyric Flow Cytometer with newly integrated BD FACSDuet Sample Preparation System

    BD (Becton, Dickinson and Company), a leading global medical technology company, has received 510(k) clearance from the U.S. FDA for the BD FACSLyric™ Flow Cytometer with the Integrated BD FACSDuet™ Sample Preparation System.
    The new integrated system enables clinical laboratories to fully automate the sample to answer process and improve their efficiency by reducing errors and limiting the manual user interactions required to run assays on the BD FACSLyric™ Flow Cytometer.
    The BD FACSDuet Sample Preparation System builds new capabilities into the BD portfolio of clinical flow cytometry solutions offering a pre-analytical system, that combined with the BD FACSLyric Flow Cytometer is the first truly walkaway sample-to-answer solution for clinical labs.
    Physical integration between the BD FACSDuet Sample Preparation System and the BD FACSLyric Flow Cytometer allows technicians to load samples and reagents’ samples are acquired and analysed on the BD FACSLyric Flow Cytometer. Data integration using the BD FACSLink™ Middleware Solution offers bidirectional communication between the instruments and connectivity with laboratory information systems.
    The BD FACSLyric™ Flow Cytometer with the integrated BD FACSDuet™ Sample Preparation System is now available as an in vitro diagnostic (IVD) system in the United States as well as countries recognizing the CE-IVD certification, which was achieved in March 2019.
    For more information, visit: www.bdbiosciences.com/en-us/instruments/ clinical-instruments/clinical-cell-analyzers/facslyric
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    1 PRODUCT BIO RAD

    Bio-Rad introduces StarBright Violet 515 Dye for flow cytometry

    Bio-Rad Laboratories, a global leader of life science research and clinical diagnostic products, has introduced StarBright Violet 515 (SBV515) Dye, the first of a new range of unique fluorescent nanoparticles, for use in flow cytometry. Star- Bright Dyes are conjugated to a growing range of antibodies and are compatible with most flow cytometers and experimental protocols.
    The StarBright Violet 515 Dye with an excitation maximum at 401 nanometre and emission maximum of 516 nanometre offers researchers improved brightness to resolve rare and low antigen density populations more easily. It has a narrow emission profile to reduce spillover into neighbouring filters and minimal excitation by other lasers, making it suitable for inclusion in multicolour panels.
    The dye is not susceptible to photobleaching, delivers high lot-to-lot reproducibility, and is stable at 4°C with no loss of signal to help ensure consistent staining and deliver reliable results. It has been tested in many common staining buffers and there is no requirement to use a special staining buffer, permitting easy integration into common experimental protocols without compromising performance. StarBright Violet 515 Dye is compatible with Bio-Rad’s ZE5 Cell Analyzer, S3e Cell Sorter, as well as other cytometers, and it is suitable for both conventional and spectral flow.
    Mike Blundell, Bio-Rad Product Manager, Life Science Group, commented: “StarBright Violet 515 Dye is brighter than other common dyes that emit at similar wavelengths. The dye is flexible enough to fit into any flow cytometry panel, allowing researchers to multiplex with ease regardless of flow cytometer and experimental protocol, and it offers a superior alternative for fluorophores that have emission maxima between 500 and 550 nanometres.”
    For more information, visit: www.bio-rad-antibodies.com/starbright
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    9C PRODUCT PROMEGA

    Promega introduces Spectrum Compact CE benchtop DNA analysis instrument with Hitachi High-Tech

    Promega has launched its benchtop capillary electrophoresis (CE) instrument, the Spectrum Compact CE System, developed in collaboration with Hitachi High-Tech. The personal CE system is an integrated DNA analysis instrument that enables life scientists in laboratories of all sizes to perform Sanger sequencing and fragment analysis at the bench.
    The Spectrum Compact CE System features:

    • flexible run scheduling
    • easy-to-use interface
    • convenient benchtop size
    • separate plug-and-play consumables
    • on-site installation and operational training

    The instrument supports applications such as microsatellite instability analysis, mixed sample analysis, forensic STR analysis, and cell line authentication. It processes up to 32 samples in a single run and can be controlled by either the integrated touchscreen or by additional software that allows access from any registered computer on the same network. Guided software brings capillary electrophoresis capabilities to the hands of any scientist in the laboratory regardless of skill level.
    “The Spectrum Compact CE is personal and that’s one of the huge advantages that scientists will see with this instrument,” commented Doug Storts, Promega Head of Research. “An individual can walk into the laboratory and with minimal training, be able to change all the consumables, select which chemistries they want to use for both DNA sequencing as well as for fragment analysis, and perform the experiment.”
    Promega is also offering extensive support to laboratories integrating a Spectrum Compact CE System into their workflow, including on-site instrument and software installation and operational training. Technical Services Scientists are prepared to assist with data analysis and summary reports, and Field Support and Validation Services Scientists are available to assist with maintenance and validation requirements.
    For more information, visit: www.promega.com/SpectrumCompactCE
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