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Total bile acids 21 FS

Dual purpose IVD reagent for reliable determination of total bile acids

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Measurement of steroid hormones

Challenges and applications Measuring concentrations of steroid hormones – specifically androgens and estrogens – is challenging because they are present at very low concentrations and are structurally very similar. CLI chatted to James Hawley to find out more about these difficulties and how the assays are beginning to be used to measure testosterone levels in […]

organic chemical reactions

AI framework achieves breakthrough in predicting multiple organic chemical reactions

Researchers at Wuhan University and the Shanghai Artificial Intelligence Laboratory have developed LoRA-Chem, a modular machine learning framework that accurately predicts diverse organic chemical reactions using a single unified model. The system achieves state-of-the-art performance whilst requiring only natural language descriptions of reactions as input.

KAIST profs

Chip-based system models drug-induced muscle and kidney damage in real time

Researchers at KAIST have developed a modular organ-on-a-chip platform that recreates the cascade of drug-induced rhabdomyolysis and acute kidney injury in laboratory conditions. The biomicrofluidic system allows muscle and kidney tissues to be connected or separated as needed, enabling precise observation of inter-organ interactions following exposure to medications such as statins and fibrates.

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New test reveals which antibiotics actually kill bacteria

Researchers at the University of Basel have developed a method that measures whether antibiotics truly kill bacteria, not just inhibit their growth. The technique, called Antimicrobial Single-Cell Testing, tracks millions of individual bacterial cells in real time and has demonstrated that a drug’s killing power – rather than growth inhibition alone – predicts treatment success […]

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Evaluation of AI colon biopsy screening tool errors

Background Lenses and microscopes The use of microscopy has been pivotal to the diagnosis of disease for hundreds of years. The earliest evidence for the use of magnification dates back to the 5th century BC and the use of simple microscopes and lenses in spectacles in the 13th century AD. Compound microscopes appeared in Europe […]

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Serology testing can allow a no-biopsy approach to coeliac disease diagnosis

The global prevalence of celiac disease is around 1%, although it is likely that many people remain undiagnosed. Historically, diagnosis was usually made in younger children, but the condition can develop at any age and the incidence is increasing in adults. Traditionally, a biopsy has been required to confirm diagnosis, but increased endoscopy waiting times […]

New mass spec innovation

New novel mass spectrometry technique enhances detection of low-abundance molecules

Researchers at Cold Spring Harbor Laboratory have developed a segmented ion accumulation method that significantly improves the sensitivity and dynamic range of mass spectrometry. The innovation, termed HDR-MS1, addresses a fundamental limitation in proteomics research by preventing abundant molecules from overwhelming rare analytes during analysis.

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Novel home finger-prick blood test detects Alzheimer’s disease pathology

A groundbreaking international study has demonstrated that Alzheimer’s disease biomarkers can be accurately detected using simple finger-prick blood samples collected at home and posted to laboratories without refrigeration. The DROP-AD project, involving 337 participants across seven European centres, found that capillary blood spots could measure key markers including phosphorylated tau 217 (p-tau217) with 86% accuracy […]

pangenomics at scale

New data compression technique transforms pangenomics research

Researchers at UC San Diego have developed PanMAN, a novel data structure that compresses pangenomic information up to 1,391 times more efficiently than existing formats whilst simultaneously encoding detailed evolutionary and mutational histories. The technique, published in Nature Genetics, enabled construction of a comprehensive SARS-CoV-2 pangenome from 8 million sequences using just 366 MB of […]