Latest issue of Clinical laboratory
November 2025
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Anti-laminin β4 – a new autoantibody marker in pemphigoid disease
, /in Autoimmunity & Allergy, Featured Articles /by panglobalLaminin β4 (lamβ4) has been identified as a novel target antigen in anti-p200 pemphigoid, a rare autoimmune disease manifesting with subepidermal blisters. Anti-lamβ4 antibodies bind to the region of the dermal–epidermal junction and demonstrate pathogenic effects. A recombinant-cell indirect immunofluorescence assay has been developed for specific detection of anti-lamβ4 antibodies.
Identification of putative breath biomarkers for detection of lymphoma
, /in Featured Articles, Hematology & Flow Cytometry /by panglobalVolatile organic compounds (VOCs) are released from our bodies in our breath, sweat, blood and urine as a result of metabolic activity and so provide a window on our metabolic and physiological status. These VOCs change in response to disease, providing the potential for disease-specific VOCs in the breath to be used as non-invasive biomarkers […]
ACD/Labs expands Katalyst D2D software capabilities for pharmaceutical development
, /in Product News /by panglobalACD/Labs has released version 25.4 of Katalyst D2D, extending the industry-leading workflow digitalisation software beyond its original high throughput experimentation applications to support process scale-up and material characterisation in pharmaceutical development. The enhanced platform enables pharmaceutical project teams to accelerate the design-make-test-analyse cycle from discovery through to clinical trials.
Point-of-care test for detection of the FKBP12 biomarker at single-molecule level
, /in Featured Articles, Rapid Tests & POC /by panglobalFK506 (tacrolimus) binding protein 12 (FKBP12) is involved in fundamental cellular processes as well as immunosuppression, neurodegenerative diseases and cancer. Hence, the ability to quickly and easily determine its levels is desirable. CLI caught up with Dr Pitruzzella, Dr Caminati and Prof. Cennamo to find out more about the point-of-care test that they have developed […]
Wexis introduces Atomizer to enhance section adhesion, precision
, /in Product News /by panglobalWexis has unveiled the Atomizer, a breakthrough in microtomy workflow designed to enhance section adhesion, precision, and efficiency.
OHAUS introduces IVD-compliant centrifuge range with low-impact refrigerant
, /in Product News /by panglobalOHAUS Corporation has introduced a new series of centrifuges designed for in vitro diagnostic applications, featuring natural refrigerant R290 with substantially reduced environmental impact compared to conventional cooling systems.
Azenta Life Sciences expands cap carrier portfolio for enhanced sample tube processing
, /in Product News /by panglobalAzenta Life Sciences has launched 24- and 48-format cap carriers to complement its existing 96-format solution, providing clinical laboratories with flexible, scalable options for automated sample tube management across diverse applications.
ProImmune unveils self-loading MHC Class I monomers for enhanced T cell research
, /in Product News /by panglobalProImmune Ltd has introduced ProVE SL Self-Loading MHC Class I Monomers, a new platform designed to provide researchers with greater flexibility in antigen-specific CD8+ T cell detection studies.
Alithea Genomics launches extraction-free RNA sequencing kit for 3D spheroid drug screening
, /in Product News /by panglobalAlithea Genomics has introduced MERCURIUS® Spheroid DRUG-seq, an RNA sequencing library preparation kit designed to streamline transcriptomic analysis of three-dimensional spheroid models without requiring conventional RNA extraction steps.
Trimero’s κλoneus kits offer alternative approach for Bence-Jones proteinuria detection
, /in Product News /by panglobalκλoneus Free Light Chain (FLC) kits from Spanish in vitro diagnostics manufacturer Trimero Diagnostics SL offer clinical laboratories an alternative approach for determining Bence-Jones proteinuria based on International Federation of Clinical Chemistry (IFCC) guidelines.