The Capillarys 3 system benefits from the latest technology advancements along with high throughput, high samples and reagents capacity, genuine walk-away, high-tech traceability, cap piercing and smart flexible workflow options. A variety of samples types can be used, serum, urine, whole blood, capillary blood and dry spots. Capillarys 3 works either dedicated to a high volume single assay or in multiassay mode. Using the well established Sebia capillary electrophoresis technology Capillarys 3 offers consistent results with current Capillarys/Minicap.
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ELISA and indirect immunofluorescence tests (IIFT) have been developed for sensitive and specific detection of antibodies against Zika virus in patient serum samples. The assays are suitable for diagnosing acute infections as well as for disease surveillance. In particular, serological analyses can aid the differentiation of infections with Zika virus, dengue virus and chikungunya virus, which manifest with similar symptoms and are endemic in much the same geographic regions. Anti-Zika Virus ELISA (IgM or IgG) are based on highly specific recombinant Zika NS1 protein which avoids cross reactivity with other flaviviruses. Data from panels of well characterized sera have confirmed that there is no cross reactivity with flaviviruses including dengue, West Nile, yellow fever and Japanese encephalitis viruses. In studies on clinically and serologically characterized samples the IgM and IgG ELISA showed 100% sensitivity and 100% specificity. Anti-Zika Virus IIFT (IgM or IgG) utilize Zika virus-infected cells as the antigenic substrate. Positive and negative results are evaluated by fluorescence microscopy. With the Arboviral Fever Mosaic 2 the Zika virus substrate is incubated in parallel with substrates for chikungunya virus and dengue virus serotypes 1 to 4. This BIOCHIP combination can help in the differential diagnosis of Zika, dengue and chikungunya virus infections. Due to the use of whole virus particles, cross reactivities between flavivirus antibodies can occur. Serological tests provide a longer window for diagnosis than direct detection methods, which are only effective during the viremic phase within the first week after onset of symptoms. Detection of specific IgM or a significant rise in specific IgG in a pair of samples taken seven to ten days apart is evidence of an acute infection. Serological analyses are also important for prenatal monitoring, screening of donated blood and epidemiological studies. Zika virus is the pathogenic agent of Zika fever, an infectious topical disease which manifests with fever, exanthema and arthritis. Zika virus infection has been linked to congenital malformations, in particular microcephaly, and neurological complications such as Guillain-Barré syndrome. The virus is transmitted by mosquitoes of the Aedes family. Zika virus is currently spreading explosively in the Americas.
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Eliminating the hassle of ‘in-house’ data printing, CILS provides immediate, custom printed durable laboratory labels for all applications. Working from any data format (spreadsheets, laboratory management systems etc), the company can print any industry barcode (Code 128, 2D Datamatix, Code 39 etc) onto a range of over 3,500 application-specific durable label material/adhesive combinations, resistant to the harshest laboratory processes including cryogenic freezer storage (-196°C), steam sterilization cycles, chemicals/ solvents, repeated handling etc. CILS durable laboratory barcode labels are constructed to any size, shape, colour, pre-printed corporate design and material/adhesive combination.
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Abdominal pain and diarrhoea are common symptoms of conditions ranging from chronic inflammatory bowel disease to infections of the digestive tract, celiac disease or irritable bowel syndrome. Complete blood count and other inflammatory parameters in the blood are also not specific to inflammation localized in the intestines, so diagnoses of inflammatory bowel disease are often made with considerable delay. On the other hand, people with functional diseases, such as irritable bowel syndrome are often referred to painful and actually needless diagnostic procedures. Calprotectin in stool is an ideal marker for differentiation between intestinal inflammation and irritable bowel syndrome. Elevated levels of calprotectin in stool samples are found in cases of inflammatory bowel disease, infectious gastroenteritis, or colorectal carcinoma. For functional disorders like irritable bowel syndrome, and in celiac disease, calprotectin levels are within the normal range. The detection of fecal calprotectin is a simple, non-invasive test that can reasonably be carried out before any imaging or endoscopy, and thus helps to avoid unnecessary, painful and costly colonoscopies in patients with functional diarrhoea. The non-invasive calprotectin tests can easily be performed in children and pregnant women, with no adverse effects. Calprotectin concentrations correlate with disease activity in ulcerative colitis and Crohn’s disease. They decline with response to therapy, and increasing calprotectin levels may indicate relapses even before clinical symptoms become evident. Calprotectin in stool samples is an accurate early indicator for intestinal inflammation and is now available for Orgentec’s Alegria instrument with fully automated walk-away design. The Alegria system allows for rapid automated analysis of single samples and up to 30 tests in only 90 minutes. There are no limits for sample selection. Laboratory parameters from autoimmunity (e.g. if celiac disease is suspected) or infectious disease serology can be analysed simultaneously in one single automated Alegria test run.
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