C173

Electronic pipettes

Ergonomically engineered to provide the highest level of comfort and precision, Acura electro electronic pipettes are available in three models. The 926X model comprises seven micropipettes, ranging in volumes from 0.1 to 1000μL; the 936 model includes three micropipettes with volumes ranging from 0.1 to 10mL; and the Acura electro 956 offers eight multichannel pipettes with dispensing volumes from 0.5 to 350µL in 8- or 12-channel configurations. A unique feature is that one control unit is capable of fitting on to any one of 27 volumetric assemblies. Each microprocessor-controlled pipette features a lightweight design for maximum hand comfort and control. Programming one of the six working modes is easy with intuitive software control. The modes include Forward, Reverse, Stepper, Dilute, Mixing and Tactile. The new Tactile mode simplifies gel loading and makes titration possible using a micropipette. Display information is reversible for right or left side reading. User-friendly features include a swift-set user calibration system, a pipetting cycle counter, an audible beep for switching on or off, a reduced shaft length on the 926XS micropipettes up to 1000µL, and the ability of the volumetric module to be autoclaved at 121°C. The height adjustment system allows the optimal fitting and ejection of a wide selection of tips, and tip ejection is facilitated with the low-pressure activation button. Pipettes automatically go into energy saving stand-by mode if unused. The battery pack can be charged quickly on the convenient charging station stand. The battery charge level is clearly visible on the liquid crystal display.
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C151

Nucleic acid purification kits

An educational video on the new range of KingFisher nucleic acid purification kits for enhanced sample processing provides a useful snapshot of the benefits and applications of automated sample processing using the instruments, as well as an overview of how the complete system can be tailored to meet the needs of each user. The full video can be viewed online, along with additional information such as application notes, brochures and protocols. The new kits combine seamlessly with the KingFisher magnetic particle processors to maximise the speed and efficiency of user workflow.
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C181

Urine protein concentrator for Bence Jones protein

A stand-alone, static urine concentrator that uses a regenerated cellulose membrane to recover more Bence Jones Proteins, giving it a high sensitivity, the UriCon is a self-standing, individual test so there is no cross contamination. Multiples of single devices can be clipped together to allow for a large frequency of daily testing. This device offers unique features such as the luer cap lid to seal the product for improved health and safety. The unique pressure valve can decrease the concentration time of the device even further.
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C186

Serum uromodulin ELISA

Uromodulin (Tamm-Horsfall protein) is the most abundant protein excreted in urine under physiological conditions. It is exclusively produced in the kidney and secreted into the urine via proteolytic cleavage. It has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases. Genome-wide association studies identified uromodulin as a risk factor for chronic kidney disease (CKD) and hypertension, and suggested that urine uromodulin could represent a useful biomarker for the development of CKD. Recently, serum uromodulin determination exhibited characteristics superior to its measurement in the urine. Low serum uromodulin concentrations were associated with ANCA vasculitis, SLE, polycystic kidney disease, IgA nephropathy and preeclampsia. Using the cut-off 125.4 ng/mL uromodulin had a unique clinical sensitivity of 92.1% and specificity of 100.0% showing that it might be used as a screening nephropathy marker. BioVendor’s patent for the use of the serum uromodulin determination for the diagnosis of nephropathy is pending.
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C170 01

Urine analyser

The Urilyzer 100 instrument offers a broad range of optimised user-friendly features. The touch-screen user interface improves data entry and allows manual entry of colour and turbidity from a predefined list or by an additional comment. Moreover, the system provides the user with a high level of customisation with flexible testing and reporting options. The intelligent database-driven data management provides multiple filter options. The Pro version additionally provides enhanced operator management and connectivity capabilities to meet the growing demands for compliance management and data capture. It also offers an automated QC analysis with QC test reminders and supports LOT code documentation. System security in the Pro version allows the allocation of different security levels to individual users.
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C172

Five infectious disease panels

Five new infectious disease panels, including a first-of-its-kind performance panel for parvovirus B19 have been launched. The HIV Genotype Performance Panel provides researchers with a diverse set of samples, both geographically and in terms of genotypes: eight of the nine panel members are HIV positive, representing eight different HIV-1 genotypes from seven countries. Made from cultured virus diluted in defibrinated plasma, this unique panel is designed to help researchers, manufacturers and labs develop, evaluate and troubleshoot a variety of HIV assays, including those for HIV RNA and the newest screening tests for combined HIV antigen and antibody. The Worldwide HBV DNA Performance Panel is a 20-member panel including samples from 10 countries with HBV genotypes ranging from A to H. It delivers a broad range of data, with information on genotype, drug resistance mutations and test results for, HBV DNA, HBsAg and HbeAg. The Anti-Hepatitis A Virus Mixed Titer Performance Panel offers customers a 21-member panel that includes members positive for IgG and IgM, contains specimens collected from 2000 to 2010, and represents a diverse range of HAV reactivities (from low to medium to high). Data are available for both new and established test methods, providing greater applicability across a broad range of laboratory and research settings. The Anti-CMV (Cytomegalovirus) Mixed Titer Performance Panel provides 21 naturally occurring panel members with data from twelve commercially available anti-CMV assays. It also features a detailed graphical representation of test member results, making it easier than ever to find and utilise relevant data. These five new infectious disease panels, as well as a diverse selection of other infectious disease panels, are available immediately worldwide.
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C150

Advanced plate options for immunoassay protocols

This newly released portfolio of immunoassay surfaces ensures that users get the best results from their assays. Passive binding surfaces are available to absorb medium to large biomolecules in a range of orientations. For more specific binding, the Nunc CovaLink plates facilitate coupling of molecules bearing a free carboxyl or phosphate group, enabling peptides, haptens and DNA to be effectively coupled. In addition, the Immobilizer amino plate forms stable covalent bonds with the free amino acids or sulphhydryl groups of the biomolecule, eliminating the need for a blocking step. Affinity capture surfaces offer even more specific binding, with reduced variability in molecular orientation and improved signal to noise ratio. In order to help users to select the best plate format to meet the demands of their application, the interactive and searchable immunoassay plate selector guide is a free resource, providing in-depth detail about the range of plates available and their applications.
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C171

Clostridium difficile detection kit

Clostridium difficile is one of the most prevalent nosocomial pathogens, mainly affecting patients after antibiotic treatment. Toxinogenic strains of C. difficile cause infections from mild diarrhoea to pseudomembranous colitis, potentially leading to death. The tissue-damaging enterotoxin (Toxin A) and the cytotoxin (Toxin B) produced by toxinogenic strains of C.difficile are responsible for the disease. Most of the algorithms used in laboratories to diagnose C.difficile described a two step methodology with a first test to identify the bacterium in order to exclude those specimens which are not positive for C.difficile from being tested with the second more expensive and time consuming test. The first line test should allow the detection of the enzyme glutamate dehydrogenase, which is specific for C. difficile, with an NPV value close to 100 %. Coris BioConcept has now developed such a C. difficile antigen detection assay, the Clostridium K-SeT, which uses specific antibodies directed against the glutamate dehydrogenase (GDH) enzyme of C. difficile. This test has been evaluated on 318 samples by a National Reference Laboratory and the following assay performances have been demonstrated: a sensitivity of 100 %, a specificity of 93 %, an NPV of 100 % and a PPV of 81,5 %.
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C145

Vitamin B12 levels suitable for anaemia monitoring

A new range of immunoassay controls provides clinically relevant levels of Vitamin B12 capable of accurately assessing the sensitivity of vitamin B12 assays. Vitamin B12 levels may be anywhere between 200 – 900 pg/mL with values under 200pg/mL indicating deficiency; signs of neurological deficiency or anaemia are usually evident in patients with levels below 150pg/mL. The Acusera Level 1 Immunoassay Premium, Immunoassay Premium Plus and Liquid Immunoassay controls contain low enough levels of Vitamin B12 (approx 150pg/mL) to assess assay performance at the clinical decision level, removing the need to purchase a separate anaemia control. In addition to low Vitamin B12 levels, the Premium and Premium Plus controls also contain ultra low levels of Ferritin and TSH, as well as a wide range of other immunoassay parameters, allowing consolidation of fertility hormones, thyroid hormones, kidney function tests, therapeutic drugs and other vitamins. In addition to this the Premium Plus control also contains many of the routinely run tumour markers including AFP, CA15-3, CA19-9, CA-125, CEA, PSA and Free-PSA.
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C168

Specific Salmonella detection agar

It is often a challenge to identify Salmonella species in samples heavily contaminated with competing microbiological flora, so Lab M has added new Xylose Lysine Tergitol-4 (XLT4) agar to its extensive range of products for Salmonella isolation and identification. XLT4 is a highly selective and very cost-effective medium for the specific detection and enhanced recovery of non-typhi Salmonella species from clinical (and other) samples. It enables labs to rapidly determine whether or not these pathogenic organisms are present, for effective monitoring even when faced with difficult materials.
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