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Early results suggest bile acids may be useful as diagnostic and prognostic markers for bone and muscle diseases

Historically, bile acids (BAs) were thought of as playing a role in lipid metabolism. In recent years, however, they have been found to affect the body in a much more wide-ranging way and are important in many normal functions and, therefore, also many disease states. CLI chatted to Dr Giovanny Rodriguez Blanco, lab leader at […]

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United expertise for your allergy diagnostics

Let’s embark on a new journey together!

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Albumin in Urine / CSF FS

Precise and early detection of kidney dysfunction

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Computational design reveals structural principles governing membrane protein stability

Scientists at Scripps Research have developed a computational approach for designing synthetic membrane proteins, uncovering critical atomiclevel interactions that govern protein folding and stability within cellular lipid environments. The methodology offers new insights into disease-related protein dysfunction and potential therapeutic targets. Membrane proteins constitute essential molecular machinery for cellular function, mediating substance transport, signal transmission, […]

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Tyramide signal amplification allows analysis of single circulating tumour cells and extracellular vesicles from glioblastoma liquid biopsies

Background What are circulating tumour cells and extracellular vesicles? Circulating tumour cells (CTCs) are cancer cells that have been shed from a primary tumour into the bloodstream or lymphatic system. They are carried around the body and can be the seeds that form metastases. Extracellular vesicles (EVs) are tiny lipid-bilayer bound particles that are shed […]

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Development of gender-specific thresholds in urine flow cytometry testing for urinary tract infection

Background A urinary tract infection (UTI) is an infection – usually bacterial – of any part of the urinary tract. Most commonly, a UTI would involve the lower urinary tract (urethra and bladder), and non-complicated lower UTIs are more common in women. Mild UTIs can resolve naturally, and pain killers, application of heat to the […]

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UTI diagnostic stewardship can improve antibiotic stewardship

It could be easy to imagine that the gold standard for diagnosis of urinary tract infection (UTI) is urine culturing with antimicrobial susceptibility testing to ensure prescription of the correct antibiotic. However, there are many aspects to the diagnosis of a UTI and an overreliance on urine culture alone can result in asymptomatic bacteriuria being […]

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Integra Biosciences launches $10.000 Future Lab Grant competition to modernise laboratory workflows

INTEGRA Biosciences has announced a competitive grant programme offering laboratories the opportunity to win $10,000 worth of pipetting and automation equipment to address operational challenges and enhance experimental efficiency.

Roche Elecsys Troponin T hs Gen 6 assay

Roche introduces sixth-generation troponin T test with enhanced diagnostic precision

Roche has unveiled results from its comprehensive TSIX Study Program evaluating a new high-sensitivity cardiac troponin T assay designed to improve acute myocardial infarction diagnosis in emergency settings. The sixth-generation test, recently granted CE Mark approval, demonstrates significant advances in sensitivity and accuracy for detecting cardiac events.

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Takara Bio launches defined medium for high-yield extracellular vesicle production

Takara Bio Europe has introduced Cellartis® MSC EV Wonder™, a chemically defined, xeno-free culture medium designed to address scalability challenges in mesenchymal stem cell-derived extracellular vesicle (MSC-EV) manufacturing. The product targets researchers developing cell-free therapeutic candidates for regenerative medicine and immunomodulation applications.