New Search

If you are not happy with the results below please do another search

4897 search results for:

3851

New assay may help predict which pancreatic lesions may become cancerous

A report describes a new simple molecular test to detect chromosomal abnormalities — biomarkers known as telomere fusions–in pancreatic tumour specimens and pancreatic cyst fluids. This assay may help predict the presence of high-grade or invasive pancreatic cancers requiring surgical intervention.More sophisticated imaging of the pancreas has led to increased detection of presymptomatic lesions. The […]

3852

Needle in a haystack

Clearing a major hurdle in the field of microbiome research, Harvard Medical School scientists have designed and successfully used a method to tease out cause-and-effect relationships between gut bacteria and disease.The team says the approach could propel research beyond mere microbiome-disease associations and elucidate true cause-effect relationships.The experiments, conducted in mice, also identify a previously […]

3853

The HLF-gene controls the generation of our long-term immune system

Blood stem cells give rise to all of our blood cells: the red blood cells that transport oxygen, the platelets that enable blood coagulation, and our immune cells that protect us from infections. Immune cells can, in turn, be divided into two groups; one that consists of cells with a very short life expectancy and […]

3854

Genetic-based model for predicting outcomes in primary myelofibrosis

A group of investigators from Mayo Clinic and multiple academic research centres in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease. “Myelofibrosis is a rare type of chronic leukemia that disrupts the body’s […]

3855

Breakthroughs in understanding genetic basis of aggressive prostate cancer

The retinoblastoma (RB) susceptibility gene was the first gatekeeper gene discovered for cancer. When it was removed or damaged, cancer thrived. Over the years, researchers have discovered methods that have allowed them to experimentally remove the RB gene in order to study it, but just how the gene’s loss made cancers more aggressive was poorly […]

3856

A risk factor for drug-induced skin disease identified

Researchers have identified a type of human leukocyte antigen (HLA) that is associated with the skin disease bullous pemphigoid (BP) in diabetic patients administered with DPP-4 inhibitory drugs.DPP-4 inhibitor (DPP-4i) is widely used to treat type 2 diabetes, but increased cases of bullous pemphigoid (BP) have been reported among patients taking the medicine. BP is […]

3857

Genetic analysis can improve depression therapy

The failure of drugs such as SSRIs, used to treat depression, can be a result of genetic variations in patients. Variations within the gene that encodes the CYP2C19 enzyme results in extreme differences in the levels of escitalopram achieved in patients. Prescribing the dose of escitalopram based on a patient’s specific genetic constitution would greatly […]

3858

Cancer’s gene-determined “immune landscape” dictates progression of prostate tumours

The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumours result in distinct paths of disease progression and response to therapy. Now, researchers […]

3859

Normal tissue BRCA1 methylation associated with risk for high-grade ovarian cancer

Germline mutations in certain genes are known to cause inherited cancer. Thus, individuals carrying mutations in the so-called breast cancer type I and II genes (BRCA1 and BRCA2) are highly prone to breast as well as ovarian cancers. In cancers, both gene mutations and aberrant regulation of genes (promoter inhibition by methylation of DNA) are […]

3860

New polygenic hazard score predicts when men develop prostate cancer

An international team, led by researchers at the University of California San Diego School of Medicine, has developed and validated a genetic tool for predicting age of onset of aggressive prostate cancer, a disease that kills more than 26,000 American men annually. The tool may potentially be used to help guide decisions about who to […]