Human Trefoil Factor 3 (TFF3) belongs to the trefoil factor family that also includes Trefoil Factors 1 and 2. It is mainly expressed in gastrointestinal tract, and in the mucous layer of the small and large intestine. Kidney is another major site of TFF3 expression. Overexpression of TFF3 has been reported in patients with various neoplasms including intestinal, pancreatic and prostate carcinomas. It is typically expressed in the lower oesophagus undergoing intestinal metaplasia. Urinary TFF3 protein levels are markedly reduced in response to renal tubular injury. Higher urinary TFF3 levels indicates ongoing repair of damaged kidney. Urinary TFF3 can be a marker of kidney disease. The Human TFF3 ELISA has enhanced BioVendor’s portfolio of diagnostic kits for renal disease, oncology, immune response, infection and inflammation, and metabolic syndrome. The kit is suitable for use with serum, plasma, urine and bronchoalveolar lavage samples.
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The newest instrument in Beckman Coulter’s Coulter Cellular Analysis System, the UniCel DxH Slidemaker Stainer (DxH SMS) prepares slides automatically based on slide orders received from laboratory information systems, using customisable criteria for blood film preparation and adjustable staining protocols. With hands-free operation and utilising innovative proprietary technology and lean design principles, the instrument is designed to increase laboratory productivity by providing users with state-of-the-art technology, a reliable system to minimise laboratory downtime and consistently excellent smear quality. Minimal operator intervention is required. Features are included to help laboratory personnel easily track samples and increase productivity. The sophisticated sample tracking tool allows users to find the slide location by simply searching for a particular patient. It includes default protocols as well as an open system where users can select a stain that is suitable for their laboratory. By combining and automating the slide stainer and slide maker into one module, a small footprint is offered and very little maintenance is required. Additionally, customised configurations are provided allowing labs to meet nearly every level of throughput and ‘load ‘n’ go’ capabilities to increase daily productivity levels. State-of-the-art software includes an intuitive interface, thermal printing and 2D barcode scanning.
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A heavy duty but compact and light-weight haematology analyser, Abacus 3 80 offers an optimal solution for hospitals, clinics and practices that require high quality and rapid complete blood count results. The built-in thermal printer, the automatic cleaning and the multilingual operating menu and large colour LCD with touch screen interface make the instrument very user-friendly. Providing 20 parameters and a complete blood count including 3-part differential, the instrument provides a throughput of 80 tests per hour, with results available in 45 seconds.
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Two innovative new ELISA systems provide separate detection of the diagnostically relevant antibodies in Bordetella pertussis infections: antibodies against pertussis toxin (PT) and antibodies against filamentous haemagglutinin (FHA). Independent determination of these antibodies is critical to enable a meaningful diagnostic interpretation, as emphasised in recent publications. Determination of IgG antibodies against PT is a front-line test for the serological diagnosis of pertussis infections; it is in many cases sufficient to perform a single determination of anti-PT IgG antibodies to detect an acute infection. Results of over 100 IU/mL provide a clear indication of a fresh infection or recent vaccination, and the second blood withdrawal can be omitted. If the titre is under 40 IU/mL no further tests are required unless clinical symptoms are suggestive of a pertussis infection. Only unclear results in the range 40 to 100 IU/mL need to be followed up with a second sample taken 7-10 days later. For a more in depth investigation, IgA antibodies against PT and IgG or IgA antibodies against FHA are measured separately. Age-dependent reference ranges are available on the internet.
The Anti-Bordetella pertussis Toxin ELISA (IgA or IgG) and the Anti-Bordetella FHA ELISA (IgA or IgG) correspond to current guidelines from European reference centres. Results are evaluated in international units (IU/mL) – a worldwide first for the detection of FHA antibodies. All processes, including incubation, evaluation and result archiving, can be fully automated. A supplementary product for Bordetella serodiagnostics, the immunoblot EUROLINE Bordetella pertussis (IgA or IgG), provides separate, parallel investigation of antibodies against adenylate cyclase toxin (ACT), PT and FHA and can also be fully automated using specially developed devices and software.
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Quo-Lab, an HbA1c analyser, combines high accuracy with low cost, easy to use technology. the analyser has been specifically developed to provide a point-of-care device that meets the needs of clinics and laboratories in countries where diabetes is an increasingly large public health issue and resources are limited, including countries in Asia, Africa and South America. The analyser is small, lightweight and only requires a simple procedure to deliver lab-accurate results within four minutes. The instrument uses the Boronate Affinity technique, which is recognised as being interference-free and unaffected by Hb variants. Up to 7,000 patient results can be stored.
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