Shimadzu introduces Analytical Intelligence value adding approach / Fully supports ‘Excellence in Science’ brand proposition / First solutions released with Analytical Intelligence functions /
Shimadzu, one of the world leaders in analytical instrumentation, applies a new qualitative approach to its hardware and software solutions, benefitting the users with a surplus of lab productivity and profitability. Under the umbrella of Analytical Intelligence, more and more analytical systems will be equipped with automated functions relieving users from organizational, input and processing works. As a first step, Analytical Intelligence functions are incorporated in selected system solutions such as the new Nexera series of (U)HPLC systems as well as the UV-i Selection spectrophotometers and the Nexis SCD-2030 sulfur chemiluminescence detection system.
Analytical Intelligence allows systems to detect and resolve issues automatically, enabling users to easily review instrument status, optimize resource allocation and achieve higher throughput. In a nutshell, the concept
covers automated support functions utilizing digital technology such as M2M, IoT and Artificial Intelligence (AI), enabling higher productivity with maximum reliability
supports the acquisition of high quality, reproducible data regardless of operator skill level for both routine use and demanding applications.
Analytical Intelligence makes lab management simple and enables higher productivity, maximum reliability and better connectivity.
Fully supports ‘Excellence in Science’ Analytical Intelligence goes hand in hand with Shimadzu’s ‘Excellence in Science’ brand value proposition, representing the company’s scientific and technological approach to always providing business and research solutions with the most modern analytical systems. Numerous ‘world’s firsts’ which meanwhile have become industrial standards as well as increasingly sensitive measuring methods substantiate this claim. With these technologies, Shimadzu enables customers from the most diverse industries to develop new products and solutions to promote and support consumer, patient and product safety as well as environmental protection.
The first solutions being equipped with Analytical Intelligence functions
The Nexera series of (U)HPLC systems maximizes reliability and uptime with fully unattended workflows that span from startup to shut-down, such as completion of auto-purge, equilibration, baseline checks and system suitability in advance as well as auto-diagnostics and auto-recovery capabilities. With remote mobile phase monitoring and integrated consumables management, the system maximizes uptime and reliability.
Featuring high resolution and highest sensitivity, the new UV-1900i UV-Vis spectrophotometer targets food, pharmaceutical, life sciences and chemical markets. Users can analyze more samples daily than ever before. The UV-1900i’s connectivity allows for direct printing (via PictBridge) without a PC. Several systems can share one printer. Data can be transferred to a PC via a router-based laboratory network.
The new UV-3600i Plus UV-Vis-NIR spectrophotometer includes a trinity of detectors to cover UV, UV-Vis and NIR regions. This system has been designed for highest sensitivity. The standard UV-3600i Plus is designed primarily for the measurement of liquid samples, but the wide range of accessories also enables measurement of solid samples.
With the Nexis SCD-2030 sulfur chemiluminescence detection system, Shimadzu meets a growing demand for easy operation and maintenance as well as high stability even during long term operation for highly selective and sensitive sulfur detection systems. The Nexis GC-2030, a next generation gas chromatograph, offers world-highest level of performance. It is based on the concept of superior usability and expandability for a wide variety of analytical applications, e.g. research and development and quality control in areas such as food, beverages, fragrances, gases and fuel cells.
Web summary Shimadzu, one of the world leaders in analytical instrumentation, applies a new qualitative approach to its hardware and software solutions, benefitting the users. It integrates Analytical Intelligence with automated support functions utilizing digital technology, such as M2M, IoT and Artificial Intelligence (AI) enabling higher productivity, maximum reliability and better connectivity. As a first step, selected system solutions incorporating Analytical Intelligence include the Nexera series of (U)HPLC systems, the new UV-i Selection spectrophotometers and the Nexis SCD-2030 sulfur chemiluminescence detection system. Read more
https://clinlabint.com/wp-content/uploads/sites/2/2020/08/Shimadzu_PR_A-ENG-19011_Figure_1-scaled.jpg144025603wmediahttps://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png3wmedia2020-08-26 09:16:522021-01-08 11:20:36The gateway to a surplus of lab productivity and profitability
HORIBA UK Ltd, Medical has introduced a new automated digital cell morphology solution in collaboration with CellaVision to help haematology laboratories simplify and expedite the performance of blood and body fluid differentials.
CellaVision’s digital cell morphology systems can now be integrated with HORIBA’s HELO automated haematology platform, enabling unique two-way data flow and rapid validation of cell morphology results. These combined systems automate a number of steps that would otherwise be undertaken manually, thus significantly enhancing laboratory workflows and increasing productivity.
The connectivity and bi-directional information sharing between CellaVision and HORIBA’s haematology systems uniquely support numerous aspects of digital blood cell morphology workflow. These save technician and cytologist time, support ease-of-use, improve flexibility and deliver more accurate results.
Mandy Campbell, Sales and Marketing Manager – Medical, HORIBA UK Ltd, commented, “Slide reading is a mandatory step in laboratories to confirm severe pathology diagnosis. By automating and digitising cell morphology workflow our new joint solution with CellaVision offers significant time saving and results standardisation to enable laboratories to work smarter and perform better.”
CellaVision systems leverage high-speed robotics and digital imaging to automatically locate and capture high-quality images of cells from slides produced by HORIBA’s Yumizen SPS slide maker following automatic slide reflex rules. By automating pre-classification and pre-characterisation of blood cell morphology, this slide digitalisation solution saves time and supports standardisation of slide reading when compared to the use of a traditional microscope for validation of blood smears. In turn, all results and alarms from HORIBA’s haematology analysers can be directly sent to CellaVision.
Data received from HORIBA haematology analysers are used by CellaVision systems in a number of ways to enhance workflows. As all slides are printed with 1D or 2D barcodes by the SPS, automatic distinction of whole blood and body fluids slides are possible without need for specific colour-coded racks when loading.
Furthermore, based on the HORIBA analyser’s WBC value, the CellaVision system will automatically adjust the quantity of pictures it captures to ensure sufficient and representative cell counting. This offers convenience in cases of leucopoenia or aplasia.
A range of CellaVision systems is available to integrate with HORIBA’s HELO haematology platform which can be selected based on a laboratory’s size and throughput. The CellaVision® DM9600 meets the needs of large laboratories with high-volume testing requirements, offering a loading capacity of 96 slides and throughput of 30 slides/hour. For large or small laboratories with lower volume testing needs, the CellaVision® DM1200 and CellaVision® DC-1 offer alternative options. Read more
https://clinlabint.com/wp-content/uploads/sites/2/2020/08/PRODUCT_HORIBA_MEDICAL.jpg40210003wmediahttps://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png3wmedia2020-08-26 09:16:522021-01-08 11:20:36HORIBA Medical and CellaVision collaborate on new automated Digital Cell Morphology solution
Nova Biomedical has launched their Stat EMS Basic blood testing system for ambulance and emergency care in CE mark countries. Stat EMS Basic measures fingerstick capillary lactate, glucose, ketone, hemoglobin, and hematocrit in six to 40 seconds with laboratory-quality results.
Stat EMS Basic is a smaller, non-connectivity version of Nova’s connectivity-capable Stat EMS system with the same test menu. Stat EMS Basic combines battery-operated StatStrip Xpress2 meters in a new, lightweight soft case that easily fits in a medic’s bag while holding all system components: meters, test strips, controls, and lancets. Test strips and controls require no refrigeration, making testing convenient and economical.
Specifically designed for ambulance, prehospital, and emergency use, Stat EMS Basic provides an important test menu and rapid results to aid with patient assessment and allow for faster, more effective emergency treatment. Stat EMS Basic also assists with rapid triage and determining the appropriate transport site for patients who have trauma, sepsis, anemia, acute coronary syndrome, or other critical illnesses.
Stat EMS Basic meters are easy to use; there is no calibration or coding and the testing procedure is as simple as fingerstick glucose testing performed by people with diabetes. Tiny capillary samples eliminate the need for venipuncture, saving time and reducing costs. Read more
https://clinlabint.com/wp-content/uploads/sites/2/2020/08/PRODUCT_NOVA_BIOMEDICAL.jpg9978473wmediahttps://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png3wmedia2020-08-26 09:16:522021-01-08 11:20:35Nova Biomedical launches Stat EMS Basic in CE Mark countries
Hemco has introduced the CleanAire II Ductless Hoods, designed to meet DH I requirements as defined by SEFA 9. This hood features a built-in carbon filtration system to adsorb non-toxic fumes and odors. It is equipped with an integral blower, vapor proof light, fan and light switches.
The hood superstructure is constructed of chemical and flame resistant, non-metallic (no rust) composite resin with a molded one-piece seamless interior fume chamber. A vertical sliding clear acrylic sash protects the user and contains the process fumes. The carbon filter adsorbs the fumes and then re-circulates the air back to the laboratory.
The CleanAire II Ductless Hoods are available in 24”, 30”, 35”, and 47” models and are shipped completely assembled and ready for operation.
For more information, visit: www.hemcocorp.com/caii.html Read more
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SP Scienceware has introduced ProCulture, a new workflow-minded product line for cell culture from Bel-Art and Wilmad-LabGlass brands, which covers multiple steps of the cell culture process from isolation to harvesting. Products include an array of Shaker Flasks, Spinner Flasks with a unique impeller that increases aeration and eliminates dead spots, and an Orbital Shaker Platform that converts an existing magnetic stir plate into an orbital shaker at a fraction of the cost of an orbital shaker.
Kathleen Hanek, Portfolio Manager for SP Scienceware, said: “The ProCulture line includes products that can simplify researchers’ cell culture experiments. It includes tried and true items such as shaker flasks and storage racks as well as products you can’t find anywhere else.”
A catalogue of products is available here Read more
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Danish company Samplix has launched its comprehensive service program to grant any laboratory access to the advantages of Xdrop™ technology. By partnering with the Samplix Service Team, researchers can leverage the unique Xdrop™ approach to address complex genomic questions, including gap closing, sequencing of repeat elements, detecting viral insertion sites, revealing unintended CRISPR edits, and more.
Xdrop™ is Samplix’s proprietary technology to enrich genomic regions longer than 100 kb from as little as 1 ng human genomic DNA and with single-molecule resolution. Unlike other target enrichment methods, Xdrop™ requires knowledge of only a short sequence within or flanking the target region for efficient target selection. Following targeted selection, multiple displacement amplification is applied to single DNA molecules compartmentalized in droplets. This ensures unbiased amplification of large DNA fragments that are representative of the target variation in the original sample. The output is ready for any short-read or long-read sequencing platform.
Commenting on the service, Henrik Pfundheller, VP Commercial Operations, said: “Our services program is designed to expertly manage workflow points that impact project success. We have regular customer consultations to establish clear research objectives and thus, secure the right experimental setup and sample quality strategy.”
The complete workflow is managed by an expert team of scientists and lab technicians with more than 10 years of experience in international genomics services, handling of precious sample types, project logistics, and dedicated customer care. Upon request, Samplix Services also performs and analyses long-read or short-read sequencing. Every step, including data processing and analysis, if requested, is carefully documented and discussed in a closing consultation.
“Whatever the reason behind a service request," added Pfundheller, “our team overcomes any challenge our customers experience, whether it relates to exploring a new application, getting help in tackling a difficult sequence, or just gaining access to the right equipment."
For more information, visit: www.samplix.com/services Read more
https://clinlabint.com/wp-content/uploads/sites/2/2020/08/samplix_Xdrop-scaled.jpg232825603wmediahttps://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png3wmedia2020-08-26 09:16:522021-01-08 11:20:34Samplix offers its proprietary Xdrop technology to other labs
Horizon Discovery Group, a leader in the application of gene editing and gene modulation for cell line engineering, says its cGMP-compliant CHOSOURCE™ platform has played a key role in generating a stable cell line for the development of an immunotherapy for autoimmune diseases. Horizon’s pharmaceutical-grade, stable Chinese Hamster Ovary (CHO) cells delivered high yields of monoclonal antibody for LAG-3 immunotherapy, enabling Immutep and Batavia Biosciences to reach an important milestone in the preclinical development of the compound.
Horizon’s gene-edited Glutamine Synthetase (GS) knockout CHO K1 cell line expression system, offered by Batavia Biosciences as part of its STEP®-mAb service, was used to generate a high yielding cell line for Immutep’s IMP761 product candidate, an agonist antibody targeting the immune checkpoint lymphocyte activation gene (LAG)-3. LAG-3 controls the signalling between specific immune cells, T cells and antigen presenting cells, which are responsible for the adaptive immune response, making it a promising focus for novel cancer therapies or for the treatment of autoimmune conditions, such as inflammatory bowel diseases, rheumatoid arthritis, and multiple sclerosis.
Horizon’s GS expression system facilitates the development of stable cell lines for the expression of antibodies and other recombinant proteins and is recognized in the industry and by regulators as suitable for high yield biomanufacturing. Its CHOSOURCE biomanufacturing platform helps companies to move from the DNA sequence of their potential biotherapeutic to clinical manufacturing as simply and rapidly as possible. The platform is versatile and suitable for a broad range of monoclonal antibody therapeutics, delivering higher-than-anticipated yields of less commonly used IgG4-based antibodies, such as IMP761.
Terry Pizzie, CEO, Horizon Discovery said: “We are dedicated to ensuring availability of key technologies that can improve affordability of medicines worldwide. Our CHOSOURCE biomanufacturing platform is empowering organizations from early stage start-ups to large pharmaceutical companies to drive efficiencies throughout development and production and has already been utilized in multiple successful innovative new drug filings.”
The complete CHOSOURCE system includes the GS knockout CHO K1 cell line, a comprehensive package of supporting documentation, and an expression vector supplied under license from DNATwoPointO, Inc.
• For more information, visit: https://horizondiscovery.com/navigation/cho-cells Read more
https://clinlabint.com/wp-content/uploads/sites/2/2020/08/Horizon_chosource_TerryPizzie_CEO.jpg163224493wmediahttps://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png3wmedia2020-08-26 09:16:522021-01-08 11:20:34Horizon Discovery CHOSOURCE platform supports development of immunotherapy for autoimmune diseases
Horizon Discovery Group, a global leader in the application of gene editing and gene modulation for cell line engineering, has added two new sample formats to its cell-based OncoSpan reference standards for use in the development and validation of workflows for cancer diagnostic assays.
Horizon’s OncoSpan range now includes formalin-fixed, paraffin-embedded (FFPE) and cell-free DNA (cfDNA) formats for mimicking solid tumors and liquid biopsy samples, respectively, in addition to its well-established genomic DNA (gDNA) format. Its cfDNA format offers one of the largest number of variants and genes, over 380 and 152 respectively, of any characterized reference standard to help standardize liquid biopsy testing.
These cell-line derived reference standards closely mimic patient samples and offer an unlimited and reproducible resource to help ensure consistency during the establishment and validation of diagnostic assays. All three formats are delivered with batch-specific, next-generation sequencing (NGS) data, orthogonally validated by ddPCR, to allow researchers to further validate their analysis pipeline.
For further information, visit: horizondiscovery.com/en/products/diagnostic-reference-standards/PIFs/OncoSpan-cfDNA Read more
https://clinlabint.com/wp-content/uploads/sites/2/2020/08/horizon_discovery-scaled.jpg256025603wmediahttps://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png3wmedia2020-08-26 09:16:522021-01-08 11:20:34Horizon Discovery extends coverage of OncoSpan reference standards to FFPE and Liquid Biopsy
Bio-Rad Laboratories, a specialist in life science research and clinical diagnostic products, has extended its range of recombinant monoclonal anti-idiotypic antibodies with the introduction of antibodies that are specific for ipilimumab (Yervoy) and the ipilimumab/CTLA-4 drug-target complex. These highly specific and high-affinity antibodies are suitable for bioanalytical and patient drug level monitoring assays for the immune checkpoint inhibitor: ipilimumab.
Bio-Rad also announced the launch of a range of anti-certolizumab pegol inhibitory antibodies to support the development of assays for therapeutic drug monitoring of tumor necrosis factor (TNF) alpha inhibitors.
Ipilimumab activates the immune system by inhibiting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a protein receptor that hinders the destruction of cancerous cells, to treat cancers such as melanoma. The four anti-ipilimumab antibodies inhibit the binding of the drug to its target, CTLA-4, and therefore detect free drug. These antibodies are suitable for developing pharmacokinetic (PK) bridging ELISAs and being used as a surrogate positive control (or reference standard) for anti-drug antibody assays. The drug-target complex binder specifically recognizes the ipilimumab/CTLA-4 complex and can be used as the detection antibody in a PK antigen capture assay as an alternative format to the bridging ELISA.
The recombinant monoclonal anti-idiotypic antibodies are generated using the Human Combinatorial Antibody Library (HuCAL®) and CysDisplay®, a proprietary method of phage display with guided selection methods to obtain highly targeted reagents. The recombinant production method also ensures a consistent and secure supply.
The anti-ipilimumab antibodies are approved for in vitro research and for commercial applications of in vitro testing services that support preclinical and clinical drug and biosimilar development and patient monitoring. Anti-certolizumab pegol inhibitory antibodies
The range of recombinant monoclonal anti-idiotypic antibodies comprises three antibodies that are highly specific for the monoclonal antibody Fab fragment certolizumab pegol (Cimzia) and inhibit the binding of this drug to its target: TNF alpha. The antibodies are fully human in full length IgG format and can be used as a surrogate positive control or calibration standard for an ADA assay to measure levels of patient anti-drug antibodies.
TNF alpha inhibitors are used to treat a wide range of inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and psoriasis. The levels of serum drug and ADA concentrations are monitored in patients receiving TNF alpha antagonists to help guide clinical decision making, optimize treatment, improve outcomes, and reduce healthcare costs.
The anti-certolizumab pegol antibodies are approved for in vitro research and for commercial applications of in vitro testing services that support preclinical and clinical drug and biosimilar development and patient monitoring. Read more
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Provides high efficiency, saves space and enables multi-sample processing / Customer- and application-specific solution / Time-saving by simplified, fast operation
Shimadzu, one of the world leaders in analytical instrumentation, has announced the release of its new Nexera Prep Series Preparative Purification Liquid Chromatograph (LC). “Preparative HPLC” is a process in which specific substances are separated and purified from samples. The new Nexera Prep Series provides better prep processes for extraction of functional and impurity components, as well as purification of target compounds in the pharmaceutical, chemical and food industries. This product dramatically improves productivity via flexible scalability and an efficient, user friendly preparative workflow. Customer- and application-specific solution The Nexera Prep Series consists of multiple related products with the LC units as the core. Users select a pump, autosampler and detector to build a system according to the purpose of the preparative work. Systems can be configured using related products such as the LH-40 Liquid Handler, FRC-40 Fraction Collector, Shim-pack Scepter LC Column for Analysis and Preparative Work, and Column Hub.
Preparative purification is generally performed following a multi-step workflow, which requires experience and time:
Selection of system configuration and preparative column size based on the amount
of purified sample or injection volume required
Selection of fraction collector and container size according to the intended purpose
Investigation of separation conditions in analytical scale
Optimization of preparative LC conditions
Confirmation of the purity of collected fractions
In addition to these steps, in some cases salts need to be removed or solvent needs to be evaporated after purification, requiring additional time and effort. Time-saving by simplified, fast operation The Nexera Prep Series reduces the time spent on examining conditions using the software’s fractionation simulation function. It also enables simplified, fast operation in transition from analytical to preparative scale, with a column portfolio that covers a wide range of sizes. Furthermore, Shimadzu’s unique UFPLC (Ultra Fast Preparative and Purification LC) high-purity purification system reduces the time required for powderization via the elution of desalted target components with an organic solvent. This product satisfies a number of user demands, such as efficient desalting and powderization, multi-sample and multi-fraction analysis, effective separation at low cost and the ability to check the purity.
Specifically, the product can be used for the following purposes:
Concentration and purification of immunosuppressive agents
Preparative work for impurities in degradants of medicinal agents
Separation and purification of functional components from natural materials
Consecutive analysis to separate and purify polymers and their additives and confirm the purity
The Nexera Prep Purification LC System provides new features to simplify the preparative workflow:
Reduces the time required for investigating conditions With the fractionation simulation function of the LabSolutions analysis software and the Shim-pack Scepter LC column for analytical and preparative HPLC, which offers excellent scalability, the product reduces the time required for investigating preparative work conditions. The LH-40 Liquid Handler can be used both, as a fraction collector and as an autosampler for large-volume injection with liquid surface detection function (option). It also enables seamless purity checks through re-injection (option) of collected sample after fractionation. Additional features including a sample rescue protocol to collect the sample from the system if an error occurs after an injection, a function to automatically extract the target peaks only, and high-purity preparative purification using detector signals from up to four channels, enable more efficient operation.
UFPLC high-purity purification system Samples must be in a state of concentrated solution or dry powder to analyze their structure or to store them. When a solution contains water, it takes time to dry and concentrate it. When a salt such as trifluoroacetate has been added, it remains in the crystal of the compound, lowering the purity and negatively influencing pharmacokinetic studies and other tests. Shimadzu’s unique, automated UFPLC purification system introduces fractions containing the target compound, separated in a preparative column, into a trap column. Salt and water are then washed off and elution is induced with an organic solvent. This reduces the time required for drying, providing compounds with a high level of purity.
Flexible system scalability Both the LH-40 Liquid Handler and FRC-40 Fraction Collector are designed to save installation space, requiring only half the space of other vendors’ products. They support containers of a form and size suitable for the recovered quantity. Up to six units can be connected, so up to 3240 10 mm diameter test tubes can be placed. Using the new Column Hub, up to six columns and four flow-line switching valves can be installed, enabling the compact configuration of various systems.
Web summary Shimadzu has announced the release of its new Nexera Prep Series Preparative Purification Liquid Chromatograph (LC). It provides better prep processes for extraction of target compounds and impurities during drug discovery in the pharmaceutical industry and purification of functional components in the chemical and food industries. This product improves productivity dramatically via efficient preparative workflows using LC or LC-MS methodology.
Web link: www.shimadzu.eu/nexera-prep Read more
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The gateway to a surplus of lab productivity and profitability
, /in Product News /by 3wmediaShimadzu introduces Analytical Intelligence value adding approach /
Fully supports ‘Excellence in Science’ brand proposition /
First solutions released with Analytical Intelligence functions /
Shimadzu, one of the world leaders in analytical instrumentation, applies a new qualitative approach to its hardware and software solutions, benefitting the users with a surplus of lab productivity and profitability. Under the umbrella of Analytical Intelligence, more and more analytical systems will be equipped with automated functions relieving users from organizational, input and processing works. As a first step, Analytical Intelligence functions are incorporated in selected system solutions such as the new Nexera series of (U)HPLC systems as well as the UV-i Selection spectrophotometers and the Nexis SCD-2030 sulfur chemiluminescence detection system.
Analytical Intelligence allows systems to detect and resolve issues automatically, enabling users to easily review instrument status, optimize resource allocation and achieve higher throughput. In a nutshell, the concept
Fully supports ‘Excellence in Science’
Analytical Intelligence goes hand in hand with Shimadzu’s ‘Excellence in Science’ brand value proposition, representing the company’s scientific and technological approach to always providing business and research solutions with the most modern analytical systems. Numerous ‘world’s firsts’ which meanwhile have become industrial standards as well as increasingly sensitive measuring methods substantiate this claim. With these technologies, Shimadzu enables customers from the most diverse industries to develop new products and solutions to promote and support consumer, patient and product safety as well as environmental protection.
The first solutions being equipped with Analytical Intelligence functions
Web summary
Shimadzu, one of the world leaders in analytical instrumentation, applies a new qualitative approach to its hardware and software solutions, benefitting the users. It integrates Analytical Intelligence with automated support functions utilizing digital technology, such as M2M, IoT and Artificial Intelligence (AI) enabling higher productivity, maximum reliability and better connectivity. As a first step, selected system solutions incorporating Analytical Intelligence include the Nexera series of (U)HPLC systems, the new UV-i Selection spectrophotometers and the Nexis SCD-2030 sulfur chemiluminescence detection system.
Read more
HORIBA Medical and CellaVision collaborate on new automated Digital Cell Morphology solution
, /in Product News /by 3wmediaHORIBA UK Ltd, Medical has introduced a new automated digital cell morphology solution in collaboration with CellaVision to help haematology laboratories simplify and expedite the performance of blood and body fluid differentials.
CellaVision’s digital cell morphology systems can now be integrated with HORIBA’s HELO automated haematology platform, enabling unique two-way data flow and rapid validation of cell morphology results. These combined systems automate a number of steps that would otherwise be undertaken manually, thus significantly enhancing laboratory workflows and increasing productivity.
The connectivity and bi-directional information sharing between CellaVision and HORIBA’s haematology systems uniquely support numerous aspects of digital blood cell morphology workflow. These save technician and cytologist time, support ease-of-use, improve flexibility and deliver more accurate results.
Mandy Campbell, Sales and Marketing Manager – Medical, HORIBA UK Ltd, commented, “Slide reading is a mandatory step in laboratories to confirm severe pathology diagnosis. By automating and digitising cell morphology workflow our new joint solution with CellaVision offers significant time saving and results standardisation to enable laboratories to work smarter and perform better.”
CellaVision systems leverage high-speed robotics and digital imaging to automatically locate and capture high-quality images of cells from slides produced by HORIBA’s Yumizen SPS slide maker following automatic slide reflex rules. By automating pre-classification and pre-characterisation of blood cell morphology, this slide digitalisation solution saves time and supports standardisation of slide reading when compared to the use of a traditional microscope for validation of blood smears. In turn, all results and alarms from HORIBA’s haematology analysers can be directly sent to CellaVision.
Data received from HORIBA haematology analysers are used by CellaVision systems in a number of ways to enhance workflows. As all slides are printed with 1D or 2D barcodes by the SPS, automatic distinction of whole blood and body fluids slides are possible without need for specific colour-coded racks when loading.
Furthermore, based on the HORIBA analyser’s WBC value, the CellaVision system will automatically adjust the quantity of pictures it captures to ensure sufficient and representative cell counting. This offers convenience in cases of leucopoenia or aplasia.
A range of CellaVision systems is available to integrate with HORIBA’s HELO haematology platform which can be selected based on a laboratory’s size and throughput. The CellaVision® DM9600 meets the needs of large laboratories with high-volume testing requirements, offering a loading capacity of 96 slides and throughput of 30 slides/hour. For large or small laboratories with lower volume testing needs, the CellaVision® DM1200 and CellaVision® DC-1 offer alternative options.
Read more
Nova Biomedical launches Stat EMS Basic in CE Mark countries
, /in Product News /by 3wmediaNova Biomedical has launched their Stat EMS Basic blood testing system for ambulance and emergency care in CE mark countries. Stat EMS Basic measures fingerstick capillary lactate, glucose, ketone, hemoglobin, and hematocrit in six to 40 seconds with laboratory-quality results.
Stat EMS Basic is a smaller, non-connectivity version of Nova’s connectivity-capable Stat EMS system with the same test menu. Stat EMS Basic combines battery-operated StatStrip Xpress2 meters in a new, lightweight soft case that easily fits in a medic’s bag while holding all system components: meters, test strips, controls, and lancets. Test strips and controls require no refrigeration, making testing convenient and economical.
Specifically designed for ambulance, prehospital, and emergency use, Stat EMS Basic provides an important test menu and rapid results to aid with patient assessment and allow for faster, more effective emergency treatment. Stat EMS Basic also assists with rapid triage and determining the appropriate transport site for patients who have trauma, sepsis, anemia, acute coronary syndrome, or other critical illnesses.
Stat EMS Basic meters are easy to use; there is no calibration or coding and the testing procedure is as simple as fingerstick glucose testing performed by people with diabetes. Tiny capillary samples eliminate the need for venipuncture, saving time and reducing costs.
Read more
CleanAire II Ductless Hoods designed to meet DH I as defined by SEFA 9
, /in Product News /by 3wmediaHemco has introduced the CleanAire II Ductless Hoods, designed to meet DH I requirements as defined by SEFA 9. This hood features a built-in carbon filtration system to adsorb non-toxic fumes and odors. It is equipped with an integral blower, vapor proof light, fan and light switches.
The hood superstructure is constructed of chemical and flame resistant, non-metallic (no rust) composite resin with a molded one-piece seamless interior fume chamber. A vertical sliding clear acrylic sash protects the user and contains the process fumes. The carbon filter adsorbs the fumes and then re-circulates the air back to the laboratory.
The CleanAire II Ductless Hoods are available in 24”, 30”, 35”, and 47” models and are shipped completely assembled and ready for operation.
For more information, visit: www.hemcocorp.com/caii.html
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SP Scienceware launches ProCulture product line for cell culture
, /in Product News /by 3wmediaSP Scienceware has introduced ProCulture, a new workflow-minded product line for cell culture from Bel-Art and Wilmad-LabGlass brands, which covers multiple steps of the cell culture process from isolation to harvesting. Products include an array of Shaker Flasks, Spinner Flasks with a unique impeller that increases aeration and eliminates dead spots, and an Orbital Shaker Platform that converts an existing magnetic stir plate into an orbital shaker at a fraction of the cost of an orbital shaker.
Kathleen Hanek, Portfolio Manager for SP Scienceware, said: “The ProCulture line includes products that can simplify researchers’ cell culture experiments. It includes tried and true items such as shaker flasks and storage racks as well as products you can’t find anywhere else.”
A catalogue of products is available here
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Samplix offers its proprietary Xdrop technology to other labs
, /in Product News /by 3wmediaDanish company Samplix has launched its comprehensive service program to grant any laboratory access to the advantages of Xdrop™ technology. By partnering with the Samplix Service Team, researchers can leverage the unique Xdrop™ approach to address complex genomic questions, including gap closing, sequencing of repeat elements, detecting viral insertion sites, revealing unintended CRISPR edits, and more.
Xdrop™ is Samplix’s proprietary technology to enrich genomic regions longer than 100 kb from as little as 1 ng human genomic DNA and with single-molecule resolution. Unlike other target enrichment methods, Xdrop™ requires knowledge of only a short sequence within or flanking the target region for efficient target selection. Following targeted selection, multiple displacement amplification is applied to single DNA molecules compartmentalized in droplets. This ensures unbiased amplification of large DNA fragments that are representative of the target variation in the original sample. The output is ready for any short-read or long-read sequencing platform.
Commenting on the service, Henrik Pfundheller, VP Commercial Operations, said: “Our services program is designed to expertly manage workflow points that impact project success. We have regular customer consultations to establish clear research objectives and thus, secure the right experimental setup and sample quality strategy.”
The complete workflow is managed by an expert team of scientists and lab technicians with more than 10 years of experience in international genomics services, handling of precious sample types, project logistics, and dedicated customer care. Upon request, Samplix Services also performs and analyses long-read or short-read sequencing. Every step, including data processing and analysis, if requested, is carefully documented and discussed in a closing consultation.
“Whatever the reason behind a service request," added Pfundheller, “our team overcomes any challenge our customers experience, whether it relates to exploring a new application, getting help in tackling a difficult sequence, or just gaining access to the right equipment."
For more information, visit: www.samplix.com/services
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Horizon Discovery CHOSOURCE platform supports development of immunotherapy for autoimmune diseases
, /in Product News /by 3wmediaHorizon Discovery Group, a leader in the application of gene editing and gene modulation for cell line engineering, says its cGMP-compliant CHOSOURCE™ platform has played a key role in generating a stable cell line for the development of an immunotherapy for autoimmune diseases. Horizon’s pharmaceutical-grade, stable Chinese Hamster Ovary (CHO) cells delivered high yields of monoclonal antibody for LAG-3 immunotherapy, enabling Immutep and Batavia Biosciences to reach an important milestone in the preclinical development of the compound.
Horizon’s gene-edited Glutamine Synthetase (GS) knockout CHO K1 cell line expression system, offered by Batavia Biosciences as part of its STEP®-mAb service, was used to generate a high yielding cell line for Immutep’s IMP761 product candidate, an agonist antibody targeting the immune checkpoint lymphocyte activation gene (LAG)-3. LAG-3 controls the signalling between specific immune cells, T cells and antigen presenting cells, which are responsible for the adaptive immune response, making it a promising focus for novel cancer therapies or for the treatment of autoimmune conditions, such as inflammatory bowel diseases, rheumatoid arthritis, and multiple sclerosis.
Horizon’s GS expression system facilitates the development of stable cell lines for the expression of antibodies and other recombinant proteins and is recognized in the industry and by regulators as suitable for high yield biomanufacturing. Its CHOSOURCE biomanufacturing platform helps companies to move from the DNA sequence of their potential biotherapeutic to clinical manufacturing as simply and rapidly as possible. The platform is versatile and suitable for a broad range of monoclonal antibody therapeutics, delivering higher-than-anticipated yields of less commonly used IgG4-based antibodies, such as IMP761.
Terry Pizzie, CEO, Horizon Discovery said: “We are dedicated to ensuring availability of key technologies that can improve affordability of medicines worldwide. Our CHOSOURCE biomanufacturing platform is empowering organizations from early stage start-ups to large pharmaceutical companies to drive efficiencies throughout development and production and has already been utilized in multiple successful innovative new drug filings.”
The complete CHOSOURCE system includes the GS knockout CHO K1 cell line, a comprehensive package of supporting documentation, and an expression vector supplied under license from DNATwoPointO, Inc.
• For more information, visit: https://horizondiscovery.com/navigation/cho-cells
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Horizon Discovery extends coverage of OncoSpan reference standards to FFPE and Liquid Biopsy
, /in Product News /by 3wmediaHorizon Discovery Group, a global leader in the application of gene editing and gene modulation for cell line engineering, has added two new sample formats to its cell-based OncoSpan reference standards for use in the development and validation of workflows for cancer diagnostic assays.
Horizon’s OncoSpan range now includes formalin-fixed, paraffin-embedded (FFPE) and cell-free DNA (cfDNA) formats for mimicking solid tumors and liquid biopsy samples, respectively, in addition to its well-established genomic DNA (gDNA) format. Its cfDNA format offers one of the largest number of variants and genes, over 380 and 152 respectively, of any characterized reference standard to help standardize liquid biopsy testing.
These cell-line derived reference standards closely mimic patient samples and offer an unlimited and reproducible resource to help ensure consistency during the establishment and validation of diagnostic assays. All three formats are delivered with batch-specific, next-generation sequencing (NGS) data, orthogonally validated by ddPCR, to allow researchers to further validate their analysis pipeline.
For further information, visit: horizondiscovery.com/en/products/diagnostic-reference-standards/PIFs/OncoSpan-cfDNA
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Bio-Rad introduces new antibodies for in vitro research, commercial applications
, /in Product News /by 3wmediaBio-Rad Laboratories, a specialist in life science research and clinical diagnostic products, has extended its range of recombinant monoclonal anti-idiotypic antibodies with the introduction of antibodies that are specific for ipilimumab (Yervoy) and the ipilimumab/CTLA-4 drug-target complex. These highly specific and high-affinity antibodies are suitable for bioanalytical and patient drug level monitoring assays for the immune checkpoint inhibitor: ipilimumab.
Bio-Rad also announced the launch of a range of anti-certolizumab pegol inhibitory antibodies to support the development of assays for therapeutic drug monitoring of tumor necrosis factor (TNF) alpha inhibitors.
Ipilimumab activates the immune system by inhibiting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a protein receptor that hinders the destruction of cancerous cells, to treat cancers such as melanoma. The four anti-ipilimumab antibodies inhibit the binding of the drug to its target, CTLA-4, and therefore detect free drug. These antibodies are suitable for developing pharmacokinetic (PK) bridging ELISAs and being used as a surrogate positive control (or reference standard) for anti-drug antibody assays. The drug-target complex binder specifically recognizes the ipilimumab/CTLA-4 complex and can be used as the detection antibody in a PK antigen capture assay as an alternative format to the bridging ELISA.
The recombinant monoclonal anti-idiotypic antibodies are generated using the Human Combinatorial Antibody Library (HuCAL®) and CysDisplay®, a proprietary method of phage display with guided selection methods to obtain highly targeted reagents. The recombinant production method also ensures a consistent and secure supply.
The anti-ipilimumab antibodies are approved for in vitro research and for commercial applications of in vitro testing services that support preclinical and clinical drug and biosimilar development and patient monitoring.
Anti-certolizumab pegol inhibitory antibodies
The range of recombinant monoclonal anti-idiotypic antibodies comprises three antibodies that are highly specific for the monoclonal antibody Fab fragment certolizumab pegol (Cimzia) and inhibit the binding of this drug to its target: TNF alpha. The antibodies are fully human in full length IgG format and can be used as a surrogate positive control or calibration standard for an ADA assay to measure levels of patient anti-drug antibodies.
TNF alpha inhibitors are used to treat a wide range of inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and psoriasis. The levels of serum drug and ADA concentrations are monitored in patients receiving TNF alpha antagonists to help guide clinical decision making, optimize treatment, improve outcomes, and reduce healthcare costs.
The anti-certolizumab pegol antibodies are approved for in vitro research and for commercial applications of in vitro testing services that support preclinical and clinical drug and biosimilar development and patient monitoring.
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Better Prep!
, /in Product News /by 3wmediaProvides high efficiency, saves space and enables multi-sample processing /
Customer- and application-specific solution /
Time-saving by simplified, fast operation
Shimadzu, one of the world leaders in analytical instrumentation, has announced the release of its new Nexera Prep Series Preparative Purification Liquid Chromatograph (LC). “Preparative HPLC” is a process in which specific substances are separated and purified from samples. The new Nexera Prep Series provides better prep processes for extraction of functional and impurity components, as well as purification of target compounds in the pharmaceutical, chemical and food industries. This product dramatically improves productivity via flexible scalability and an efficient, user friendly preparative workflow.
Customer- and application-specific solution
The Nexera Prep Series consists of multiple related products with the LC units as the core. Users select a pump, autosampler and detector to build a system according to the purpose of the preparative work. Systems can be configured using related products such as the LH-40 Liquid Handler, FRC-40 Fraction Collector, Shim-pack Scepter LC Column for Analysis and Preparative Work, and Column Hub.
Preparative purification is generally performed following a multi-step workflow, which requires experience and time:
of purified sample or injection volume required
In addition to these steps, in some cases salts need to be removed or solvent needs to be evaporated after purification, requiring additional time and effort.
Time-saving by simplified, fast operation
The Nexera Prep Series reduces the time spent on examining conditions using the software’s fractionation simulation function. It also enables simplified, fast operation in transition from analytical to preparative scale, with a column portfolio that covers a wide range of sizes. Furthermore, Shimadzu’s unique UFPLC (Ultra Fast Preparative and Purification LC) high-purity purification system reduces the time required for powderization via the elution of desalted target components with an organic solvent. This product satisfies a number of user demands, such as efficient desalting and powderization, multi-sample and multi-fraction analysis, effective separation at low cost and the ability to check the purity.
Specifically, the product can be used for the following purposes:
The Nexera Prep Purification LC System provides new features to simplify the preparative workflow:
With the fractionation simulation function of the LabSolutions analysis software and the Shim-pack Scepter LC column for analytical and preparative HPLC, which offers excellent scalability, the product reduces the time required for investigating preparative work conditions. The LH-40 Liquid Handler can be used both, as a fraction collector and as an autosampler for large-volume injection with liquid surface detection function (option). It also enables seamless purity checks through re-injection (option) of collected sample after fractionation. Additional features including a sample rescue protocol to collect the sample from the system if an error occurs after an injection, a function to automatically extract the target peaks only, and high-purity preparative purification using detector signals from up to four channels, enable more efficient operation.
Samples must be in a state of concentrated solution or dry powder to analyze their structure or to store them. When a solution contains water, it takes time to dry and concentrate it. When a salt such as trifluoroacetate has been added, it remains in the crystal of the compound, lowering the purity and negatively influencing pharmacokinetic studies and other tests. Shimadzu’s unique, automated UFPLC purification system introduces fractions containing the target compound, separated in a preparative column, into a trap column. Salt and water are then washed off and elution is induced with an organic solvent. This reduces the time required for drying, providing compounds with a high level of purity.
Both the LH-40 Liquid Handler and FRC-40 Fraction Collector are designed to save installation space, requiring only half the space of other vendors’ products. They support containers of a form and size suitable for the recovered quantity. Up to six units can be connected, so up to 3240 10 mm diameter test tubes can be placed. Using the new Column Hub, up to six columns and four flow-line switching valves can be installed, enabling the compact configuration of various systems.
Web summary
Shimadzu has announced the release of its new Nexera Prep Series Preparative Purification Liquid Chromatograph (LC). It provides better prep processes for extraction of target compounds and impurities during drug discovery in the pharmaceutical industry and purification of functional components in the chemical and food industries. This product improves productivity dramatically via efficient preparative workflows using LC or LC-MS methodology.
Web link: www.shimadzu.eu/nexera-prep
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