C044 Biosystems ace

Angiotensin converting enzyme reagent

In the renin-angiotensin system, the Angiotensin Converting Enzyme (ACE) catalyses the conversion of Angiotensin I to Angiotensin II which is found in the lungs and in vascular endothelium and increases blood pressure by vasoconstriction and salt and water retention. It also degrades bradykinin, decreasing its vasodilator function. The measurement of ACE levels in serum is widely used to aid in the differential diagnosis of clinically active pulmonary sarcoidosis and monitoring its treatment with corticosteroids. It is also used for monitoring ACE inhibitors therapy in other disorders such as hypertension, heart failure and diabetic neuropathy. This new ACE reagent measures its concentration in serum or plasma using a spectrophotometric kinetic method with FAPGG substrate, which is the preferred method for the determination of this marker.

Supplier: BioSystems

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