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1882

Biomarker with remarkable specificity to rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disorder that occurs when the immune system mistakenly attacks the body’s tissues. Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of the joints, causing painful swelling that can eventually result in bone erosion and joint deformity.Most RA patients are positive for anticitrullinated protein antibodies (ACPA), and […]

1883

New Clues about the Blood-Clotting Ability of Leeches

Leeches are blood-feeding organisms that have a suite of anticoagulant compounds they secrete from their salivary glands that prevent blood clotting. This allows them to maximize feeding time and blood volume. Leeches are still used in modern medicine, and knowledge about their anticoagulants is important in many ways, from rodent control to understanding host-parasite relationships. […]

1884

Researchers establish global microbial signatures for colorectal cancer

Patients with colorectal cancer have the same consistent changes in the gut bacteria across continents, cultures, and diets — a team of international researchers, from University of Copenhagen among others, find in a new study. The hope is the results in the future can be used to develop a new method of diagnosing colorectal cancer. […]

1886

Insight into blood signatures of inflammation

A new study from BUSM and BUSPH identifies a pattern of inflammation associated with cardio-metabolic risks among participants in the Black Women’s Health Study, as well as two independent groups of vulnerable women. These findings could help underserved patients benefit from precision medicine and personalized profiles of disease risk. According to the researchers, body mass […]

1887

New technology for diagnosis of Huntington’s disease could give results in days instead of weeks

The world’s first genetic test for Huntington’s disease using nanopore-based DNA sequencing technology is now available at Guy’s and St Thomas’ NHS Foundation Trust. The test could drastically cut the waiting time for the most complicated cases of Huntington’s disease and has huge potential for other genetic disorders in the future. The breakthrough was achieved […]

1888

How-cells-repurpose-their-garbage-disposal-system-to-promote-inflammation

G-protein-coupled receptors (GPCRs) are everywhere in our bodies. They are embedded in our cell membranes, where they act as signal transducers, allowing cells to respond to their external environments. GPCRs play a crucial role in most biological functions, including heart rate, blood pressure, vision, smell, taste and allergic responses. GPCR malfunction can lead to a […]

1889

Revealed: 35 kidney genes linked to chronic kidney disease risk

An international study led by University of Manchester scientists has discovered the identity of genes that predispose people to chronic kidney disease.The discovery is a major advance in understanding the significantly under-diagnosed disorder which, if left undetected, can lead to failing kidneys that need dialysis or kidney transplantation.The discovery of 35 kidney genes is an […]

1890

International team of scientists detect cause of rare pediatric brain disorder

Mathilde came into the world with chubby cheeks and a full head of auburn hair. But she was a very sick baby, and was immediately transferred on January 19, 2013 to the Neonatal Intensive Care Unit at the Montreal Children’s Hospital of the McGill University Health Centre (MCH-MUHC). By the time she arrived, she was […]